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Imaging tumor perfusion, oxidative metabolism using dynamic ace pet in patients with head and neck cancer during radiotherapy

A technology for head and neck cancer and tumors, applied in the field of positron emission tomography tracers, can solve problems such as lack of knowledge

Inactive Publication Date: 2012-05-16
GE HEALTHCARE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] However, current studies on ACE-PET and 18 Insufficient knowledge of F-acetate-PET

Method used

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  • Imaging tumor perfusion, oxidative metabolism using dynamic ace pet in patients with head and neck cancer during radiotherapy
  • Imaging tumor perfusion, oxidative metabolism using dynamic ace pet in patients with head and neck cancer during radiotherapy
  • Imaging tumor perfusion, oxidative metabolism using dynamic ace pet in patients with head and neck cancer during radiotherapy

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Embodiment

[0046] The invention is further described in the following examples, which are not intended to limit the scope of the invention in any way.

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Abstract

The present invention provides methods of using optimal PET tracers for diagnosing head and neck cancer. Non-invasive methods for assessing tumor perfusion and oxidative metabolism for in vivo imaging with PET tracers that are suitable for uses in radiation therapy (RT) in head and neck cancer and evaluation of salivary gland function are provided. A pharmaceutical comprising the PET tracer and a kit for the preparation of the pharmaceutical are provided as well.

Description

field of invention [0001] The present invention relates to the development of positron emission tomography (PET) tracers that can be used for radiotherapy imaging of head and neck cancer. In particular, the present invention relates to the use of in vivo imaging of PET tracers suitable for radiation therapy (RT) of head and neck cancer and evaluation of salivary gland function for the evaluation of tumor perfusion and oxidative metabolism in a non-invasive method. The present invention also provides a medicine comprising the compound and a kit for preparing the medicine. Background of the invention [0002] Tracers labeled with short-lived positron-emitting radionuclides (eg, 18F and 11C) are the positron-emitting radionuclides of choice for many receptor imaging studies. Therefore, radiolabeled ligands have great clinical potential due to their utility in positron emission tomography (PET) for the quantitative detection and characterization of a variety of diseases. [00...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K51/04
CPCA61K51/0402
Inventor J·索伦森S·约翰松A·孙
Owner GE HEALTHCARE LTD
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