Pericarpium citri reticulatae and lemon extract and application of pericarpium citri reticulatae and lemon extract in preparation of medicine for treating salivary gland diseases

Abstract

The pericarpium citri reticulatae and lemon extract is prepared by the following steps: mixing pericarpium citri reticulatae and lemon, adding glycerol until the mixture is completely soaked, extracting, and filtering out the pericarpium citri reticulatae and lemon to obtain a pericarpium citri reticulatae and lemon extracting solution after the extraction is completed. The mass ratio of the dried orange peel to the lemon is (1: 2)-(1: 3). The pericarpium citri reticulatae and lemon extract is applied to preparation of medicines for treating salivary gland dysfunction diseases. According to the technical scheme, clinical research and improvement strategies for maintaining oral thirst of dialysis patients (MHD) are concerned for a long time, according to the traditional Chinese medicine theory that yin is changed from sour to sweet, the oral lubricant prepared from edible-grade dried tangerine or orange peel and lemon in combination with glycerin is adopted, the curative effect on the thirst symptom of the MHD patients is discussed, and the oral lubricant has a good application prospect. It is found that the pericarpium citri reticulatae and lemon glycerin extracting agent can achieve a good curative effect on oral dryness of MHD patients, effectively reduce the weight increment of the patients in the dialysis period, increase salivary gland secretion, improve the subjective feeling of thirst of the patients and improve the life happiness index, and can be clinically applied and popularized.

Description

technical field [0001] The invention relates to an extract of tangerine peel and lemon, and the application of the extract to preparation and treatment of salivary gland dysfunction diseases, belonging to the technical field of pharmacy. Background technique [0002] There are currently more than 1.5 million patients with end-stage renal disease (ESRD) in China, and 120,000 to 150,000 new patients are added every year, which means that the base of ESRD patients in my country is large and growing rapidly. The main treatment measures for ESRD are hemodialysis (HD), peritoneal dialysis (PD) and kidney transplantation (KT). HD has high safety and efficacy and has become a commonly used treatment plan in my country. Dry mouth is one of the common complications of hemodialysis patients. It is mainly manifested as oral thirst, which is difficult to relieve by drinking water. In severe cases, chapped tongue coating may appear. Domestic epidemiological studies have found that 73.8% ...

AI Technical Summary

Problems solved by technology

Domestic epidemiology studies have found that 73.8% to 92.1% of hemodialysis patients have xerostomia, and persistent xerostomia will cause patients to drink too much water, resulting in excessive and rapid weight gain between dialysis periods, increased effective circulating blood volume, pulmonary edema, and acute heart failure. The incidence of complications such as failure increases, which seriously threatens the life and health of patients

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