28 results about "ORAL DRYNESS" patented technology

The invention discloses an ultraviolet rhinitis therapeutic apparatus, and belongs to the technical field of rhinitis therapeutic apparatuses, the ultraviolet rhinitis therapeutic apparatus comprises a therapeutic apparatus main body, an adjusting assembly is assembled in the therapeutic apparatus main body, and a phototherapy assembly is assembled at the end of the adjusting assembly; by arranging the adjusting assembly and the phototherapy assembly, non-invasive fixation and nasal septum protection are achieved, three areas of the protection sleeve are controlled to bulge through a tough piece to be attached to the inner wall of the nasal cavity in a self-adaptive mode, a traditional nose clip mechanical clamping mode is replaced, and the risk of mucous membrane injury, bleeding or structural deformation caused by direct pressing of the nasal septum is avoided; meanwhile, the movable seat slides along the inner cavity of the tail plug under the driving of the screw rod, the inclined end of the movable seat pushes the inclined surface seat to enable the flexible sheet to expand outwards, the corresponding area of the protective sleeve is driven to bulge, the nasal cavity shape difference of different patients is adapted, the fixing stability is improved, and the foreign body sensation is reduced; the secondary problems of dry mouth, throat discomfort and the like caused by mouth breathing are avoided, and the treatment comfort is guaranteed.

Liquid formulation including cevimeline hydrochloride and a combination of at least one sweetener and at least one flavoring agent to mask the bitter taste of cevimeline hydrochloride oral solutions. The liquid formulation may be administered to a patient to alleviate dry mouth symptoms associated with xerostomia and Sjogren's syndrome.

This product is a lip piece for nasal breathing during sleep. Traditionally, mouthpieces are worn between the upper and lower teeth inside the mouth, but this lip piece is placed between the upper and lower gums and lips, covering the entire lip, and has a slightly elongated ring shape. It utilizes the principle that even ordinary people can achieve nasal and diaphragmatic breathing by opening their mouths wide like singers. One piece can be fitted to set two sizes, slightly elongated vertically and slightly horizontally. This allows for adjustments to the size of the person's mouth and jaw closure, adjustment of the amount of air, and multi-purpose use such as daytime fitting practice or nighttime sleep use. The material is synthetic resin, and you can choose between a harder (plastic) and a softer (elastomer) version. When this product is worn on the lips, the larynx opens, ensuring an open airway during sleep, allowing for smooth nasal breathing, and preventing snoring and sleep apnea. Furthermore, since it prevents mouth breathing even when the mouth is open, it can prevent various problems associated with mouth breathing. It can be used by a wide range of ages, from infants with underdeveloped lower jaws who grind their teeth, to adults with teeth clenching, dry mouth, temporomandibular joint disorders, and elderly people at risk of aspiration, and is harmless. Once the discomfort of wearing it is overcome, it promotes restful sleep with light and safe nasal breathing. Other benefits include improved blood flow to the muscles around the mouth, while at the same time creating a slight tension in the lips, which is good for blood flow to the brain. The lips relax and the salivary glands work, so saliva is produced, but the structure prevents saliva from spilling out of the mouth. The base of the tongue is more easily moved forward, so the epiglottis (the lid for swallowing) moves. It is also expected to help prevent silent aspiration pneumonia.

The present invention relates to a hydrating patch. The hydrating patch (100) comprises a biodegradable and biocompatible absorbent inset (106). The absorbent inset (106) absorbs and retains a liquid, and discharge an absorbed liquid when pressed. The hydrating patch (100) also comprises a biocompatible matrix (102) which supports the absorbent inset (106). The biocompatible matrix (102) is flexible. To attach the biocompatible matrix (102) to a biological membrane, a sticking layer (110) is attached to the biocompatible matrix (102). The hydrating patch (100) can be attached in the oral cavity to alleviate dryness in a person having a dry mouth condition.

The invention discloses artificial saliva and a preparation method of artificial saliva hydrogel. The artificial saliva is prepared from the following raw materials in parts by mass: 0.5 to 1 g of KCl, 0.2 to 0.4 g of K2HPO4, 0.2 to 0.8 g of NaCl, 0.2 to 0.4 g of KH2P O4, 10.04 to 20.8 g of CaCl2, 1.5 to 3 g of Nacaboxymethlecellulose, 60 to 120 mg of brown moss alcohol, 495 to 1000 ml of natural coconut juice and 5 to 10 ml of herba sarcandrae extract. By selecting the glabrous sarcandra herb extract, anti-inflammatory and anti-tumor treatment is realized, so that the traditional Chinese medicine composition has a remarkable effect on dry mouth caused by radiotherapy; through the form of a gel bead preparation, the beverage is more portable and unique in taste. The gel beads serve as one of oral local administration preparations, and after the gel beads are exploded, drugs can target small glands which are located below oral mucosa and secrete saliva, and the rapid drug effect is achieved. Direct local administration to the oral mucosa may provide rapid drug action, activate small salivary glands within the buccal mucosa, while avoiding systemic drug exposure and off-target effect.

Kit and method for treating patients with dry mouth syndrome. The kit includes a dental mouthpiece with one or more near-infrared light sources. Once placed in the oral cavity, it directs the light toward the selected target tissue (salivary glands, submandibular glands, or both) for the treatment of patients with dry mouth syndrome. The kit and method can be used to treat Sjögren's syndrome, patients taking multiple medications, diabetic patients, or patients with a reduced number of salivary glands, resulting in a marked, temporary, or permanent decrease in saliva production.

A mouthpiece device and method for helping human users with congested sinuses breathe freely through their mouths while sleeping while minimizing the risks of dry mouth and drooling. The device fits between the user's jaws and is configured to apply a gentle jaw and lip opening pressure sufficient to at least partially open a sleeping user's jaw and lips while the jaw and lip muscles are relaxed. At the same time, the device is configured to so that when the user, while still sleeping, activates their jaw or lip muscles to swallow, this action overcomes the gentle opening force, allowing the user to easily swallow without conscious effort. Methods of configuring the device shape and opening forces are also taught. These include using implanted sensors, processors, and actuators configured to optimize the opening forces according to user physiology; and / or wireless connection to external sensing and control devices.

This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a traditional Chinese medicine composition for treating dry mouth in Sjögren's syndrome and its preparation method. The traditional Chinese medicine composition includes the following raw materials in parts by weight: 10g Rehmannia glutinosa, 9g Scrophularia ningpoensis, 10g Ophiopogon japonicus, 10g Fagopyrum dibotrys, 10g Phragmites communis, 6g Amomum villosum, and 3g Bletilla striata. Depending on clinical diagnosis, other herbs such as Cornus officinalis, Trichosanthes kirilowii, Lophatherum gracile, Paeonia suffruticosa, and Poria cocos may be selectively added. The preparation method includes two decoctions, filtration, and combining the filtrates. It is derived from the Kidney-Nourishing, Heat-Clearing, and Yin-Nourishing Decoction, retaining the core of the Fluid-Increasing Decoction, and adding three lung / stomach meridian-invigorating herbs: Fagopyrum dibotrys, Phragmites communis, and Bletilla striata. The core treatment principle is to nourish yin and generate fluids, clear heat and remove blood stasis, promote tissue regeneration and wound healing, and harmonize the spleen and stomach. Clinical observation shows that it can significantly reduce the VAS score for dry mouth in patients with Sjögren's syndrome, increase static salivary flow rate, and promote the recovery of oral mucosal ulcers and angular cheilitis. It has good safety and can be taken orally for overall conditioning or used as a mouthwash to directly target the affected area.

The utility model discloses an oral cavity support for radiotherapy positioning in the department of radiotherapy, which relates to the field of medical instruments and comprises an oral cavity support. The tongue depressor comprises an upper arch groove, a lower arch groove is formed in one end of the upper arch groove, the upper arch groove and the lower arch groove are connected through two rotating shafts, reset springs are symmetrically installed at the bottom of the lower arch groove, and a tongue depressor is installed at the bottoms of the reset springs which are symmetrically arranged. The two fixing assemblies are symmetrically arranged, and the fixing assemblies are installed between the upper arch groove and the lower arch groove; the clamping assembly is mounted in the lower arch groove; the oral cavity support for radiotherapy positioning in the radiotherapy department is convenient, a patient does not need to see a doctor in the stomatology department, and the oral cavity support can be operated and worn by himself / herself. The fixing precision and repeatability of the upper jaw, the lower jaw and the tongue are improved, so that adverse reactions such as oral mucositis, gustatory disorder and xerostomia are reduced; the fixing precision is improved while individualization is achieved through the oral cavity support, occlusion and wearing of a patient are facilitated, the manufacturing method is simple, and clinical quantitative popularization is facilitated.

To provide a composition capable of exhibiting new effects of bay laurel (LaurusnobilisL.).SOLUTION: The composition contains an extract of bay laurel (LaurusnobilisL.), has an antibacterial action against Tannerellaforsythensis and Streptococcusmutans, suppresses gingival inflammation, spontaneous bleeding of gums and plaque accumulation, improves dryness in the oral cavity and saliva pH, suppresses halitosis and improves constipation. Specifically, the present invention relates to an antibacterial agent against periodontal disease-related bacteria and dental caries-related bacteria, a composition for preventing or treating periodontal disease, a composition for preventing or treating dental caries, a composition for improving gingiva, a composition for improving gums, a composition for suppressing plaque (dental plaque) accumulation, a composition for improving xerostomia, a composition for improving saliva, a composition for suppressing halitosis, and a composition for improving constipation, each of which contains a bay laurel (LaurusnobilisL.) extract as an active ingredient. By containing the bay laurel (LaurusnobilisL.) extract, it is possible to suppress Tannerellaforsythensis and Streptococcusmutans which are periodontal disease-related bacteria, suppress gingival inflammation, spontaneous bleeding of gums, and plaque accumulation, improve dryness in the oral cavity and saliva pH, suppress halitosis, and improve constipation.SELECTED DRAWING: None

The application provides a traditional Chinese medicine composition for treating or improving Sjogren's syndrome, and belongs to the technical field of traditional Chinese medicine pharmacy.The traditional Chinese medicine composition takes asparagus, lily and mulberry as monarch drugs, takes honeysuckle, semen astragali, rush and radix codonopsis as minister drugs, takes turmeric and atractylodes as auxiliary drugs, and takes licorice as a guide drug, and the drugs are combined to have the effects of nourishing yin and moistening dryness, clearing heat and dredging collaterals, tonifying qi and invigorating the spleen, and promoting blood circulation and improving eyesight.The traditional Chinese medicine composition can significantly reduce the water consumption of NOD mice, increase the saliva amount of NOD mice, significantly down-regulate the levels of inflammatory factors TNF-alpha, IL-17 and IL-1beta in the serum of NOD mice, improve the gland structure and lymphocyte infiltration in the submandibular gland tissue of NOD mice, and reduce the submandibular gland injury.In addition, the traditional Chinese medicine composition can significantly reduce the ESSDAI and ESSPRI scores of Sjogren's syndrome patients, improve the clinical symptoms such as dry mouth, dry eyes and salivary gland swelling of the patients, has a high total effective rate in clinical treatment, and can be further developed and researched as a drug for treating Sjogren's syndrome.

The invention provides a dry mouth nursing device for anesthetized patients, the dry mouth nursing device for anesthetized patients comprises an atomization module, a shield, a side wetting module and a bottom wetting module, the atomization module is connected with the side wetting module and the bottom wetting module through an air pipe, and the air pipe penetrates through the shield; the two side face wetting modules are symmetrically arranged on the two sides of the bottom wetting module, an atomization unit and a detection unit are arranged in the atomization module, and a control unit is arranged in the protective cover. According to the invention, sampling detection is carried out through the detection sensor, the humidity in the oral cavity is determined, automatic wetting control is carried out according to the humidity, the oral cavity is wetted timely and effectively without assistance of other people, and the nursing cost and labor are reduced.

Liquid formulations including cevimeline hydrochloride and a combination of at least one sweetener and at least one flavoring agent to mask the bitter taste of the cevimeline hydrochloride when formulated for oral administration. A taste masking composition that masks the bitter taste of cevimeline hydrochloride when formulated for oral administration, wherein the taste masking composition includes two or more sweeteners and two or more flavoring agents. Liquid formulations including cevimeline hydrochloride and the taste masking composition. The liquid formulations including cevimeline hydrochloride may be administered to a patient to alleviate dry mouth symptoms associated with xerostomia and Sjogren's syndrome.

The invention discloses a saliva flow rate detection strip for auxiliary diagnosis of xerostomia and a detection method thereof. The detection strip comprises strip-shaped filter paper pretreated by fluorescein sodium, the filter paper is packaged in a food-grade plastic shell, one end of the filter paper extends out of the shell to form a 0.5 cm sampling part, and scale marks are arranged on the filter paper. During detection, the sampling part is placed under the tongue for 3 minutes, saliva infiltrates along the filter paper under the capillary action and dissolves the fluorescein sodium for color development, and the flow rate of the unstimulated saliva can be obtained through conversion by reading the infiltration length. The detection strip can effectively distinguish a control person from a sicca syndrome patient, a xerostomia patient and the like. The problems that a traditional method is long in consumed time, poor in experience and inconvenient to operate are solved, and a detection tool which is rapid, objective and standardized and is in seamless butt joint with an existing diagnostic standard is provided.

The invention discloses a method for detecting mouth dryness, which is characterized in that test paper is used for detection, the test paper comprises a plurality of detection layers, and the detection layer on the outer side wraps the other detection layers in sequence, so that the whole body is in a water drop shape; the color developing layer adopts a starch coating, can be subjected to specific biochemical reaction with a specific marker in saliva, is only sensitive to'saliva marker abnormity 'caused by pathology or drugs, and is not interfered by drinking water physiological factors; compared with the traditional humidity measurement principle, the problem of misjudgment of physiological thirst is solved.

The invention discloses an oral gargle as well as a preparation method and application thereof, relates to the technical field of oral care, and solves the problem that an existing product is difficult to safely and effectively relieve a dry mouth symptom for a long time. Comprising a moisturizing film-forming agent, an antibacterial disinfectant, an anti-allergy soothing agent and a flavoring agent, the moisturizing film-forming agent is polyethylene glycol active ester. The antibacterial disinfectant is selected from chlorhexidine, chlorhexidine acetate, benzalkonium chloride and polyhexamethylene biguanidine; the anti-allergy soothing agent is selected from allantoin, tocopherol acetate, tranexamic acid, dipotassium glycyrrhizinate, a calendula extract, a chamomile extract, matricaria recutita / eucalyptus globulus leaf oil, a tea leaf extract, a propolis extract and the like; the flavoring agent is selected from peppermint essence, xylitol, sucralose, saccharin sodium salt and sodium citrate. The mouthwash can be used as a product for preventing or treating xerostomia or oral mucositis, and the mouthwash is packaged in a powder form and forms a product unit together with an auxiliary bottle for dissolving the powder.

Liquid formulations including cevimeline hydrochloride and a combination of at least one sweetener and at least one flavoring agent to mask the bitter taste of the cevimeline hydrochloride when formulated for oral administration. A taste masking composition that masks the bitter taste of cevimeline hydrochloride when formulated for oral administration, wherein the taste masking composition includes two or more sweeteners and two or more flavoring agents. Liquid formulations including cevimeline hydrochloride and the taste masking composition. The liquid formulations including cevimeline hydrochloride may be administered to a patient to alleviate dry mouth symptoms associated with xerostomia and Sjogren's syndrome.

The invention relates to the field of medical care equipment, in particular to a device convenient for nursing dry mouth of an anesthetized patient, which comprises a spraying mechanism, a mouth-holding cover is detachably connected to the spraying mechanism, a plurality of air holes are formed in the outer side of the mouth-holding cover in an array manner, and the spraying mechanism is used for conveying water mist to the air holes. A plurality of recovery ports are formed in the side, close to the throat, of the buccal cover in the circumferential direction and communicate with a negative pressure mechanism, and the negative pressure mechanism is used for generating negative pressure with preset strength at the recovery ports. According to the invention, excessive liquid and saliva generated in the oral cavity can be instantly and actively sucked while proper moisture is provided for the oral mucosa, so that the risk that the liquid is accumulated in the pharynx is reduced, and the nursing safety and comfort are improved.

The current disclosure relates to the preparation of topical oral solutions of simpinicline ((R)-5-((E)-2-pyrrolidin-3-ylvinyl)pyrimidine) and pharmaceutically acceptable salts thereof and their use in treating dry mouth.

The invention relates to an external traditional Chinese medicine composition for treating oral ulcer and a preparation method thereof. The composition comprises the following components in parts by weight: 1-60 parts of coptis chinensis, 1-60 parts of bombyx batryticatus, 1-30 parts of gallnut, 1-60 parts of raw liquorice and the balance of auxiliary materials required by common solid or liquid preparations. The traditional Chinese medicine composition can be prepared into solid preparations such as powder, cream, paste and oral patches. The traditional Chinese medicine composition can be prepared into liquid preparations such as linimentum, paste, film, liniment, spray and decocted extract. The traditional Chinese medicine composition is prepared under the guidance of traditional Chinese medicine theory, has the effects of astringing dampness and sores, removing toxicity for detumescence, dispelling wind and removing stasis, clearing away heart-fire and purging spleen, has the pharmacological effects of inhibiting bacteria and diminishing inflammation and promoting ulcer surface healing, and is externally used for treating oral ulcer. The symptoms and characteristics of the treated crowd include local scorching heat and pain of aphtha, obvious red and swollen wounds, yellow secretions on the surface, dry mouth and halitosis, vexation and insomnia, dry stool and dark urine, red tongue tip, yellow coating and new or repeated attack of dental ulcer.

The invention relates to the technical field of daily chemical products and oral care, and discloses a preparation method of Chinese herbal medicine toothpaste and application of the Chinese herbal medicine toothpaste in oral disease treatment, and the method prepares paste with double functions of physical shielding and chemical bacteriostasis by constructing a pH steady-state system and adding active components step by step. In the preparation, the broad-spectrum functional active extract is subjected to heat reflux extraction, the bioadhesive repair extract is subjected to low-temperature extraction and alcohol precipitation, and the bioadhesive repair extract is added after being subjected to low-temperature and low-shear conditions so as to retain the polysaccharide conformation. The obtained toothpaste contains honeysuckle, scutellaria baicalensis, bletilla striata and other traditional Chinese medicine components, can stably maintain the drug effect, and forms a biological adhesion film on the mucous membrane surface. The toothpaste can effectively improve oral ulcer, periodontitis, gingival bleeding and xerostomia complicated by diabetes mellitus, solves the problems of low drug retention rate and poor stability of existing products in the oral environment of diabetes mellitus, and realizes treatment of both symptoms and root causes.

This invention discloses the application of geraniol in the preparation of a drug for treating Sjögren's syndrome. In vivo experiments using a NOD mouse model of Sjögren's syndrome demonstrated that geraniol treatment significantly improved salivary secretion disorders and reduced abnormally high water intake in the mice; significantly reduced lymphocyte infiltration in salivary gland tissue, improved glandular pathological damage, downregulated the levels of characteristic autoantibodies (Anti-SSA / Ro and Anti-SSB / La) in serum, upregulated the expression levels of AQP5 and AR, and reduced organ indices in salivary glands, spleen, and thymus tissue, comprehensively improving dry mouth symptoms in mice. In vitro experiments also showed that geraniol treatment upregulated the expression levels of AQP5 and AR. Therefore, this invention provides the application of geraniol in the preparation of a drug for treating Sjögren's syndrome, which has the advantages of significant efficacy and addressing both the symptoms and root cause, and possesses good clinical application prospects.

The utility model discloses an oral cavity fixing device for head and neck tumor radiotherapy, and relates to the technical field of medical instruments. Comprising an upper tooth socket and a lower tooth socket, and a tongue depressor is arranged on the lower tooth socket; the front ends of the upper tooth socket and the lower tooth socket are rotationally connected; a sliding block is arranged between the upper tooth socket and the lower tooth socket in a sliding manner; a clamping mechanism for driving the sliding block to move is arranged on the lower tooth socket in a sliding manner; a plurality of clamping grooves for limiting the clamping mechanism are formed in the lower tooth socket; the oral cavity fixing device is also provided with a mouth moistening mechanism; a clamping groove, a sliding block and a clamping mechanism are matched, the opening angle of the upper tooth socket and the lower tooth socket can be adjusted and fixed, and the consistency of the opening angle of the oral cavity of the same patient during radiotherapy each time is ensured; the mouth moistening mechanism achieves autonomous control of the patient, relieves the symptom of dry mouth, and avoids the situation that the patient coughs autonomously when dry mouth is hard to tolerate, and consequently the positioning accuracy is affected. According to the utility model, the fixation of the oral cavity during radiotherapy of the head and neck is effectively ensured, the accuracy of radiotherapy is improved, and the smooth proceeding of radiotherapy is ensured.

The present invention relates to a hydrating patch. The hydrating patch (100) comprises a biodegradable and biocompatible absorbent inset (106). The absorbent inset (106) absorbs and retains a liquid, and discharge an absorbed liquid when pressed. The hydrating patch (100) also comprises a biocompatible matrix (102) which supports the absorbent inset (106). The biocompatible matrix (102) is flexible. To attach the biocompatible matrix (102) to a biological membrane, a sticking layer (110) is attached to the biocompatible matrix (102). The hydrating patch (100) can be attached in the oral cavity to alleviate dryness in a person having a dry mouth condition.

An oral care composition for use in the treatment of dry mouth comprising at least one thickening agent in an amount of 0.1 to 15 wt% based on the weight of the oral care composition, a pH buffering agent in an amount of 0.5 to 2 wt% based on the weight of the oral care composition, at least two humectants in an amount of 15 to 30 wt% based on the weight of the oral care composition, water in an amount of 66.5 to 83.6 wt% based on the weight of the oral care composition, under the form of a gel.

Articles that include from 20 wt-% to 45 wt-% of one or more plant based oils based on the total weight of the article; from 50 wt-% to 70 wt-% of one or more polymer film formers based on the total weight of the article; and from 5 wt-% to 15 wt-% of one or more humectants based on the total weight of the article. Further articles comprises this combination of oil, film former and humectant as a first layer adjacent to which a second layer comprises a mucoadhesive polymer. The articles may be used to prevent formation or maintenance of biofilm in an oral tissue, affect hydration loss in an oral tissue, affect lubricity or lubriciousness in an oral tissue or treat xerostomia or dry mouth. Preferred polymer film formers include pullulan, xanthan gum, HP guar, ethyl cellulose and carrageenan.

The application discloses application of dihydroeugenol in preparation of a medicine for treating Sjogren's syndrome. Through in-vivo experiments of a Sjogren's syndrome model of NOD mice, it is proved that after dihydroeugenol treatment, the saliva secretion disorder of the Sjogren's syndrome model mice can be significantly improved, the abnormally increased water consumption can be reduced, the lymphocyte infiltration of the salivary gland tissue can be significantly reduced, the pathological damage of the gland can be improved, the level of the characteristic autoantibody (Anti-SSA / Ro and Anti-SSB / La) in serum can be lowered, the expression level of AQP5 and AR can be raised, the organ index of the salivary gland, spleen and thymus tissue can be reduced, and the dry mouth symptom of the mice is comprehensively improved. In-vitro experiments also show that after dihydroeugenol treatment, the expression level of AQP5 and AR can be raised. Therefore, the application of dihydroeugenol in preparation of the medicine for treating Sjogren's syndrome has the advantages of significant curative effect, treating both the symptoms and the root cause, and good clinical application prospect.