48 results about "ORAL DRYNESS" patented technology

The invention discloses a traditional Chinese medicine compound composition with an effect of preventing and treating radioactive injury as well as a preparation method and application thereof. The traditional Chinese medicine compound composition is prepared from 5-15 parts of American ginseng, 3-6 parts of sea-buckthorn and 10-30 parts of rhizoma polygonati. The composition is proportioned and optimized according to the theory of treatment based on syndrome differentiation, and the medicines are combined to achieve the effects of tonifying qi, activating blood and nourishing yin. Clinical experiment results show that the traditional Chinese medicine compound composition provided by the invention has a remarkable effect of preventing and treating radioactive injury, particularly has a remarkable curative effect in the aspects of improving oral mucositis, dry mouth, weakness, sleep disorder and the like after radiotherapy, and is safe in clinical medication.

The invention discloses an ultraviolet rhinitis therapeutic apparatus, and belongs to the technical field of rhinitis therapeutic apparatuses, the ultraviolet rhinitis therapeutic apparatus comprises a therapeutic apparatus main body, an adjusting assembly is assembled in the therapeutic apparatus main body, and a phototherapy assembly is assembled at the end of the adjusting assembly; by arranging the adjusting assembly and the phototherapy assembly, non-invasive fixation and nasal septum protection are achieved, three areas of the protection sleeve are controlled to bulge through a tough piece to be attached to the inner wall of the nasal cavity in a self-adaptive mode, a traditional nose clip mechanical clamping mode is replaced, and the risk of mucous membrane injury, bleeding or structural deformation caused by direct pressing of the nasal septum is avoided; meanwhile, the movable seat slides along the inner cavity of the tail plug under the driving of the screw rod, the inclined end of the movable seat pushes the inclined surface seat to enable the flexible sheet to expand outwards, the corresponding area of the protective sleeve is driven to bulge, the nasal cavity shape difference of different patients is adapted, the fixing stability is improved, and the foreign body sensation is reduced; the secondary problems of dry mouth, throat discomfort and the like caused by mouth breathing are avoided, and the treatment comfort is guaranteed.

Liquid formulation including cevimeline hydrochloride and a combination of at least one sweetener and at least one flavoring agent to mask the bitter taste of cevimeline hydrochloride oral solutions. The liquid formulation may be administered to a patient to alleviate dry mouth symptoms associated with xerostomia and Sjogren's syndrome.

The utility model belongs to the technical field of dental prosthesis design, and particularly discloses a hollow base liquid storage type removable denture which comprises a base and artificial teeth arranged on the base, the base is a hollow base with a liquid storage cavity, the hollow base is provided with a plurality of overflow discharge channels communicated with the liquid storage cavity, and the diameter of the outlet end of each overflow discharge channel is 0.3-1mm; a plurality of tissue surface adsorption structures are arranged on the tissue surface part of the base plate. The removable denture disclosed by the utility model can automatically and slowly release artificial saliva, so that the dry feeling of an oral cavity is reduced; due to the design of the tissue surface adsorption structure on the tissue surface, the contact area between the base plate and the oral cavity tissue is increased, so that the adsorption force is improved.

The invention discloses a treatment composition to treat nasal or oral dryness and allergy symptoms, and a method for using the same. Certain compositions include xylitol, at least two wetting agents, an aqueous carrier, and other active ingredients, such as a potassium salt, a sodium salt, and a preservative. The composition may be configured as a nasal or oral spray, and oral rinse, or a nasal gel.

The invention provides a yin-nourishing sore-throat-relieving drink composition. The composition is prepared from the following raw materials by weight: 400g of pears, 100g of fructus phyllanthi, 150g of herba houttuyniae, 80g of Chinese dates, 30g of gordon euryale seeds, 15g of honey-fried licorice roots and 15g of Chinese wolfberry fruits. The composition synergistically exerts the effects of relieving cough and reducing sputum, nourishing yin and moistening dryness and clearing away heat and toxic materials through scientific compatibility, is suitable for relieving lung dryness cough, swollen sore throat, dry throat and mouth dryness and other symptoms, and is safe and suitable for long-term drinking due to the fact that most of the raw materials are medicinal and edible.

This product is a lip piece for nasal breathing during sleep. Traditionally, mouthpieces are worn between the upper and lower teeth inside the mouth, but this lip piece is placed between the upper and lower gums and lips, covering the entire lip, and has a slightly elongated ring shape. It utilizes the principle that even ordinary people can achieve nasal and diaphragmatic breathing by opening their mouths wide like singers. One piece can be fitted to set two sizes, slightly elongated vertically and slightly horizontally. This allows for adjustments to the size of the person's mouth and jaw closure, adjustment of the amount of air, and multi-purpose use such as daytime fitting practice or nighttime sleep use. The material is synthetic resin, and you can choose between a harder (plastic) and a softer (elastomer) version. When this product is worn on the lips, the larynx opens, ensuring an open airway during sleep, allowing for smooth nasal breathing, and preventing snoring and sleep apnea. Furthermore, since it prevents mouth breathing even when the mouth is open, it can prevent various problems associated with mouth breathing. It can be used by a wide range of ages, from infants with underdeveloped lower jaws who grind their teeth, to adults with teeth clenching, dry mouth, temporomandibular joint disorders, and elderly people at risk of aspiration, and is harmless. Once the discomfort of wearing it is overcome, it promotes restful sleep with light and safe nasal breathing. Other benefits include improved blood flow to the muscles around the mouth, while at the same time creating a slight tension in the lips, which is good for blood flow to the brain. The lips relax and the salivary glands work, so saliva is produced, but the structure prevents saliva from spilling out of the mouth. The base of the tongue is more easily moved forward, so the epiglottis (the lid for swallowing) moves. It is also expected to help prevent silent aspiration pneumonia.

The present invention relates to a hydrating patch. The hydrating patch (100) comprises a biodegradable and biocompatible absorbent inset (106). The absorbent inset (106) absorbs and retains a liquid, and discharge an absorbed liquid when pressed. The hydrating patch (100) also comprises a biocompatible matrix (102) which supports the absorbent inset (106). The biocompatible matrix (102) is flexible. To attach the biocompatible matrix (102) to a biological membrane, a sticking layer (110) is attached to the biocompatible matrix (102). The hydrating patch (100) can be attached in the oral cavity to alleviate dryness in a person having a dry mouth condition.

The invention belongs to the technical field of food functional ingredients and biological materials, and particularly discloses an oral cavity lubrication composition, an additive and a preparation method and application of the oral cavity lubrication composition and the additive. The lubrication enhancer is one or more of sugar alcohol compounds; the interface stabilizer is one or more of mammal-derived mucoproteins. According to the oral cavity lubricating composition, the additive and the preparation method and application of the additive, the preparation process is simple and controllable, the lubricating additive has good biocompatibility, the lubricating effect in the oral cavity is remarkably improved, the oral cavity dryness is relieved, the food oral cavity digestion effect is improved, and the additive is suitable for improving oral cavity dysfunctions such as the xerostomia.

The invention relates to the technical field of ventilation treatment devices, and discloses a device for providing ventilation treatment, which comprises a head-mounted assembly, a nose oxygen supply unit and a fixing unit, the head-mounted assembly comprises a hoop ring and a guide sheet attached to the outer arc surface of the hoop ring; the device effectively solves the problems of facial indentation, skin injury and claustrophobic fear caused by traditional head wearing, and remarkably improves the wearing comfort and long-term use willingness; the firm physiological structure of the teeth is used for anchoring, the problem that a traditional nasal oxygen cannula is prone to displacement and falling off is successfully solved, and the stability when the nasal oxygen cannula is worn is greatly improved; the fixing unit keeps the lip closing state in a physical mode, the air leakage condition of the mouth in noninvasive ventilation is avoided, the effectiveness of treatment is ensured, and the oral cavity is effectively prevented from being dry. According to the device, the modularized and quickly detachable design is adopted, a user is allowed to flexibly assemble the device according to requirements, convenience of daily use is considered, and the stability requirement in a specific scene is met.

A formulation for treating xerostomia and alleviating the symptoms of dry mouth is provided. Formulations comprising a humectant (such as propylene glycol), a chelator (such as EDTA and its salts) and a transport enhancer (such as methylsulfonylmethane (MSM)) are provided.

The invention discloses an application of bead exosome-like nano-vesicles in treatment of Sjogren's syndrome. The bead exosome-like nano-vesicle is prepared through a differential centrifugation method and an ultracentrifugation method, and toxicological evaluation shows that the bead exosome-like nano-vesicle has good safety and can be used for in-vivo and in-vitro treatment. In-vivo experiments prove that the Sjogren's syndrome model mouse treated by the bead exosome-like nano-vesicles has significantly increased salivary secretion and significantly improved dry mouth symptom; in-vitro experiments further show that the nano vesicles can also significantly improve the activity and the water secretion function of salivary gland epithelial cells in the Sjogren's syndrome. The exosome-like nano-vesicles are successfully extracted from bead leaves and are creatively used for treating the Sjogren's syndrome, and a brand new thought and a material source are provided for research and development of medicines for treating the Sjogren's syndrome.

The invention discloses artificial saliva and a preparation method of artificial saliva hydrogel. The artificial saliva is prepared from the following raw materials in parts by mass: 0.5 to 1 g of KCl, 0.2 to 0.4 g of K2HPO4, 0.2 to 0.8 g of NaCl, 0.2 to 0.4 g of KH2P O4, 10.04 to 20.8 g of CaCl2, 1.5 to 3 g of Nacaboxymethlecellulose, 60 to 120 mg of brown moss alcohol, 495 to 1000 ml of natural coconut juice and 5 to 10 ml of herba sarcandrae extract. By selecting the glabrous sarcandra herb extract, anti-inflammatory and anti-tumor treatment is realized, so that the traditional Chinese medicine composition has a remarkable effect on dry mouth caused by radiotherapy; through the form of a gel bead preparation, the beverage is more portable and unique in taste. The gel beads serve as one of oral local administration preparations, and after the gel beads are exploded, drugs can target small glands which are located below oral mucosa and secrete saliva, and the rapid drug effect is achieved. Direct local administration to the oral mucosa may provide rapid drug action, activate small salivary glands within the buccal mucosa, while avoiding systemic drug exposure and off-target effect.

Kit and method for treating patients with dry mouth syndrome. The kit includes a dental mouthpiece with one or more near-infrared light sources. Once placed in the oral cavity, it directs the light toward the selected target tissue (salivary glands, submandibular glands, or both) for the treatment of patients with dry mouth syndrome. The kit and method can be used to treat Sjögren's syndrome, patients taking multiple medications, diabetic patients, or patients with a reduced number of salivary glands, resulting in a marked, temporary, or permanent decrease in saliva production.

The invention aims to provide a device convenient for mouth dryness nursing of an anesthetized patient, and relates to the technical field of medical instruments, a connector is detachably mounted above a liquid storage bottle, a mounting seat is fixedly arranged on the connector, and a moistener, a spreader and a lip moistener are arranged on the mounting seat; during use, the position of the lip plate is adjusted through the telescopic rod, the two arc-shaped grooves in the lip plate clamp the upper lip and the lower lip of a patient, liquid in the liquid storage bottle is conveyed to the lip plate through the liquid pump, and the liquid is sprayed out through the spraying holes to wet the lips; the upper supporting plate and the lower supporting plate of the dilator abut against the upper teeth and the lower teeth of a patient respectively, the motor in the mounting base drives the upper supporting plate to slide to dilate the oral cavity of the patient, the moistener can stretch into the oral cavity conveniently, the tongue pressing frame of the moistener can press the tongue, it is avoided that the tongue is lifted up to affect operation, and the movable handle is rotated to drive the wetting plate to rotate to be opened. And then the liquid is conveyed to the wetting plate through the infusion pump and is sprayed out through the spraying holes of the wetting plate to wet the oral cavity and the tongue.

The invention provides a traditional Chinese medicine composition for relieving dry mouth and thirst and a preparation method thereof. The traditional Chinese medicine composition is prepared from 10-20 parts by weight of poria cocos, 10-20 parts by weight of radix puerariae, 5-15 parts by weight of American ginseng, 10-20 parts by weight of rhizoma polygonati, 5-15 parts by weight of dark plum, 3-10 parts by weight of liquorice and 5-15 parts by weight of mint. The invention also provides a preparation method of the traditional Chinese medicine composition. The traditional Chinese medicine composition provided by the invention can effectively relieve dry mouth and thirst caused by sicca syndrome, diabetes mellitus, hyperthyroidism and sleep apnea, or dry mouth and thirst caused by treatment of chronic heart failure patients taking diuretics.

A mouthpiece device and method for helping human users with congested sinuses breathe freely through their mouths while sleeping while minimizing the risks of dry mouth and drooling. The device fits between the user's jaws and is configured to apply a gentle jaw and lip opening pressure sufficient to at least partially open a sleeping user's jaw and lips while the jaw and lip muscles are relaxed. At the same time, the device is configured to so that when the user, while still sleeping, activates their jaw or lip muscles to swallow, this action overcomes the gentle opening force, allowing the user to easily swallow without conscious effort. Methods of configuring the device shape and opening forces are also taught. These include using implanted sensors, processors, and actuators configured to optimize the opening forces according to user physiology; and / or wireless connection to external sensing and control devices.

This invention belongs to the field of traditional Chinese medicine preparation technology, specifically relating to a traditional Chinese medicine composition for treating dry mouth in Sjögren's syndrome and its preparation method. The traditional Chinese medicine composition includes the following raw materials in parts by weight: 10g Rehmannia glutinosa, 9g Scrophularia ningpoensis, 10g Ophiopogon japonicus, 10g Fagopyrum dibotrys, 10g Phragmites communis, 6g Amomum villosum, and 3g Bletilla striata. Depending on clinical diagnosis, other herbs such as Cornus officinalis, Trichosanthes kirilowii, Lophatherum gracile, Paeonia suffruticosa, and Poria cocos may be selectively added. The preparation method includes two decoctions, filtration, and combining the filtrates. It is derived from the Kidney-Nourishing, Heat-Clearing, and Yin-Nourishing Decoction, retaining the core of the Fluid-Increasing Decoction, and adding three lung / stomach meridian-invigorating herbs: Fagopyrum dibotrys, Phragmites communis, and Bletilla striata. The core treatment principle is to nourish yin and generate fluids, clear heat and remove blood stasis, promote tissue regeneration and wound healing, and harmonize the spleen and stomach. Clinical observation shows that it can significantly reduce the VAS score for dry mouth in patients with Sjögren's syndrome, increase static salivary flow rate, and promote the recovery of oral mucosal ulcers and angular cheilitis. It has good safety and can be taken orally for overall conditioning or used as a mouthwash to directly target the affected area.

The utility model discloses an oral cavity support for radiotherapy positioning in the department of radiotherapy, which relates to the field of medical instruments and comprises an oral cavity support. The tongue depressor comprises an upper arch groove, a lower arch groove is formed in one end of the upper arch groove, the upper arch groove and the lower arch groove are connected through two rotating shafts, reset springs are symmetrically installed at the bottom of the lower arch groove, and a tongue depressor is installed at the bottoms of the reset springs which are symmetrically arranged. The two fixing assemblies are symmetrically arranged, and the fixing assemblies are installed between the upper arch groove and the lower arch groove; the clamping assembly is mounted in the lower arch groove; the oral cavity support for radiotherapy positioning in the radiotherapy department is convenient, a patient does not need to see a doctor in the stomatology department, and the oral cavity support can be operated and worn by himself / herself. The fixing precision and repeatability of the upper jaw, the lower jaw and the tongue are improved, so that adverse reactions such as oral mucositis, gustatory disorder and xerostomia are reduced; the fixing precision is improved while individualization is achieved through the oral cavity support, occlusion and wearing of a patient are facilitated, the manufacturing method is simple, and clinical quantitative popularization is facilitated.

A post-operation xerostomia nursing device for oral patients relates to the technical field of fluid conveying devices for human bodies and comprises a water storage bag body, a water conveying pipe, a connector and a water storage part, water is contained in the water storage bag body, the upper end of the water conveying pipe is communicated with the water storage bag body, and the lower end of the water conveying pipe is communicated with the connector. One end of the connector communicates with the interior of the water storage part, a containing cavity is formed in the connector, an opening of a rectangular structure is vertically formed between the interior of the containing cavity and the left side face, and fixing pieces are arranged on the right side of the opening along the top end face of the inner wall of the connector at intervals; through cooperation of an upper abutting plate, a lower abutting plate, a water outlet and a connector, a patient can autonomously control the water outlet state of a water storage piece, in actual use, the patient can extrude or loosen the upper abutting plate and the lower abutting plate by means of oral movement, and therefore a water diversion pipe and a connecting plate in the connector can be driven to move; after action, flexible switching between a conventional water delivery mode and a large-water-volume mode can be achieved, the design can meet the rapid water replenishing requirement when the oral cavity is extremely dry, conventional water output can be recovered when a large amount of water is not needed to be replenished, and therefore the real-time dry mouth condition of a patient can be accurately adapted.

The invention belongs to the technical field of health-care food, and particularly relates to a medicated diet composition for improving eyesight, regulating spleen and increasing memory as well as a preparation method and application thereof. The medicated diet composition comprises the following raw materials in parts by mass: 9-45 parts of dried snow pears, 6-30 parts of lily bulbs, 3-15 parts of radix codonopsis, 2-10 parts of dried orange peel, 1-5 parts of dried ginger and 3-15 parts of mulberries. The medicated diet composition starts from regulating five internal organs, and gathers force in the liver and the spleen through delicate compatibility and the effect of promoting generation of the five internal organs, so that the effects of improving eyesight, regulating the spleen and increasing memory can be achieved, the efficacy can be lasting, meanwhile, cold and heat purgation and tonification are balanced through medicinal compatibility, and the defect that traditional tonics are poor in nature is overcome. Clinical tests show that the medicated diet composition can effectively improve the clinical symptoms such as eye dryness, eye itching, frequent blinking, memory deterioration, dry mouth or dry throat, poor appetite and the like of patients with liver and kidney deficiency and spleen and stomach deficiency in the sub-health state, and the life quality of the patients is improved.

To provide a composition capable of exhibiting new effects of bay laurel (LaurusnobilisL.).SOLUTION: The composition contains an extract of bay laurel (LaurusnobilisL.), has an antibacterial action against Tannerellaforsythensis and Streptococcusmutans, suppresses gingival inflammation, spontaneous bleeding of gums and plaque accumulation, improves dryness in the oral cavity and saliva pH, suppresses halitosis and improves constipation. Specifically, the present invention relates to an antibacterial agent against periodontal disease-related bacteria and dental caries-related bacteria, a composition for preventing or treating periodontal disease, a composition for preventing or treating dental caries, a composition for improving gingiva, a composition for improving gums, a composition for suppressing plaque (dental plaque) accumulation, a composition for improving xerostomia, a composition for improving saliva, a composition for suppressing halitosis, and a composition for improving constipation, each of which contains a bay laurel (LaurusnobilisL.) extract as an active ingredient. By containing the bay laurel (LaurusnobilisL.) extract, it is possible to suppress Tannerellaforsythensis and Streptococcusmutans which are periodontal disease-related bacteria, suppress gingival inflammation, spontaneous bleeding of gums, and plaque accumulation, improve dryness in the oral cavity and saliva pH, suppress halitosis, and improve constipation.SELECTED DRAWING: None

The application provides a traditional Chinese medicine composition for treating or improving Sjogren's syndrome, and belongs to the technical field of traditional Chinese medicine pharmacy.The traditional Chinese medicine composition takes asparagus, lily and mulberry as monarch drugs, takes honeysuckle, semen astragali, rush and radix codonopsis as minister drugs, takes turmeric and atractylodes as auxiliary drugs, and takes licorice as a guide drug, and the drugs are combined to have the effects of nourishing yin and moistening dryness, clearing heat and dredging collaterals, tonifying qi and invigorating the spleen, and promoting blood circulation and improving eyesight.The traditional Chinese medicine composition can significantly reduce the water consumption of NOD mice, increase the saliva amount of NOD mice, significantly down-regulate the levels of inflammatory factors TNF-alpha, IL-17 and IL-1beta in the serum of NOD mice, improve the gland structure and lymphocyte infiltration in the submandibular gland tissue of NOD mice, and reduce the submandibular gland injury.In addition, the traditional Chinese medicine composition can significantly reduce the ESSDAI and ESSPRI scores of Sjogren's syndrome patients, improve the clinical symptoms such as dry mouth, dry eyes and salivary gland swelling of the patients, has a high total effective rate in clinical treatment, and can be further developed and researched as a drug for treating Sjogren's syndrome.

The Interchangeable Mechanical Covering Device for Dental Unit with Digital Counter and Suction Volume Regulator in Suction is designed to address two fundamental challenges in clinical environments: firstly, the manual and unhygienic replacement of the unit covering, which leads to cross-contamination; and secondly, the fixed and unintelligent regulation of saliva suction intensity, which can cause patient dry mouth and disrupt the treatment process. This device utilizes a hands-free mechanical covering replacement mechanism, a pulling motor, a digital counter, a waste collection tank, a suction system connected to an adjustable pump, a touchscreen display, and a central processor. It automates the covering and suction processes, making them recordable and adaptable to treatment conditions. The innovation of this idea lies in the simultaneous combination of these two functions, the capability to store performance data, and the elimination of reliance on human intervention.

The invention provides a dry mouth nursing device for anesthetized patients, the dry mouth nursing device for anesthetized patients comprises an atomization module, a shield, a side wetting module and a bottom wetting module, the atomization module is connected with the side wetting module and the bottom wetting module through an air pipe, and the air pipe penetrates through the shield; the two side face wetting modules are symmetrically arranged on the two sides of the bottom wetting module, an atomization unit and a detection unit are arranged in the atomization module, and a control unit is arranged in the protective cover. According to the invention, sampling detection is carried out through the detection sensor, the humidity in the oral cavity is determined, automatic wetting control is carried out according to the humidity, the oral cavity is wetted timely and effectively without assistance of other people, and the nursing cost and labor are reduced.

Liquid formulations including cevimeline hydrochloride and a combination of at least one sweetener and at least one flavoring agent to mask the bitter taste of the cevimeline hydrochloride when formulated for oral administration. A taste masking composition that masks the bitter taste of cevimeline hydrochloride when formulated for oral administration, wherein the taste masking composition includes two or more sweeteners and two or more flavoring agents. Liquid formulations including cevimeline hydrochloride and the taste masking composition. The liquid formulations including cevimeline hydrochloride may be administered to a patient to alleviate dry mouth symptoms associated with xerostomia and Sjogren's syndrome.

The invention discloses a saliva flow rate detection strip for auxiliary diagnosis of xerostomia and a detection method thereof. The detection strip comprises strip-shaped filter paper pretreated by fluorescein sodium, the filter paper is packaged in a food-grade plastic shell, one end of the filter paper extends out of the shell to form a 0.5 cm sampling part, and scale marks are arranged on the filter paper. During detection, the sampling part is placed under the tongue for 3 minutes, saliva infiltrates along the filter paper under the capillary action and dissolves the fluorescein sodium for color development, and the flow rate of the unstimulated saliva can be obtained through conversion by reading the infiltration length. The detection strip can effectively distinguish a control person from a sicca syndrome patient, a xerostomia patient and the like. The problems that a traditional method is long in consumed time, poor in experience and inconvenient to operate are solved, and a detection tool which is rapid, objective and standardized and is in seamless butt joint with an existing diagnostic standard is provided.

The present application belongs to the field of health food, and particularly relates to a spleen-invigorating and dampness-expelling medicinal and edible composition, a preparation method thereof and application. The medicinal and edible composition comprises, in mass parts, radix codonopsis 3-30 parts, lotus seed 5-40 parts, coix seed 10-40 parts, gordon euryale seed 10-40 parts, dried tangerine or orange peel 1-15 parts and medlar 5-30 parts. The present application is aimed at people with spleen deficiency and dampness, mainly manifested as body obesity, heavy hands and feet or head and body, tasteless or dry mouth, loose or rotten stool, etc. The present application adopts the method of TCM syndrome differentiation and treatment, invigorates the spleen and expels dampness, and stops diarrhea by astringing the intestines. Meanwhile, the present application takes into account the congenital basis and adjusts kidney yang. The spleen-invigorating and dampness-expelling medicinal and edible composition can effectively improve the symptoms of people with spleen deficiency and dampness, such as body obesity, heavy hands and feet or head and body, tasteless or dry mouth, loose or rotten stool, etc.

The invention discloses a method for detecting mouth dryness, which is characterized in that test paper is used for detection, the test paper comprises a plurality of detection layers, and the detection layer on the outer side wraps the other detection layers in sequence, so that the whole body is in a water drop shape; the color developing layer adopts a starch coating, can be subjected to specific biochemical reaction with a specific marker in saliva, is only sensitive to'saliva marker abnormity 'caused by pathology or drugs, and is not interfered by drinking water physiological factors; compared with the traditional humidity measurement principle, the problem of misjudgment of physiological thirst is solved.