The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds—Free-B-Ring flavonoids and flavans—for use in the prevention and treatment of diseases and conditions associated with mouth, gums and teeth. This composition of matter simultaneously inhibits 
cyclooxygenase (COX) and 
lipoxygenase (LOX) enzymatic activity and reduces 
cytokine production at the 
mRNA level in normal, aged and damaged periodontal cells and tissues. This invention further provides a method for the prevention and treatment of diseases and conditions of the mouth, gums and teeth. The method for preventing and treating diseases and conditions of the mouth, teeth and gums is comprised of administering to a host in need thereof a therapeutically effective amount of a composition comprising a mixture of Free-B-Ring flavonoids and flavans synthesized and / or isolated from a 
single plant or multiple plants, preferably in the 
Scutellaria, Oroxylum, 
Acacia or 
Uncaria genus of plants and pharmaceutically and / or cosmetically acceptable carriers. Finally the present invention provides a method for the prevention and treatment of diseases and conditions of the mouth, teeth or gums, including but not limited to periodontal diseases, such as 
gingivitis, 
periodontitis, 
pulpitis, periodontal conditions caused by the physical implantation of oral 
dentures, trauma, injuries, bruxism, neoplastic and other degenerative processes; material alba, pellicles, dental plagues, calculus, and stains. Use of the composition described herein also affords the benefit of maintaining optimum 
saliva production and pH, minimizing 
bacterial growth, reducing the formation of pellicles and plague, inhibiting tooth decalcification and 
tooth caries (decay), promoting remineralization, which yields healthy gums, whitening teeth, maintaining healthy 
oral hygiene and reducing oral malodour (halitosis).