Carsickness is a disease caused by stimulating the vestibular nerve of the human body by jolt or swing or rotating or other acceleration motions of any form generated during movement of automobiles or ships or planes. A patient feels epigastric discomfort at first, then nausea, pale complexion and cold sweat happen, and then dizziness, deprementia, salivary secretion increase and emesis happen. A medicine is formed by combining selected rhizoma atractylodis, lysimachia foenum-graecum, fructus amomi, musk, endothelium corneum gigeriae galli, borneol, rice sprouts, storax, semen raphani, rhizoma acori graminei, fructus citri, ginseng, fingered citron, American ginseng, pericarpium citri reticulatae viride, honey, orange peel, rhizoma atractylodis macrocephalae, inula flowers, maltose, polygala roots, English walnut seeds, spina date seeds, herba cistanche, gall nuts, polygonum multiflorum, light wheat, radix ophiopogonis, Glycine max (L.) Merr. Shells, lily flowers, cassia seeds and the fruit of Chinese wolfberries. According to the medicine combination, the effects of all the medicine materials achieve the synergistic effect, and therefore carsickness can be effectively treated.