12 results about "Salivary secretion" patented technology

The utility model discloses a blowing nozzle structure for lung function testing, which comprises a blowing nozzle cover body, a connecting pipe capable of filtering blown air is arranged at the bottom of the blowing nozzle cover body, a filter screen is arranged in the connecting pipe, a detachable auxiliary blowing pipe is arranged in the blowing nozzle cover body and corresponds to the position of the connecting pipe, and the auxiliary blowing pipe is connected with the connecting pipe. The bottom of the connecting pipe is fixedly connected with a connecting nozzle used for being connected with the connecting pipe. According to the lung function instrument, the filter screen is arranged, air blown out by a patient can be effectively filtered, so that impurities such as saliva and secretions in exhaled air are effectively prevented from entering the lung function instrument, cross infection is effectively prevented, meanwhile, the detachable auxiliary blowpipe is arranged, and the auxiliary blowpipe can be conveniently used according to the requirements of the patient. When the blowing nozzle is used, the auxiliary blowing pipe is inserted into the connecting pipe to blow air in the mouth, or the auxiliary blowing pipe can be pulled out, and the blowing nozzle cover body covers the mouth to blow air, so that the use flexibility of the blowing nozzle is improved.

The invention discloses an application of bead exosome-like nano-vesicles in treatment of Sjogren's syndrome. The bead exosome-like nano-vesicle is prepared through a differential centrifugation method and an ultracentrifugation method, and toxicological evaluation shows that the bead exosome-like nano-vesicle has good safety and can be used for in-vivo and in-vitro treatment. In-vivo experiments prove that the Sjogren's syndrome model mouse treated by the bead exosome-like nano-vesicles has significantly increased salivary secretion and significantly improved dry mouth symptom; in-vitro experiments further show that the nano vesicles can also significantly improve the activity and the water secretion function of salivary gland epithelial cells in the Sjogren's syndrome. The exosome-like nano-vesicles are successfully extracted from bead leaves and are creatively used for treating the Sjogren's syndrome, and a brand new thought and a material source are provided for research and development of medicines for treating the Sjogren's syndrome.

The invention discloses an application of a Pik3cb inhibitor in treatment of Sjogren's disease. Experiments prove that the Pik3cb inhibitor TGX-221 can reduce the number, activation and chemotaxis of NOD mouse B cells of a Sjogren's disease model mouse, plasma cell differentiation and antibody secretion, improve the immune microenvironment of the submaxillary gland of the Sjogren's disease model mouse, reduce the infiltration degree of submaxillary gland lymphocytes and promote the salivary secretion function; and after the Pik3cb is over-expressed, the symptom and pathology of the Sjogren's disease are aggravated. Therefore, the Pik3cb inhibitor can be used for treating the Sjogren's disease. The invention provides a new thought for research and development of medicines for treating the Sjogren's disease, and has important application value.

The invention relates to application of enzyme modified isoquercitrin. The present invention provides a salivary secretion stimulator having a dosage form usable in the oral cavity or a dosage form usable by oral administration (dosage form for oral cavity, dosage form for oral administration). The salivary secretion stimulating agent may be prepared using an enzyme modified isoquercitrin or a combination of an enzyme modified isoquercitrin and a thickening polysaccharide. The invention also provides an additive (an additive for oral compositions), the composition is effective for preparing an oral composition (a food or beverage, pharmaceutical product for oral administration) and can impart at least one activity selected from the group consisting of salivary secretion stimulating activity, swallowing improving activity (swallowing assisting activity) and chewing improving activity (chewing assisting activity) to the oral composition. The additive may be prepared using an enzyme modified isoquercitrin in combination with a thickening polysaccharide.

The utility model discloses a tongue depressor for physical examination of infants, which comprises a depressor handle, a depressor body is fixedly arranged at one end of the depressor handle, a depressor head is mounted at one end of the depressor body far away from the depressor handle, the depressor head, the depressor handle and the depressor body are all made of silica gel materials, and the depressor head is heart-shaped and is matched with a tongue tip anatomical structure. The top and the bottom of the plate head are each fixedly provided with a plurality of first anti-skid protruding points, the plate handle and the plate body are integrally formed, the two sides of the plate handle are each provided with a holding groove, the holding grooves are in an arc shape, and the top and the bottom of the plate handle are each fixedly provided with a plurality of second anti-skid protruding points. The tongue depressor solves the problems that a traditional tongue depressor is simple in shape design, usually in a flat long strip shape, not matched with the anatomical structure of the tongue tip of an infant, difficult to accurately press the tongue tip in the using process, smooth in surface, prone to slipping in the using process due to salivary secretion of the infant and the like, and affects examination.

The invention discloses a sucking screw for oral and labial muscle training, and particularly relates to the field of oral and labial muscle training.The sucking screw comprises a shell, the shell is in a screw shell shape, a smooth pipeline is arranged in the shell, and the smooth pipeline is coiled in a screw shell shape; the piston is arranged in the smooth pipeline, and the diameter of the piston is the same as that of the inner wall of the smooth pipeline; and the top cover is installed at the top end of the shell, a connecting assembly is arranged at the bottom end of the top cover, and the bottom end of the top cover is detachably connected with the top end of the shell. The device can actively cooperate with a treated patient, the suction ability training is dominated, the blowing function is assisted, the lip closing function and the tongue muscle activity ability can be directly trained through the suction function training, salivary secretion can be promoted through suction, swallowing reflex can be induced, and the swallowing function is indirectly trained; through the training of the blowing function, the strength and endurance of cheek muscles can be exercised.

The invention provides a bio-enzyme-based compound, a preparation method thereof and application of the bio-enzyme-based compound in toothpaste, and belongs to the technical field of toothpaste. Covalent coordination of metal ions and tannic acid is utilized, a compound enzyme is entrapped in a core, then the compound enzyme, an edible blue pigment and plant essential oil are embedded in a microcapsule, a surfactant is bonded on the surface of the microcapsule, and the microcapsule is coupled with a chicken egg yolk immunoglobulin G antibody and casein phosphopeptides to prepare the biological enzyme-based compound. The biological enzyme-based compound prepared by the invention can well protect the form of the compound enzyme, exerts the effect of synergistically inhibiting oral bacteria, improves the foamability of the toothpaste, promotes the compound enzyme to be uniformly and quickly attached to the tooth surface, plays a long-acting antibacterial role, can promote the calcium utilization of the teeth, stimulates salivary secretion, and improves the tooth quality. And the dental caries can be prevented, and the application prospect is wide.

The invention belongs to the technical field of tobacco products, and relates to a preparation method of a non-woven fabric buccal cigarette containing a saliva engendering agent. The non-woven fabric containing the saliva engendering agent is placed in the oral cavity, saliva immerses into the non-woven fabric, an acid source and an alkali source are in contact reaction, fine carbon dioxide bubbles are generated, and a unique bubbling feeling is brought. Meanwhile, reaction by-products and built-in buffer salt jointly form a buffer pair, so that the local pH of the oral cavity can be stabilized, and stimulation caused by over-acidity or over-alkalinity is avoided. Nicotine particles are dissolved through saliva, sodium bicarbonate is continuously released, the sodium bicarbonate and organic acid in the oral cavity are shown, gas is continuously generated, saliva engendering power which exceeds single chemical stimulation and is closer to natural food is provided, and the effect runs through the whole service cycle. The generated trace CO2 bubbles perform physical massage on salivary glands and mucous membranes, and cooperate with chemical stimulation of organic acid to activate salivary secretion from multiple dimensions, so that the user experience is richer and more natural. Meanwhile, a benign chemical cycle is formed in the system, the local mild pH environment of the oral cavity is maintained, and the comfort level is improved.

This invention discloses the application of geraniol in the preparation of a drug for treating Sjögren's syndrome. In vivo experiments using a NOD mouse model of Sjögren's syndrome demonstrated that geraniol treatment significantly improved salivary secretion disorders and reduced abnormally high water intake in the mice; significantly reduced lymphocyte infiltration in salivary gland tissue, improved glandular pathological damage, downregulated the levels of characteristic autoantibodies (Anti-SSA / Ro and Anti-SSB / La) in serum, upregulated the expression levels of AQP5 and AR, and reduced organ indices in salivary glands, spleen, and thymus tissue, comprehensively improving dry mouth symptoms in mice. In vitro experiments also showed that geraniol treatment upregulated the expression levels of AQP5 and AR. Therefore, this invention provides the application of geraniol in the preparation of a drug for treating Sjögren's syndrome, which has the advantages of significant efficacy and addressing both the symptoms and root cause, and possesses good clinical application prospects.

The utility model discloses an anti-allergy whitening tooth paste which comprises a backing layer, an upper tooth paste body is distributed on the backing layer, a lower tooth paste body is arranged on one side of the upper tooth paste body, anti-skid protruding lines are formed on the surface of the upper tooth paste body, a plastic film layer is arranged at the inner upper end of the upper tooth paste body, and active allergy protection factors are sprayed on the surface of the plastic film layer. Mint essence particles are adhered to the bottom end of the plastic film layer, whitening factor particles are arranged among the mint essence particles, and a gel layer is arranged below the whitening factor particles. The anti-slip tooth paste has the beneficial effects that the anti-slip convex grains are additionally arranged on the surfaces of the upper tooth paste and the lower tooth paste, so that the contact area with an oral cavity is reduced, meanwhile, salivary secretion is reduced by utilizing released active allergy protection factors, and meanwhile, the discomfort of a user is reduced, so that the use comfort and the use effect of the tooth paste are improved.

The invention discloses a sicca syndrome marker HMGB1 and application thereof, belongs to the field of biological medicine, and particularly relates to application of sicca syndrome marker high-mobility group protein B1 in diagnosis and treatment of sicca syndrome. The invention discloses that the expression of HMGB1 in salivary gland tissues of SS patients is obviously increased, the transcriptional level of key aquaporin AQP5 related to salivary secretion is obviously reduced, and the expression of HMGB1 is in negative correlation with the expression of AQP5. The invention also discloses application of the glycyrrhizin to inhibition of transcription or expression of the HMGB1 gene, and the glycyrrhizin is used as a sicca syndrome treatment preparation. The invention provides a potential new target for diagnosis and treatment of sicca syndrome, and has important clinical application value.

The invention discloses a salivation promoting powder buccal cigarette which is composed of the following components in percentage by weight: 30%-55% of microcrystalline cellulose, 5%-15% of a salivation promoting powder formula, 1%-10% of a humectant, 1%-20% of a flavoring agent, 0.5%-6% of an acid-base regulator, 1%-30% of nicotine salt and 35%-60% of water. The sum of the weight percentages of the microcrystalline cellulose, the salivation promoting powder formula and the humectant is not higher than 60%, and the weight percentage ratio of the salivation promoting powder formula to the nicotine salt is 1: (1.5-2.5). 10% of the body fluid generating powder is added, the effect is remarkable, various plant components (such as plums, dendrobium nobile, radix ophiopogonis and fructus phyllanthi) in the body fluid generating powder have a synergistic effect, salivary secretion is stimulated, and the body fluid generating feeling fed back by a user is improved by 60% or above; plum and liquorice effectively provide salivation promoting and sweet aftertaste taste; the formula of the salivation promoting powder is cooperated with the humectant, so that the moist feeling of buccal cigarettes is prolonged, and the oral dryness is reduced.