The invention discloses application of mesenchymal stem cells derived from an in-vivo
stem cell generator. The mesenchymal stem cells are used for preparing drugs for treating inflammatory diseases, especially inflammatory
enteritis. According to the method, an artificial controllable inflammatory microenvironment is constructed
in vivo through a
stem cell generator, so that the
immune regulation function of the mesenchymal stem cells is activated, and the activated MSC can effectively promote
phenotype conversion from M1 type macrophages to M2 type macrophages, induce T cells to be differentiated into regulatory T cells and inhibit proliferation of the activated T cells. In the treatment of mouse
inflammatory bowel disease, the MSC obtained by the method disclosed by the invention obviously improves the
survival rate of mice, relieves
weight loss, retains a relatively complete crypt structure of a colon part, inhibits infiltration of inflammatory cells to the colon, and rebuilds an inflammatory microenvironment of the colon. The invention provides a brand new method for activating the immunomodulatory function of the mesenchymal stem cells, and a new path is opened up for treating inflammatory and immune diseases.