36 results about "Gamma-Tocopherol" patented technology

A hair care formulation for improving the tensile strength of damage hair is provided, comprising: (a) a dermatogically acceptable vehicle; and (b) a tensile strength improving additive; wherein the tensile strength improving additive comprises: (b1) a (±)-α-tocopherol; and (b2) a carboxy functional organosiloxane compound of formula (I) wherein x is 0 to 25; wherein each R1 is independently selected from an alkylene radical containing 1 to 10 carbon atoms; wherein each R2 is independently selected from the group consisting of an alkyl group of 1 to 18 carbon atoms, an aryl group of 6 to 18 carbon atoms, an acyloxy group of 2 to 18 carbon atoms, and a hydrocarbonoxy-functional group of 1 to 18 carbon atoms.

The antioxidant activity of alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and of alpha-tocopherol succinate (TS) has been examined in isolated hepatocytes and microsomal fractions from rat liver. Both TPGS and TS require esterase activity to yield free alpha-tocopherol and, hence, antioxidant activity. TPGS and TS consistently exerted a more effective antioxidant protection than an equivalent amount of directly-added free alpha-tocopherol. The low antioxidant efficiency of directly added free alpha-tocopherol in such water-based experimental systems as used here seems to be due to its extreme hydrophobicity. TPGS, on the other hand, is an extremely hydrophilic compound which is being examined as a useful source of alpha-tocopherol in certain clinical situations and is here shown to be a convenient and effective source for experimental studies into lipid peroxidation and antioxidant mechanisms.

The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.

This application provides a vanadium-based catalyst and its application. The catalyst includes a main catalyst, a co-catalyst, and a porous support. The main catalyst and the co-catalyst are dispersed on the porous support. The main catalyst includes vanadium and optionally molybdenum, and the co-catalyst includes fullerene. Using this vanadium-based catalyst to catalyze the methylation reaction of mixed tocopherols to produce D-α-tocopherol can effectively improve the yield and content of D-α-tocopherol.

The invention discloses an immunogenic composition containing gE nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biomedicine, the immunogenic composition comprises self-assembled gE nanoparticles and an oil-in-water emulsion adjuvant, and a self-assembled gE nanoparticle antigen comprises gE, a connecting peptide SGS and a gI polypeptide sequence containing Th epitopes; the oil-in-water type emulsion adjuvant is prepared from squalene, Tween 80, DL-alpha-tocopherol and / or Span 85. The immunogenic composition provided by the invention can be applied to vaccines for preventing varicella and / or herpes zoster and / or postherpetic neuralgia, so that the aims of improving the immunogenicity of the gE antigen and reducing side effects of the vaccines are fulfilled.

The invention relates to a rice grading processing and food preservation technology, and discloses a stabilization processing method for rice aleurone layer component powder. The method sequentially comprises the following steps: adding 30-40% of water, and carrying out colloid milling to 70-100 meshes; filling the materials into a pressure-resistant bag, wherein the bag volume is 50-80% of the bag volume, and sealing after air is exhausted; water is used as a pressure transmitting medium, and ultrahigh pressure treatment is conducted for 100-300 s under the pressure of 500-650 MPa; plate type thin film drying is carried out, the coating thickness is 0.8-1.2 mm, the temperature is 120 + / -5 DEG C, the time is 30 + / -5 s, and the thickness is 0.8-1.2 m.s <-1 >; and cooling, crushing and sieving to obtain powder. The residual lipase activity of the obtained product is less than or equal to 8%, the retention rate of alpha-tocopherol is greater than or equal to 85%, the retention rate of oryzanol is greater than or equal to 88%, and the acid value is less than or equal to 40mgKOH / 100g after the product is stored for 12 months at The method is short in thermal history, quantifiable in parameter and suitable for industrial amplification.

The application discloses a SNP marker related to wheat kernel alpha-tocopherol content and application thereof. The application provides application of a substance for detecting a SNP site Ta-6A-SNP haplotype in a wheat genome in any one of the following: A1) identifying or assisting in identifying wheat kernel alpha-tocopherol content; A2) screening or assisting in screening wheat with high alpha-tocopherol content in kernels; A3) breeding wheat with high alpha-tocopherol content in kernels; A4) wheat genetic breeding. The application finds a SNP site Ta-6A-SNP on a 6A chromosome of wheat, and develops a molecular marker according to the SNP, which is a KASP marker, has good repeatability, low cost, is beneficial to screening wheat varieties with high alpha-tocopherol content, and has important significance for cultivating new wheat varieties with high alpha-tocopherol content.

The application belongs to the technical field of functional food additives, and relates to a D-alpha-tocopherol and gamma-aminobutyric acid co-crystal as well as a preparation method and application thereof. The co-crystal is prepared from D-alpha-tocopherol and gamma-aminobutyric acid through a co-crystallization technology, has a clear crystal structure, and has characteristic peaks in an X-ray diffraction pattern and a unique melting point in a differential scanning calorimetry pattern. The co-crystal can convert oil-like D-alpha-tocopherol into a solid form with good powder property, significantly improve storage stability and oil loading, and has no bad odor, and is easy to be accepted by consumers. The application further provides a co-crystal composition containing acceptable adjuvants, the composition has the same crystal type characteristics as the co-crystal, and further expands application adaptability. The preparation method adopts steps of solvent mixing, heating reaction, low-temperature crystallization, centrifugal drying and the like, is mild in condition, simple in process, and suitable for industrial production.

The invention provides a vancomycin hydrochloride-containing pharmaceutical composition and a preparation method thereof, the pharmaceutical composition is prepared from vancomycin hydrochloride, PEG6000 and DL-alpha-tocopherol, nitrogen is continuously introduced in the preparation process of the pharmaceutical composition, the whole pharmaceutical composition has simple auxiliary materials and only two auxiliary materials, and the prepared pharmaceutical composition has low content of related substances and is suitable for clinical application. The vancomycin hydrochloride hard capsule is simple in preparation method, high in stability and low in cost, DL-alpha-tocopherol is adopted as an auxiliary material, the prepared vancomycin hydrochloride hard capsule reduces degradation and oxidation of vancomycin hydrochloride, the problem that vancomycin hydrochloride is poor in stability is solved, and the whole preparation method is simple, convenient to operate and suitable for industrial large-scale production.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of tocopheryl glycoside. According to the method, tocopherol monomers and acetylated glycosyl donors are used as raw materials, and stereoselective glycosylation coupling is performed under the action of scandium trifluoromethanesulfonate and / or ytterbium trifluoromethanesulfonate, so that tocopherol glycoside can be obtained with high yield and high stereoselectivity. The method has the advantages of high utilization rate of tocopherol, mild reaction conditions, high product purity and safe reaction and post-treatment steps, and is suitable for large-scale production.

A method for determining a combined amount of β-tocopherol and γ-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the β-tocopherol and γ-tocopherol detectable by mass spectrometry; and determining the amount of one or more of said ions by tandem mass spectrometry, wherein tandem mass spectrometry comprises fragmenting β-tocopherol and γ-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions comprising a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of β-tocopherol and γ-tocopherol in the sample.

The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.

A method for spectrophotometric detection of γ-tocopherol in a sample, comprising mixing the sample with a reagent composition in a solvent to form a mixture; incubating the mixture; measuring absorbance of the mixture; and correlating the measured absorbance to γ-tocopherol concentration in the sample.

A method for determining a combined amount of β-tocopherol and γ-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the β-tocopherol and γ-tocopherol detectable by mass spectrometry; and determining the amount of one or more of the ions by tandem mass spectrometry. Tandem mass spectrometry methods of this disclosure involve fragmenting β-tocopherol and γ-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions including a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of β-tocopherol and γ-tocopherol in the sample.

The application discloses an EPA liposome and a preparation method and application thereof, and particularly relates to the technical field of cosmetics. The EPA liposome is prepared through self-assembly of liposomes by using the following raw materials in parts by mass: microalgae oil EPA 1-4 parts, epicatechin-3-gallate 1-2 parts, alpha-tocopherol 0.2-1 part, ginsenoside Rg3 0.02-0.1 part, lipids 2-10 parts, emulsifier 1-10 parts, and water is supplemented to 100 parts. The EPA liposome realizes the stable effect of EPA in a composite system such as a cosmetic skin care product, enhances the in-situ antioxidant and protective functions of EPA and slows down the autoxidation of EPA, improves the bioavailability and enhances the anti-aging effect through the synergy of the contained efficacy substances and the design of the nano-liposome.

This invention relates to the field of vaccine adjuvant technology, and discloses an oil-in-water adjuvant containing squalene and α-tocopherol, its preparation method, and its application. The preparation method includes the following steps: mixing squalene, α-tocopherol, and poloxamer to obtain an oil phase mixture; subjecting the oil phase mixture to high-speed shearing with an aqueous phase to obtain a pre-emulsion; and subjecting the pre-emulsion to high-pressure homogenization to obtain the oil-in-water adjuvant. This invention, through the synergistic effect of α-tocopherol and poloxamer, combined with a specific preparation process, solves the problems of poor stability and uneven particle size distribution in existing adjuvants. The adjuvant prepared by this invention exhibits excellent long-term physicochemical stability, with a Z-average particle size in the range of 100-300 nm and a polydispersity index (PDI) of less than 0.25, demonstrating good immunostimulant carrying capacity and immune enhancement effect.

The invention relates to the technical field of biological and pharmaceutical preparations, and discloses an AS04 adjuvant composition for a vaccine as well as a preparation method and application of the AS04 adjuvant composition. The preparation method comprises the following steps: preparing 3-O-deacyl-4 '-monophosphoryl lipid A A polymer stabilizer; squalene; the preparation method comprises the following steps: S1, carrying out mixed adsorption on 3-O-deacyl-4'monophosphoryl lipid A and aluminum hydroxide, so as to prepare an adjuvant base core; s2, squalene and alpha-tocopherol are mixed and dissolved, and an oil phase premix is prepared; s3, dropwise adding the oil phase premix into the adjuvant-based core suspension under a low shearing force; s4, adding a polymer stabilizer solution into the mixture to carry out polymer coating; and S5, freeze-drying the final mixture. By sequentially constructing a multi-layer protection structure, the AS04 adjuvant is endowed with excellent freeze-drying stability, rapid redissolving performance and antigen activity protection effect.

This invention discloses a strain of *Enterobacter cloacae* EC11 and its applications, belonging to the field of microbial technology. The strain is classified as *Enterobacter cloacae* EC11, with the accession number CCTCC NO:M 2025610. This strain exhibits a hydrolysis zone HC value of 3 on tributyrate agar plates and a lipase activity of 145.28 U / mL. This invention also provides the application of this strain and its produced lipase in the catalytic hydrolysis of tocopherol succinate to prepare tocopherol. The crude enzyme solution obtained by fermenting the lipase strain EC11 was added to a reaction system containing tocopherol succinate for hydrolysis. After 9 hours of reaction, the tocopherol content was increased by 725% compared to the control group. The strain and method provided by this invention have high catalytic efficiency, mild reaction conditions, and are environmentally friendly, making them suitable for the green industrial production of tocopherol.

The present invention provides a food colouring composition, in particular the invention provides a composition or colouring composition comprising at least one Polyketide pigment (i) and one or more of the following compounds (ii) a carotenoid (such as lycopene, bixin and / or norbixin), rosmarinic acid, a chlorogenic acid, rutin glucoside, (gamma) cyclodextrin and / or a tocopherol.

The invention relates to high-purity tocopherol glucoside and a synthesis method thereof, and belongs to the technical field of organic synthesis. The technical problems that an existing synthesis method of tocopherol glucoside is low in yield and poor in stereoselectivity, oxidation by-products are generated, tocopherol is excessively used, and toxic metal reagents are used are solved. The synthesis method comprises the following steps: dissolving a tocopherol monomer and alpha-D-fluoroglucopyranose in a water-containing mixed reagent, carrying out a glycosylation reaction under the action of an alkaline reagent, after the reaction is finished, extracting a reaction product by using an organic solvent, washing, drying and concentrating an organic phase to obtain a crude product, recrystallizing the crude product by using an alcohol solvent, filtering, and drying to obtain the tocopherol-alpha-D-fluoroglucopyranose. The tocopherol glucoside is obtained. According to the synthesis method, only one-step reaction is needed, a protecting group removal step is omitted, the utilization rate of the tocopherol monomer is high, reaction conditions are mild, anhydrous glycosylation reaction conditions are not needed, post-treatment is convenient, the product yield is high, the purity is high, and the synthesis method is suitable for large-scale industrial production.

The invention discloses Korean pseudomonas STR7 and application thereof, and belongs to the technical field of microorganisms. The strain is classified and named as Pseudomonas koreensis STR7, and the preservation number of the strain is CCTCC (China Center For Type Culture Collection) NO: M 2025608. The HC value of a hydrolysis circle of the strain on a tributyrin plate is 3, and the lipase activity reaches 136.81 U / mL. The invention also provides application of the strain and the lipase produced by the strain in preparation of tocopherol by catalyzing hydrolysis of tocopherol succinate. The strain STR7 is fermented to obtain crude enzyme liquid, the crude enzyme liquid is added into a reaction system containing tocopherol succinate for hydrolysis reaction, and after the reaction is performed for 9 hours, the content of tocopherol is increased by 865% compared with that of a control group. The strain and the method provided by the invention are high in catalytic efficiency, mild in reaction condition, environment-friendly and suitable for green industrial production of tocopherol.

The application discloses a preparation method of bis-tocopheryl azelate and application thereof, and belongs to the technical field of compound synthesis. The application provides a preparation method of bis-tocopheryl azelate, and the yield and purity of bis-tocopheryl azelate are improved. The bis-tocopheryl azelate prepared by the application overcomes the limitations of poor permeability and high irritability of azelaic acid, and can also improve the overall efficacy through synergistic effect, so that a more optimal solution is provided for skin care and treatment.

We demonstrate that supplementation with resistant potato starch (RPS) influences the circulating levels of retinol, alpha-tocopherol, choline, and the choline-derived phospholipid sphingomyelin in serum. Levels of the toxic microbially transformed choline metabolites trimethylamine and trimethylamine oxide did not increase, suggesting that RPS may be an e ective way to enhance choline uptake without promoting increased toxic metabolite production. Increased hydroxysphingomyelin levels in RPS consuming individuals are particularly intriguing given the role these metabolites play in myelin.

The invention provides a preparation method of ionic liquid modified beta-cyclodextrin, which comprises the following steps: reacting beta-cyclodextrin with NaOH to obtain an activated beta-CD-O-Na < + > solution, then grafting with an imidazole ionic liquid, and after the reaction is terminated, washing and drying to obtain the ionic liquid modified beta-cyclodextrin. The invention also provides an application of the ionic liquid modified beta-cyclodextrin in separation of delta-tocopherol, especially separation of beta-cyclodextrin from mixed tocopherol. According to the method, the high-content and high-purity delta-tocopherol is obtained from the mixed tocopherol through efficient adsorption separation, the purity of the separated delta-tocopherol is larger than 90%, the recovery rate is larger than 80%, the regenerated ionic liquid modified beta-cyclodextrin can be repeatedly used, and the method is simple in process, low in cost and suitable for industrial production. The problems of serious environmental pollution, low separation efficiency and the like in the traditional process are solved, the cost is reduced, and large-scale industrial production is easy.

This invention relates to a recombinant photosynthetic bacterial strain with high tocopherol production, its construction method, and its applications. The recombinant strain knocks out the photosynthetic gene repressor transcription factor PpsR and integrates the mevalonate MEV pathway gene from *Paragonimococcus zeatans*, the p-hydroxyphenylpyruvate dioxygenase (HPPD) gene from *Pseudomonas putida*, the urokinase chlorophyllase (HPT) gene from *Synostemma pentaphyllum*, the tocopherol cyclase (TC) gene from *Arabidopsis thaliana*, and feedback-resistant 3-deoxy-D-arabinohepenoyl-7-phosphate synthase (AroG*). D146N Genes and prephenyl acid dehydrogenase TyrA* M53I Genes. This recombinant photosynthetic bacterium strain achieves highly efficient heterologous synthesis of tocopherol by knocking out regulatory genes and integrating multiple metabolic modules, with a fermentation yield of up to 3.51 g / L, showing broad prospects for industrial application.

The invention provides a tanshinone IIA nano compound, a brain-targeted drug system, a drug preparation and application. The tanshinone IIA nano-composite comprises (1) tanshinone IIA and (2) a nano-carrier entrapping the tanshinone IIA, the nano-carrier comprises a chitosan derivative, and the chitosan derivative is connected with D-alpha-tocopherol succinate; wherein the nano carrier is connected with the tanshinone IIA through a cross-linking agent. The brain-targeted drug system provided by the invention comprises RVG29 and the tanshinone IIA nano compound. The tanshinone IIA nanocomposite and the brain-targeted drug system can be used for preparing drugs for preventing or treating neurodegenerative diseases.

The application discloses a hybridoma cell strain secreting alpha-tocopherol monoclonal antibody and an application thereof, and belongs to the field of immune detection. The hybridoma cell strain secreting alpha-tocopherol monoclonal antibody is preserved in the China General Microbiological Culture Collection Center on April 18, 2024, and has a preservation number of CGMCC No.45925. The alpha-tocopherol monoclonal antibody secreted from the hybridoma cell strain can be used for immune analysis and detection, has good detection sensitivity and specificity for alpha-tocopherol, has an IC 50 value of 0.2 mu g / mL, has a cross rate of less than 1% for alpha-tocopherol analogs, can be used for preparing an immune detection product of alpha-tocopherol, and provides an efficient detection method and means for detection of alpha-tocopherol.

The main purpose of the present inventors is to provide a technique for suppressing inflammation, in particular, in aging tissues within the oral cavity.　The present inventors have found that an oral composition containing at least one selected from the group consisting of β-glycyrrhetinic acid, glycyrrhizic acid, ascorbic acid, tocopherol nicotinate, tocopherol acetate, pyridoxine, cobalamin, retinol, retinol acetate, riboflavin, phylloquinone, calciferol, anthraquinone, menaquinone-4, and L-aspartic acid, and chemically acceptable salts thereof, quercetin, genistein, fisetin, nobiletin, kaempferol, apigenin, and naringenin, and glycosides thereof, and methyl hesperidin can suppress inflammation, in particular, in aging tissues within the oral cavity.

The application discloses a nano-drug-loaded complex, a preparation method and application thereof. The nano-drug-loaded complex comprises a polymyxin antibiotic or a pharmaceutically acceptable salt thereof and an alpha-tocopherol-gallic acid conjugate. The polymyxin antibiotic or the pharmaceutically acceptable salt thereof and the alpha-tocopherol-gallic acid conjugate are self-assembled into a stable nano-complex through intermolecular non-covalent interaction.