68 results about "Gamma-Tocopherol" patented technology

The present invention relates to the mono-saponification of diesters of 2,3,5-trimethylhydroquinone by a base allowing an advantageous synthesis of esterified alpha-tocopherol. The mono-saponification has been demonstrated to occur very selectively at very high yield.

A hair care formulation for improving the tensile strength of damage hair is provided, comprising: (a) a dermatogically acceptable vehicle; and (b) a tensile strength improving additive; wherein the tensile strength improving additive comprises: (b1) a (±)-α-tocopherol; and (b2) a carboxy functional organosiloxane compound of formula (I) wherein x is 0 to 25; wherein each R1 is independently selected from an alkylene radical containing 1 to 10 carbon atoms; wherein each R2 is independently selected from the group consisting of an alkyl group of 1 to 18 carbon atoms, an aryl group of 6 to 18 carbon atoms, an acyloxy group of 2 to 18 carbon atoms, and a hydrocarbonoxy-functional group of 1 to 18 carbon atoms.

The antioxidant activity of alpha-tocopherol polyethylene glycol 1000 succinate (TPGS) and of alpha-tocopherol succinate (TS) has been examined in isolated hepatocytes and microsomal fractions from rat liver. Both TPGS and TS require esterase activity to yield free alpha-tocopherol and, hence, antioxidant activity. TPGS and TS consistently exerted a more effective antioxidant protection than an equivalent amount of directly-added free alpha-tocopherol. The low antioxidant efficiency of directly added free alpha-tocopherol in such water-based experimental systems as used here seems to be due to its extreme hydrophobicity. TPGS, on the other hand, is an extremely hydrophilic compound which is being examined as a useful source of alpha-tocopherol in certain clinical situations and is here shown to be a convenient and effective source for experimental studies into lipid peroxidation and antioxidant mechanisms.

To provide an oral composition containing dl-α-tocopheryl 2-L-ascorbyl phosphate diester alkali metal salt and cetylpyridinium chloride, with reduced photodegradation of the dl-α-tocopheryl 2-L-ascorbyl phosphate diester alkali metal salt.SOLUTION: An oral composition includes dl-α-tocopheryl 2-L-ascorbyl phosphate diester alkali metal salt, cetylpyridinium chloride, and at least one antioxidant selected from the group consisting of ascorbic acid, ascorbic acid derivatives, erythorbic acid, erythorbic acid derivatives, phenolic antioxidants, and salts thereof.SELECTED DRAWING: None

The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.

This application provides a vanadium-based catalyst and its application. The catalyst includes a main catalyst, a co-catalyst, and a porous support. The main catalyst and the co-catalyst are dispersed on the porous support. The main catalyst includes vanadium and optionally molybdenum, and the co-catalyst includes fullerene. Using this vanadium-based catalyst to catalyze the methylation reaction of mixed tocopherols to produce D-α-tocopherol can effectively improve the yield and content of D-α-tocopherol.

The invention discloses an immunogenic composition containing gE nanoparticles as well as a preparation method and application thereof, and relates to the technical field of biomedicine, the immunogenic composition comprises self-assembled gE nanoparticles and an oil-in-water emulsion adjuvant, and a self-assembled gE nanoparticle antigen comprises gE, a connecting peptide SGS and a gI polypeptide sequence containing Th epitopes; the oil-in-water type emulsion adjuvant is prepared from squalene, Tween 80, DL-alpha-tocopherol and / or Span 85. The immunogenic composition provided by the invention can be applied to vaccines for preventing varicella and / or herpes zoster and / or postherpetic neuralgia, so that the aims of improving the immunogenicity of the gE antigen and reducing side effects of the vaccines are fulfilled.

The invention belongs to the technical field of cosmetics, and provides a composition with a synergistic anti-wrinkle effect, application of the composition and cosmetics. The composition provided by the invention comprises tocopherol retinoate and nicotinamide adenine dinucleotide, and the mass part ratio of the tocopherol retinoate to the nicotinamide adenine dinucleotide is 1: (0.02-10). In the composition provided by the invention, the tocopherol retinoate and the nicotinamide adenine dinucleotide have a synergistic anti-wrinkle effect, and the effect of the composition is obviously greater than the sum of the effects of the tocopherol retinoate and the nicotinamide adenine dinucleotide which are independently used in the aspect of promoting the synthesis of the fibroblast collagen I. When the composition with the synergistic anti-wrinkle effect provided by the invention is applied to preparation of cosmetics, the use amount of tocopherol retinoate can be reduced, so that the obvious anti-wrinkle and anti-aging effects are obtained while the irritation is reduced.

The invention relates to a rice grading processing and food preservation technology, and discloses a stabilization processing method for rice aleurone layer component powder. The method sequentially comprises the following steps: adding 30-40% of water, and carrying out colloid milling to 70-100 meshes; filling the materials into a pressure-resistant bag, wherein the bag volume is 50-80% of the bag volume, and sealing after air is exhausted; water is used as a pressure transmitting medium, and ultrahigh pressure treatment is conducted for 100-300 s under the pressure of 500-650 MPa; plate type thin film drying is carried out, the coating thickness is 0.8-1.2 mm, the temperature is 120 + / -5 DEG C, the time is 30 + / -5 s, and the thickness is 0.8-1.2 m.s <-1 >; and cooling, crushing and sieving to obtain powder. The residual lipase activity of the obtained product is less than or equal to 8%, the retention rate of alpha-tocopherol is greater than or equal to 85%, the retention rate of oryzanol is greater than or equal to 88%, and the acid value is less than or equal to 40mgKOH / 100g after the product is stored for 12 months at The method is short in thermal history, quantifiable in parameter and suitable for industrial amplification.

The application discloses a SNP marker related to wheat kernel alpha-tocopherol content and application thereof. The application provides application of a substance for detecting a SNP site Ta-6A-SNP haplotype in a wheat genome in any one of the following: A1) identifying or assisting in identifying wheat kernel alpha-tocopherol content; A2) screening or assisting in screening wheat with high alpha-tocopherol content in kernels; A3) breeding wheat with high alpha-tocopherol content in kernels; A4) wheat genetic breeding. The application finds a SNP site Ta-6A-SNP on a 6A chromosome of wheat, and develops a molecular marker according to the SNP, which is a KASP marker, has good repeatability, low cost, is beneficial to screening wheat varieties with high alpha-tocopherol content, and has important significance for cultivating new wheat varieties with high alpha-tocopherol content.

The application belongs to the technical field of functional food additives, and relates to a D-alpha-tocopherol and gamma-aminobutyric acid co-crystal as well as a preparation method and application thereof. The co-crystal is prepared from D-alpha-tocopherol and gamma-aminobutyric acid through a co-crystallization technology, has a clear crystal structure, and has characteristic peaks in an X-ray diffraction pattern and a unique melting point in a differential scanning calorimetry pattern. The co-crystal can convert oil-like D-alpha-tocopherol into a solid form with good powder property, significantly improve storage stability and oil loading, and has no bad odor, and is easy to be accepted by consumers. The application further provides a co-crystal composition containing acceptable adjuvants, the composition has the same crystal type characteristics as the co-crystal, and further expands application adaptability. The preparation method adopts steps of solvent mixing, heating reaction, low-temperature crystallization, centrifugal drying and the like, is mild in condition, simple in process, and suitable for industrial production.

The invention provides a vancomycin hydrochloride-containing pharmaceutical composition and a preparation method thereof, the pharmaceutical composition is prepared from vancomycin hydrochloride, PEG6000 and DL-alpha-tocopherol, nitrogen is continuously introduced in the preparation process of the pharmaceutical composition, the whole pharmaceutical composition has simple auxiliary materials and only two auxiliary materials, and the prepared pharmaceutical composition has low content of related substances and is suitable for clinical application. The vancomycin hydrochloride hard capsule is simple in preparation method, high in stability and low in cost, DL-alpha-tocopherol is adopted as an auxiliary material, the prepared vancomycin hydrochloride hard capsule reduces degradation and oxidation of vancomycin hydrochloride, the problem that vancomycin hydrochloride is poor in stability is solved, and the whole preparation method is simple, convenient to operate and suitable for industrial large-scale production.

The invention relates to the technical field of organic synthesis, in particular to a preparation method of tocopheryl glycoside. According to the method, tocopherol monomers and acetylated glycosyl donors are used as raw materials, and stereoselective glycosylation coupling is performed under the action of scandium trifluoromethanesulfonate and / or ytterbium trifluoromethanesulfonate, so that tocopherol glycoside can be obtained with high yield and high stereoselectivity. The method has the advantages of high utilization rate of tocopherol, mild reaction conditions, high product purity and safe reaction and post-treatment steps, and is suitable for large-scale production.

A method for determining a combined amount of β-tocopherol and γ-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the β-tocopherol and γ-tocopherol detectable by mass spectrometry; and determining the amount of one or more of said ions by tandem mass spectrometry, wherein tandem mass spectrometry comprises fragmenting β-tocopherol and γ-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions comprising a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of β-tocopherol and γ-tocopherol in the sample.

The present invention relates to a composition for topical application comprising a polyaphron dispersion, the polyaphron dispersion comprising a continuous aqueous phase and at least one discontinuous oil phase,wherein the polyaphron dispersion comprises calcipotriol, betamethasone dipropionate, alpha-tocopherol and butylated hydroxyanisole, andwherein the composition has a pH of 7.75±0.5.

The invention discloses a stabilizer for fuel oil containing ethylene tar and a preparation process of the stabilizer, and belongs to the technical field of energy and chemical industry. The stabilizer is composed of 8-20% of a composite antioxidant, 20-25% of a nano-scale dispersant, 5-8% of a metal deactivator, 10-15% of a viscosity modifier and 20-50% of a solvent, the composite antioxidant is compounded by alkylated diphenylamine and D-tocopherol according to a ratio of 3: 1, the nano-scale dispersant is prepared by loading polyisobutylene succinimide on a silane coupling agent modified nano-silica carrier, and the viscosity modifier is a silane coupling agent modified nano-silica carrier. The metal passivator is selected from six specific benzotriazole derivatives. According to the preparation method, the synergistic interaction of the components is realized through the processes of nano-carrier surface modification, dispersing agent in-situ loading, antioxidant system compounding, high-pressure homogenization treatment and the like. Through innovative formula design and process optimization, the problems of storage deterioration, metal catalytic deterioration and viscosity regulation of ethylene tar fuel oil are solved, and the method has important industrial application value.

Anti-inflammatory topical compositions are disclosed in which niacinamide and polylysine dendrimer synergistically reduce the release of inflammatory markers (e.g., IL-8) from skin cells. Also disclosed are anti-inflammatory topical compositions in which polylysine dendrimer and various plant extracts reduce the release of inflammatory markers (e.g., IL-8) from skin cells. The pro-oxidative activity of polylysine dendrimer may be reduced by including an antioxidant (e.g., tocopherol and / or tocopheryl acetate) to an anti-inflammatory topical composition. Anti-inflammatory topical compositions comprising polylysine dendrimer and niacinamide and / or plant extracts (e.g., aloe vera extract, edelweiss extract, scuatline, etc.) may be used for treating inflammatory skin conditions (e.g., acne) by reducing the release of inflammatory markers (e.g., IL-8) from skin cells.

The invention relates to a rapid setting liquid lung sealant that forms a highly adherent and elastic hydrogel. Provided are lung sealants comprising two high molecular weight (20 kDa) multi-arm PEG compositions wherein the first PEG composition includes an alkaline buffer and the second PEG composition includes a mildly acidic buffer for optimized set up time and extended working time. In some embodiments, the PEGs further comprise a radioprotectant such as tocopherol. In some embodiments, a colorant is added to one or both PEGs of the lung sealant to improve visualization of the lung sealant against human lung tissue.

The invention relates to a polyethylene glycol lipid molecule containing a tocopherol structure, lipid nanoparticles containing the polyethylene glycol lipid molecule and application of the polyethylene glycol lipid molecule. Specifically, the invention provides a polyethylene glycol lipid molecule containing tocopherol and a derivative structure thereof as shown in a formula (1), a lipid nanoparticle containing the polyethylene glycol lipid molecule, and a preparation method and application of the polyethylene glycol lipid molecule. Compared with a polyethylene glycol lipid molecule conventionally used in the field, the lipid nanoparticles prepared from the polyethylene glycol lipid molecule shown in the formula (1) can significantly improve the delivery efficiency and expression of nucleic acid. # imgabs0 #

A method for spectrophotometric detection of γ-tocopherol in a sample, comprising mixing the sample with a reagent composition in a solvent to form a mixture; incubating the mixture; measuring absorbance of the mixture; and correlating the measured absorbance to γ-tocopherol concentration in the sample.

A method for determining a combined amount of β-tocopherol and γ-tocopherol in a sample by tandem mass spectrometry includes subjecting the sample to ionization under conditions suitable to produce one or more ions from the β-tocopherol and γ-tocopherol detectable by mass spectrometry; and determining the amount of one or more of the ions by tandem mass spectrometry. Tandem mass spectrometry methods of this disclosure involve fragmenting β-tocopherol and γ-tocopherol ions having a mass to charge ratio of about 416.35±0.80 into one or more fragment ions including a fragment ion having a mass to charge ratio of about 151.00±0.80, wherein the amount of the one or more ions determined is related to the combined amount of β-tocopherol and γ-tocopherol in the sample.

The present application relates to the technical field of tocopherol-containing polycarboxylate surfactant, and discloses a tocopherol-containing polycarboxylate surfactant and application thereof in pesticides, wherein the tocopherol-containing polycarboxylate surfactant is prepared from trans-1,4-dichloro-2-butene, diethanolamine, phosphorus pentoxide and the like as raw materials through substitution reaction and esterification reaction to obtain an olefin-containing tetraphosphoric acid intermediate; DL-alpha-tocopherol, maleic anhydride, polyethylene glycol and the like are used as raw materials to obtain tocopherol-modified polyethylene glycol through two-step reaction; and the olefin group contained in the tocopherol-modified polyethylene glycol is used to copolymerize with acrylic acid, the olefin-containing tetraphosphoric acid intermediate and the like to obtain the tocopherol-containing polycarboxylate surfactant. The tocopherol-containing polycarboxylate surfactant prepared by the present application can be applied to pesticides to improve the suspension effect and heat storage stability of the pesticide water suspension agent.

The invention discloses a colchicine tablet with high stability, which comprises colchicine, a filler, an adhesive, a disintegrating agent, an antioxidant, an opacifying agent, a flow aid and a lubricant, and the antioxidant is alpha-tocopherol; the invention also provides a preparation method of the colchicine tablet. The colchicine and the antioxidant alpha-tocopherol are dissolved in ethanol and then are granulated, so that the colchicine is prevented from being decomposed in water, the increase of related substances can be effectively reduced, and the stability of the colchicine tablet is improved. The compressibility and hardness of the colchicine tablet can be obviously improved by adding the microcrystalline cellulose into the prescription. In addition, a small amount of opacifying agent titanium dioxide is added into the prescription, so that the storage stability of the colchicine tablet can be obviously improved.

The present invention discloses an absorbable bone wax and its preparation method and application. The absorbable bone wax, by mass fraction, comprises the following raw materials: 5-10 parts of hydroxyethyl silane, 10-30 parts of polyethylene glycol α-tocopherol succinate, 10-50 parts of multi-carboxyl substituted chitosan, and 1-5 parts of strontium salt. The absorbable bone wax of the present invention has a dense structure, excellent viscosity, and excellent ductility and stability. It is used for preparing or directly serving as a bone hemostasis, bone defect or bone transplantation repair material, and has various functions such as promoting rapid mechanical hemostasis of bone cross-sections and promoting bone repair and regeneration. In addition, the absorbable bone wax of the present invention has controllable degradation and can meet the requirements of different clinical scenarios.

The application discloses an EPA liposome and a preparation method and application thereof, and particularly relates to the technical field of cosmetics. The EPA liposome is prepared through self-assembly of liposomes by using the following raw materials in parts by mass: microalgae oil EPA 1-4 parts, epicatechin-3-gallate 1-2 parts, alpha-tocopherol 0.2-1 part, ginsenoside Rg3 0.02-0.1 part, lipids 2-10 parts, emulsifier 1-10 parts, and water is supplemented to 100 parts. The EPA liposome realizes the stable effect of EPA in a composite system such as a cosmetic skin care product, enhances the in-situ antioxidant and protective functions of EPA and slows down the autoxidation of EPA, improves the bioavailability and enhances the anti-aging effect through the synergy of the contained efficacy substances and the design of the nano-liposome.

The application relates to an application of a geranylgeranyl pyrophosphate reductase in preparation of tocopherol, wherein a nucleotide sequence coding the geranylgeranyl pyrophosphate reductase is shown as SEQ ID No. 11, and the application comprises the following steps: under the assistance of coenzyme iron-oxidation-reduction protein and iron-oxygen-reduction protein-NADP+ reductase, the geranylgeranyl pyrophosphate reductase catalyzes the reduction of delta-tocotrienol to generate delta-tocopherol. The geranylgeranyl pyrophosphate reductase has the function of reducing the unsaturated isoprene side chain of tocotrienol, can catalyze the reduction of tocotrienol to generate tocopherol, does not need to depend on the geranyl pyrophosphate precursor in the existing tocopherol biosynthesis pathway, significantly improves the tocopherol synthesis efficiency, and provides a new strategy for the biosynthesis of tocopherol and other tocopherols.

This invention relates to the field of vaccine adjuvant technology, and discloses an oil-in-water adjuvant containing squalene and α-tocopherol, its preparation method, and its application. The preparation method includes the following steps: mixing squalene, α-tocopherol, and poloxamer to obtain an oil phase mixture; subjecting the oil phase mixture to high-speed shearing with an aqueous phase to obtain a pre-emulsion; and subjecting the pre-emulsion to high-pressure homogenization to obtain the oil-in-water adjuvant. This invention, through the synergistic effect of α-tocopherol and poloxamer, combined with a specific preparation process, solves the problems of poor stability and uneven particle size distribution in existing adjuvants. The adjuvant prepared by this invention exhibits excellent long-term physicochemical stability, with a Z-average particle size in the range of 100-300 nm and a polydispersity index (PDI) of less than 0.25, demonstrating good immunostimulant carrying capacity and immune enhancement effect.

The invention relates to the technical field of biological and pharmaceutical preparations, and discloses an AS04 adjuvant composition for a vaccine as well as a preparation method and application of the AS04 adjuvant composition. The preparation method comprises the following steps: preparing 3-O-deacyl-4 '-monophosphoryl lipid A A polymer stabilizer; squalene; the preparation method comprises the following steps: S1, carrying out mixed adsorption on 3-O-deacyl-4'monophosphoryl lipid A and aluminum hydroxide, so as to prepare an adjuvant base core; s2, squalene and alpha-tocopherol are mixed and dissolved, and an oil phase premix is prepared; s3, dropwise adding the oil phase premix into the adjuvant-based core suspension under a low shearing force; s4, adding a polymer stabilizer solution into the mixture to carry out polymer coating; and S5, freeze-drying the final mixture. By sequentially constructing a multi-layer protection structure, the AS04 adjuvant is endowed with excellent freeze-drying stability, rapid redissolving performance and antigen activity protection effect.

A solvent-free preparation method for an α-tocopherol and betaine complex, which method comprises mixing oily α-tocopherol with betaine which has been crushed to have a specific particle size range by means of high-speed dispersion, and then performing solidification under a heating condition to form the α-tocopherol and betaine complex. The α-tocopherol and betaine complex obtained by means of the method has a higher powder density. Compared with a traditional solvent crystallization method, the method has a high yield and a simple process, is green and environmentally friendly, and has a large cost advantage.

This invention discloses a strain of *Enterobacter cloacae* EC11 and its applications, belonging to the field of microbial technology. The strain is classified as *Enterobacter cloacae* EC11, with the accession number CCTCC NO:M 2025610. This strain exhibits a hydrolysis zone HC value of 3 on tributyrate agar plates and a lipase activity of 145.28 U / mL. This invention also provides the application of this strain and its produced lipase in the catalytic hydrolysis of tocopherol succinate to prepare tocopherol. The crude enzyme solution obtained by fermenting the lipase strain EC11 was added to a reaction system containing tocopherol succinate for hydrolysis. After 9 hours of reaction, the tocopherol content was increased by 725% compared to the control group. The strain and method provided by this invention have high catalytic efficiency, mild reaction conditions, and are environmentally friendly, making them suitable for the green industrial production of tocopherol.