The invention discloses a vancomycin hydrochloride medicine composition and a method for preparing the same. The vancomycin hydrochloride medicine composition comprises 10-60% of vancomycin hydrochloride, 30-90% of matrixes and 0-10% of lubricants, and preferably comprises 30-40% of vancomycin hydrochloride, 50-70% of matrixes and 2-8% of lubricants. The matrixes are one or two types of PEG (polyethylene glycol) 1000-6000, stearic acid and poloxamer 188, and the lubricants are one or two types of micro-powder silica gel, talc powder, sodium stearyl fumarate, sodium dodecyl sulfate and magnesium stearate. The vancomycin hydrochloride medicine composition can be in one of dosage forms of soft capsules, hard capsules and tablets. The vancomycin hydrochloride medicine composition and the method have the advantages that components in the vancomycin hydrochloride medicine composition are easily matched with one another, and medicines are high in stability; hot melting technologies are adopted in the method for preparing the vancomycin hydrochloride medicine composition, processes for producing the vancomycin hydrochloride medicine composition are simple, can be implemented conveniently and quickly, are stable and can be scaled up advantageously, and service dosage forms of the vancomycin hydrochloride can be broadened.