Metal implant with antibacterial and osteosynthesis-promoting functions and preparation method thereof
An implant and osseointegration technology, applied in the field of medical devices, can solve problems such as increasing the probability of bacterial infection, achieve excellent bactericidal performance, promote osseointegration, and maintain the effect of killing ability
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[0053] The preparation method provided by the present invention comprises the following steps:
[0054] In order to solve the above-mentioned technical problems, the present invention provides a preparation method of a metal implant with antibacterial and osseointegration promotion functions, comprising the following steps:
[0055] (1) Preparation of metal implants;
[0056] (2) using the micro-arc oxidation method to perform surface treatment on the metal implant, and covering the surface of the metal implant with a micro-arc oxidation coating containing calcium and phosphorus elements;
[0057] (3) immersing the metal implant treated in step (2) in a dopamine hydrochloride solution of 2-5 mg / mL, and oscillating at a constant temperature of 30-45° C. for 20-24 hours;
[0058] (4) Use deionized water or distilled water as a solvent, add heparin sodium to dissolve, and prepare a heparin sodium solution with a concentration of 1 to 5 mg / mL, then use the heparin sodium solution...
Embodiment 1
[0087] (1) Metal implants with interconnected pores were prepared using 3D printing technology.
[0088] Individually adapted porous Ti-6Al-4V implants were printed using the EBM S12 electron beam melting equipment produced by the Swedish ARCAM company, with a pore diameter of 640 μm, a pillar diameter of 400 μm, and a diamond lattice pore structure.
[0089] (2) Utilize micro-arc oxidation method to carry out surface treatment to described porous Ti-6Al-4V implant, be covered with the micro-arc oxidation coating of 2.1 μm on the outer surface of this implant, the inner surface is covered with 1.1 μm Micro-arc oxidation coating.
[0090] (21) Use deionized water to prepare an alkaline electrolyte containing calcium acetate 0.065mol / L, sodium dihydrogen phosphate 0.03mol / L, EDTA-2Na0.04mol / L, and sodium hydroxide 0.5mol / L;
[0091] (22) With the porous Ti-6Al-4V implant prepared in step (1) as the anode and the stainless steel as the cathode, a magnetic stirrer is used to stir...
Embodiment 2
[0165] (1) The EBM S12 electron beam melting equipment was used to print individualized porous titanium implants with a pore diameter of 600 μm, a pillar diameter of 500 μm, and a dodecahedral pore structure.
[0166] (2) The porous titanium implant is surface treated by micro-arc oxidation method. The outer surface of the implant is covered with a 1.5 μm micro-arc oxidation coating, and the inner surface is covered with a 0.8 μm micro-arc oxidation coating. Floor.
[0167] (21) Use deionized water or prepare an alkaline electrolyte containing 0.01mol / L calcium acetate, 0.01mol / L sodium dihydrogen phosphate, 0.02mol / L EDTA-2Na, and 0.25mol / L sodium hydroxide;
[0168] (22) The porous titanium implant prepared in step (1) was used as the anode, and the stainless steel was used as the cathode, and the alkaline electrolyte was stirred with a magnetic stirrer at a stirring speed of 60 times / min; a DC pulse power supply was used for micro-arc oxidation. Set the voltage to 250V, th...
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