Metal implant with antibacterial and osteosynthesis-promoting functions and preparation method thereof

An implant and osseointegration technology, applied in the field of medical devices, can solve problems such as increasing the probability of bacterial infection, achieve excellent bactericidal performance, promote osseointegration, and maintain the effect of killing ability

Active Publication Date: 2018-02-02
刘忠军 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at the problem that metal implants in the prior art also increase the probability of bacterial infection while promoting osseointegration, the present invention provides a metal implant that can promote osseointegration and has excellent antibacterial effect and its preparation method

Method used

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  • Metal implant with antibacterial and osteosynthesis-promoting functions and preparation method thereof
  • Metal implant with antibacterial and osteosynthesis-promoting functions and preparation method thereof
  • Metal implant with antibacterial and osteosynthesis-promoting functions and preparation method thereof

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preparation example Construction

[0053] The preparation method provided by the present invention comprises the following steps:

[0054] In order to solve the above-mentioned technical problems, the present invention provides a preparation method of a metal implant with antibacterial and osseointegration promotion functions, comprising the following steps:

[0055] (1) Preparation of metal implants;

[0056] (2) using the micro-arc oxidation method to perform surface treatment on the metal implant, and covering the surface of the metal implant with a micro-arc oxidation coating containing calcium and phosphorus elements;

[0057] (3) immersing the metal implant treated in step (2) in a dopamine hydrochloride solution of 2-5 mg / mL, and oscillating at a constant temperature of 30-45° C. for 20-24 hours;

[0058] (4) Use deionized water or distilled water as a solvent, add heparin sodium to dissolve, and prepare a heparin sodium solution with a concentration of 1 to 5 mg / mL, then use the heparin sodium solution...

Embodiment 1

[0087] (1) Metal implants with interconnected pores were prepared using 3D printing technology.

[0088] Individually adapted porous Ti-6Al-4V implants were printed using the EBM S12 electron beam melting equipment produced by the Swedish ARCAM company, with a pore diameter of 640 μm, a pillar diameter of 400 μm, and a diamond lattice pore structure.

[0089] (2) Utilize micro-arc oxidation method to carry out surface treatment to described porous Ti-6Al-4V implant, be covered with the micro-arc oxidation coating of 2.1 μm on the outer surface of this implant, the inner surface is covered with 1.1 μm Micro-arc oxidation coating.

[0090] (21) Use deionized water to prepare an alkaline electrolyte containing calcium acetate 0.065mol / L, sodium dihydrogen phosphate 0.03mol / L, EDTA-2Na0.04mol / L, and sodium hydroxide 0.5mol / L;

[0091] (22) With the porous Ti-6Al-4V implant prepared in step (1) as the anode and the stainless steel as the cathode, a magnetic stirrer is used to stir...

Embodiment 2

[0165] (1) The EBM S12 electron beam melting equipment was used to print individualized porous titanium implants with a pore diameter of 600 μm, a pillar diameter of 500 μm, and a dodecahedral pore structure.

[0166] (2) The porous titanium implant is surface treated by micro-arc oxidation method. The outer surface of the implant is covered with a 1.5 μm micro-arc oxidation coating, and the inner surface is covered with a 0.8 μm micro-arc oxidation coating. Floor.

[0167] (21) Use deionized water or prepare an alkaline electrolyte containing 0.01mol / L calcium acetate, 0.01mol / L sodium dihydrogen phosphate, 0.02mol / L EDTA-2Na, and 0.25mol / L sodium hydroxide;

[0168] (22) The porous titanium implant prepared in step (1) was used as the anode, and the stainless steel was used as the cathode, and the alkaline electrolyte was stirred with a magnetic stirrer at a stirring speed of 60 times / min; a DC pulse power supply was used for micro-arc oxidation. Set the voltage to 250V, th...

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Abstract

The present invention relates to a metal implant having antibacterial and osteosynthesis-promoting functions and a preparation method thereof, and the method comprises (1) preparing a metal implant, (2) subjecting the metal implant to surface treatment by using a micro-arc oxidation method, and covering the surface of the metal implant with a micro-arc oxidation coating containing calcium and phosphorus elements; (3) immersing the metal implant treated in the step (2) into a dopamine hydrochloride solution with the concentration of 2 to 5 mg / mL, and shaking at constant temperature of 30 to 45DEG C for 20 to 24 hours; (4) using deionized water or distilled water as a solvent, adding heparin sodium to prepare a heparin sodium solution with the concentration of 1 to 5 mg / mL, using the heparin sodium solution as a solvent, and adding vancomycin hydrochloride for preparing a vancomycin hydrochloride solution with a concentration of 50-200 mug / mL; immersing the metal implant treated in thestep (3) in the vancomycin hydrochloride solution, and shaking at constant temperature of 30 to 45 DEG C for 3 to 12 hours to obtain the metal implant.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to a metal implant with antibacterial and osseointegration promotion functions and a preparation method thereof. Background technique [0002] Metal implants are widely used clinically, but metal implants exhibit significant biological inertness. At present, the use of surface modification technology to improve the surface activity of metal implants is an effective way to further improve its application effect. [0003] At present, the prior art discloses a method for preparing a calcium-phosphorus coating on the porous surface of a metal implant, which can improve its osseointegration performance. However, the surface of biomaterials that can promote the adhesion and growth of bone cells is also suitable for bacterial colonization, especially 3D printed porous metal orthopedic implants, although they have the characteristics of strong osseointegration and can be individually adapted...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/50A61L27/54A61L27/32A61L27/34A61L27/06A61L27/04A61L27/56C25D11/26C25D11/30
CPCA61L27/047A61L27/06A61L27/32A61L27/34A61L27/50A61L27/54A61L27/56A61L2300/232A61L2300/406A61L2300/606A61L2400/18A61L2430/02C25D11/026C25D11/26C25D11/30C08L5/10C08L79/02
Inventor 刘忠军张腾
Owner 刘忠军
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