Hollow SiO2 wrapped hollow Au cage nanometer bell and preparing method and application thereof

A hollow and hollow technology, applied in the direction of nanotechnology, nanotechnology, nanotechnology for materials and surface science, etc., can solve the problem of low drug loading and achieve the effect of improving biocompatibility

Inactive Publication Date: 2016-02-03
SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But solid SiO 2 May shield Raman signa

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  • Hollow SiO2 wrapped hollow Au cage nanometer bell and preparing method and application thereof
  • Hollow SiO2 wrapped hollow Au cage nanometer bell and preparing method and application thereof
  • Hollow SiO2 wrapped hollow Au cage nanometer bell and preparing method and application thereof

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[0052] In a more specific embodiment, the preparation method may include: firstly using sodium hydrosulfide mediated polyol method to prepare Ag cubes, and then using HAuCl to prepare Ag cubes. 4 The Ag cube is transformed into a hollow Au cage in a solution at 100 °C. Preferably, Raman signal molecules can also be modified on the surface of the hollow Au cage, and SiO can be coated at the same time or later. 2 layer, and then selectively etched the SiO 2 layer into hollow SiO 2 , preferably, also in SiO 2 Surface modification of biocompatible molecules such as bioactive peptides.

[0053] Further, in a more specific embodiment, a method for preparing the hollow SiO 2 The method of encapsulating the hollow Au cage nano-rattle can include the following steps:

[0054] (1) Preparation of Ag cubes

[0055] Using the polyol method, ethylene glycol (EG) was heated at 100-200 °C for 1-60 min, and sodium hydrosulfide (NaHS), hydrochloric acid (HCl), polypyrrolidone (PVP) and sil...

Embodiment 1

[0067] (1) Preparation of Ag cubes

[0068] Using the polyol method, 25 mL of ethylene glycol (EG) was heated at 150 °C for 30 min, followed by adding 0.3 mL of 3 mM NaHS solution, 2.5 mL of 3 mM hydrochloric acid, 6.25 mL of 20 mg / mL PVP solution and 2.0 mL of 3 mM hydrochloric acid. CF at a concentration of 282mM in mL 3 The EG solution of COOAg was heated at 150 °C for 1 h, the reaction flask was placed in an ice-water bath to stop the reaction, centrifuged, washed with water, and the prepared Ag cubes were dispersed in 10 mL of deionized water. For the morphology, particle size distribution, UV-Vis spectrum and SERS spectrum of the Ag cubes, please refer to Figure 1a , Figure 2a , image 3 (line a), Figure 4 (line a).

[0069] (2) Preparation of Au cages

[0070] Using the electro-displacement reaction method, 1 mL of the Ag cube dispersion prepared in step (1) was added to 50 mL of an aqueous solution containing 1 mg / mL PVP, heated to 100 °C, and HAuCl with a con...

Embodiment 2

[0078] (1) Preparation of Ag cubes

[0079] Using the polyol method, 25 mL of ethylene glycol (EG) was heated at 160 °C for 30 min, and 0.3 mL of NaHS solution with a concentration of 6 mM, 2.5 mL of hydrochloric acid with a concentration of 6 mM, 6.25 mL of PVP solution with a concentration of 20 mg / mL and 2.0 mL of The EG solution of CF3COOAg with a concentration of 282mM was heated at 160°C for 30min, the reaction flask was placed in an ice-water bath to stop the reaction, centrifuged, washed with water, and the prepared Ag cubes were dispersed in 10mL of deionized water.

[0080] (2) Preparation of hollow Au cages

[0081] Using the electro-displacement reaction method, 1 mL of the Ag cube dispersion prepared in step (1) was added to 50 mL of an aqueous solution containing 2 mg / mL PVP, heated to 70 °C, and the concentration of HAuCl was 0.4 mM. 4 The solution was added dropwise to the reaction solution at a rate of 0.75mL / min, the dropwise addition was stopped at 30min, t...

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Abstract

The invention discloses a hollow SiO2 wrapped hollow Au cage nanometer bell and a preparing method and application thereof. The nanometer bell comprises a hollow SiO2 micro ball and a hollow Au cage movably arranged in an inner cavity of the hollow SiO2 micro ball. The preparing method of the nanometer bell comprises the steps that an Ag cuboid and the like are utilized as a template, the hollow Au cage is manufactured, Raman signal molecule modification and SiO2 shell layer wrapping are carried out on the surface of the Au cage, and an SiO2 wrapped hollow Au cage core-shell structure nanometer particle is formed; and in addition, the selective surface etching is carried out on the core-shell structure nanometer particle, and the nanometer bell is prepared. The nanometer bell has high stability and biocompatibility and can serve as a good medicine carrier, the absorption in a near-infrared area can be adjusted, the light energy of near-infrared lasers is converted into heat energy, meanwhile, the Raman signal can be enhanced, and huge application prospects are achieved in the medical fields such as medicine carrying, photo-thermal treatment and Raman imaging.

Description

technical field [0001] The invention relates to a rattle-type nano material and a preparation method thereof, in particular to a hollow SiO 2 The invention discloses a method for preparing a hollow Au cage nano rattle, which belongs to the field of inorganic materials. technical background [0002] Gold nanomaterials, due to their unique chemical and physical properties, have broad application prospects in the fields of electronics, optics, catalysis and biomedicine. In recent years, a variety of gold nanostructures including gold nanorods, gold nanoshells and gold nanocages have attracted widespread attention in the field of biomedicine (N.Li, P.X.Zhao, D.Astruc, Angew. Chem. Int. Ed. 2014, 53, 1756). [0003] The surface of these gold nanostructures has a strong electromagnetic field, which can be used as a surface-enhanced Raman substrate to enhance the Raman molecules adsorbed on the surface, and can be used as a Raman probe for biological detection and imaging (M.Ryce...

Claims

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Application Information

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IPC IPC(8): B22F1/02B22F9/24B82Y40/00B82Y30/00
Inventor 王强斌胡峰
Owner SUZHOU INST OF NANO TECH & NANO BIONICS CHINESE ACEDEMY OF SCI
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