Lipid carrier of curcumin in nano structure and preparation method of lipid carrier

A nano-structured lipid, curcumin technology, applied in oil/fat/wax inactive ingredients, digestive system, metabolic diseases, etc.

Active Publication Date: 2014-08-20
CHONGQING MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The curcumin nanostructured lipid carrier prepared by the present invention greatly overcomes the shortcomings of curcumin, such as insoluble in water, low oral bioava

Method used

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  • Lipid carrier of curcumin in nano structure and preparation method of lipid carrier
  • Lipid carrier of curcumin in nano structure and preparation method of lipid carrier
  • Lipid carrier of curcumin in nano structure and preparation method of lipid carrier

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] The composition ratio by weight of each component contained in the formula is: 0.1 part of curcumin, 6 parts of polyethylene glycol-400, 9 parts of polyoxyethylene castor oil, 28 parts of ethyl oleate, 5 parts of aqueous phase (1), 0.5 parts of tripalmitin, 1 part of phospholipid, 2 parts of glyceryl monostearate, 1.5 parts of Tween-80, 70 parts of water phase (2).

[0016] The preparation method comprises the following steps: (1) preparation of curcumin nanoemulsion: take curcumin, ethyl oleate, polyethylene glycol-400 and polyoxyethylene castor oil, after stirring in the dark in a water bath, the water phase (1 ) was slowly added dropwise to the above preparation, and stirred in the dark to obtain curcumin nanoemulsion; (2) preparation of curcumin nanostructured lipid carrier: weigh glyceryl monostearate, phospholipid, glyceryl tripalmitate, Place in a round bottom flask, add absolute ethanol or dichloromethane, and spin dry in a water bath in the dark, so that a unif...

Embodiment 2

[0018] The composition ratio by weight of each component contained in the formula is: 0.2 parts of curcumin, 8 parts of polyethylene glycol-400, 10 parts of polyoxyethylene castor oil, 25 parts of ethyl oleate, 2 parts of water phase (1), 1 part of tripalmitin, 2 parts of phospholipid, 2.5 parts of glyceryl monostearate, 1.5 parts of Tween-80, 120 parts of water phase (2).

[0019] The preparation method is basically the same as in Example 1.

Embodiment 3

[0021] The composition ratio by weight of each component contained in the formula is: 0.6 parts of curcumin, 7 parts of polyethylene glycol-400, 8 parts of polyoxyethylene castor oil, 27 parts of ethyl oleate, 3 parts of water phase (1), 1.5 parts of tripalmitin, 3 parts of phospholipids, 4 parts of glyceryl monostearate, 3.0 parts of Tween-80, and 70 parts of aqueous phase (2).

[0022] The preparation method is basically the same as in Example 1.

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Abstract

The invention belongs to the field of medicine preparations and relates to a formula of a lipid carrier of curcumin in a nano structure and a preparation method of the lipid carrier. The lipid carrier of curcumin in the nano structure extremely overcomes the deficiencies that curcumin is difficult to be dissolved in water, low in oral bioavailability, fast in metabolism and the like, provides a novel selectable transfer system for curcumin and has important meaning.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and relates to a curcumin nanostructured lipid carrier and a preparation method thereof. Background technique [0002] Curcumin is a phenolic compound obtained from the rhizome of the ginger plant turmeric. It is an active ingredient of the traditional Chinese medicine turmeric. Modern pharmacological studies have shown that curcumin has anti-inflammatory, anti-oxidation, anti-tumor, choleretic, blood fat-lowering, and antibacterial properties. and other pharmacological effects. Due to its poor solubility in water, free curcumin is not easy to absorb in the body, has low bioavailability, fast metabolism, and short half-life, which limits its wide application in clinical practice. Nanostructured lipid carrier is the second generation of solid lipid nanoparticles developed on the basis of solid lipid nanoparticles, and is a new type of nanostructured drug delivery system. In the present...

Claims

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Application Information

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IPC IPC(8): A61K9/51A61K31/12A61K47/44A61P29/00A61P39/06A61P35/00A61P1/16A61P3/06A61P31/04
Inventor 张景勍晏子俊孙立力万坤李万玉胡雪原
Owner CHONGQING MEDICAL UNIVERSITY
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