Preparation method of biodegradable polymer-encapsulated water-soluble molecular microspheres
A high-molecular, water-soluble technology, applied in the direction of powder transportation, block transportation, etc., can solve the problem of low encapsulation rate of water-soluble molecules
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Embodiment 1
[0025] Add 0.5 g of polylactic acid-glycolic acid copolymer with a molecular weight of 17800 into 5 mL of dichloromethane and shake to dissolve to obtain a degradable polymer oil solution. Take 500 μl of a prepared 100 mg / mL aqueous solution of ofloxacin (containing 0.1% methylcellulose, g / mL), add 0.1 g of mesoporous silicon with a particle size of 25 nm and shake well to obtain the inner aqueous phase. Add the internal water phase into the degradable polymer oil solution, and disperse at 7200rpm for 10 minutes to obtain colostrum. Dissolve 30 mg of methylcellulose in 50 mL of water (0.06%, g / mL), add colostrum and disperse at 7200 rpm for 10 minutes to obtain double emulsion. Add the double emulsion to 400mL water for precipitation at 35°C for 4h. After the microspheres were obtained by suction filtration, they were dried at 40°C for 10 hours. Compared with the microspheres without mesoporous silicon, the encapsulation efficiency of ofloxacin increased from 25% to 72%.
Embodiment 2
[0027] Add 0.4 gram of polylactic acid with a molecular weight of 23000 into 5 mL of dichloromethane and shake to dissolve to obtain a degradable polymer oil solution. Take 600μl prepared 50mg / mL TGF-β 3 Aqueous solution (containing 1% polyethylene glycol, g / mL), adding 0.1 mg of mesoporous silicon with a particle size of 30 nm and shaking to obtain the inner aqueous phase. Add the internal water phase into the degradable polymer oil solution, and disperse at 9000rpm for 25 minutes to obtain colostrum. Dissolve 300 mg of polyethylene glycol in 30 mL of water (1%, g / mL), add colostrum and disperse at 10,000 rpm for 30 minutes to obtain double emulsion. Add the double emulsion to 400mL water for precipitation at 35°C for 4h. After the microspheres were obtained by suction filtration, they were dried at 40°C for 10 h. TGF-β 3 Encapsulation increased from 15% to 42%.
Embodiment 3
[0029] 0.6 gram of polycaprolactone with a molecular weight of 38000 was added into 4 mL of dichloromethane and shaken to dissolve to obtain a degradable polymer oil solution. Take 400 μl of prepared 10 mg / mL vitamin C aqueous solution, add 50 mg of mesoporous hydroxyapatite with a particle size of 25 nm and shake well to obtain the inner water phase. Add the internal water phase into the degradable polymer oil solution, and disperse at 10,000 rpm for 50 minutes to obtain colostrum. Dissolve 30 mg of methylcellulose in 40 mL of water (0.075%, g / mL), add colostrum and disperse at 12000 rpm for 20 minutes to obtain double emulsion. The double emulsion was added to 400mL of water for precipitation at 35°C for 3h. After the microspheres were obtained by suction filtration, they were dried at 40°C for 10 h. Vitamin C encapsulation increased from 15% to 45%.
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