Repairing essence containing peony seed oil nano-liposome and preparation method thereof

A technology of nano-liposome and peony seed oil is applied in the directions of medical preparations containing active ingredients, preparations for skin care, pharmaceutical formulations, etc. High skin safety and the effect of increasing the transdermal absorption rate

Active Publication Date: 2021-06-15
广州东智盟化妆品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide a repairing essence containing peony seed oil nano liposome and its preparation method, which solves the problem that peony seed oil is not added to water-based skin care products in the prior art

Method used

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  • Repairing essence containing peony seed oil nano-liposome and preparation method thereof
  • Repairing essence containing peony seed oil nano-liposome and preparation method thereof
  • Repairing essence containing peony seed oil nano-liposome and preparation method thereof

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preparation example Construction

[0049] The preparation method of peony seed oil nano liposome of the present invention specifically comprises the following steps:

[0050] (1) In terms of parts by mass, 24 parts of surfactants, 2.4-12 parts of sterols and 2.4-12 parts of peony seed oil are weighed;

[0051] (2) Surfactant and sterol are mixed and stirred to obtain oil phase I, and then cooled to room temperature;

[0052] (3) Add peony seed oil to oil phase I, mix to obtain oil phase II, stir after heating up, and then cool down to room temperature;

[0053] (4) Glycerin and distilled water are mixed, and the water phase is obtained after preheating;

[0054] (5) Add the water phase to the oil phase II, mix and stir, and then incubate to obtain a mixed solution; then homogenize the mixed solution at a speed of 10000-20000r / min for 1-4 minutes to obtain colostrum, and cool down to 0-4 ℃;

[0055] (6) The colostrum is ultrasonically dispersed to obtain the peony seed oil nanoliposome.

[0056] The particle...

Embodiment 1

[0088] A repairing essence containing peony seed oil nano liposome, by mass percentage, comprising the following components:

[0089]

[0090]

[0091] The sum of all components is based on 100 parts, and the preparation method specifically includes the following steps:

[0092] S1. Add 0.2 parts of acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer to 47 parts of water, soak the ammonium acryloyldimethyl taurate / VP copolymer with water, and let it stand for 1 hour. Obtain mixed solution A;

[0093] After uniformly dispersing 0.08 parts of sodium hyaluronate with 3 parts of glycerin, add 47 parts of water, stir and heat until completely dissolved to obtain a mixed solution B; raise the temperature of the mixed solution B to 60°C, add 0.6 parts of p-hydroxyacetophenone and 0.6 part of 1,2-hexanediol, stirred and heated until completely dissolved to obtain mixed solution C;

[0094] S2. Add mixed solution C into mixed solution A, stir and heat to 75°C, cont...

Embodiment 2

[0098] A repairing essence containing peony seed oil nano liposome, by mass percentage, comprising the following components:

[0099]

[0100]

[0101] The sum of all components is based on 100 parts, and the preparation method specifically includes the following steps:

[0102] S1. Add 0.3 parts of acrylic acid (ester) / C10-30 alkanol acrylate crosslinked polymer to 46.8 parts of water, soak the ammonium acryloyldimethyl taurate / VP copolymer with water, and let it stand for 2 hours. Obtain mixed solution A;

[0103] After uniformly dispersing 0.05 parts of sodium hyaluronate with 2 parts of glycerin and 2 parts of 1,3-butanediol, add 47 parts of water, stir and heat until completely dissolved to obtain mixed solution B; heat mixed solution B to 60°C, Add 0.55 parts of p-hydroxyacetophenone and 0.55 parts of 1,2-hexanediol, stir and heat until completely dissolved to obtain mixed solution C;

[0104] S2. Add mixed solution C into mixed solution A, stir and heat to 80°C,...

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Abstract

The invention relates to the technical field of fine chemical engineering, in particular to repairing essence containing peony seed oil nano-liposome and a preparation method thereof. The repairing essence comprises polyhydric alcohol, a thickening agent, p-hydroxyacetophenone, 1,2-hexanediol, sodium hyaluronate and the peony seed oil nano-liposome; and no preservative is added, and a liposome embedding technology is applied to the functional components which are not prone to penetrating through the skin cuticle, so that the transdermal absorption rate of the functional components is increased, and the skin care effect is greatly improved. After the essence containing the peony seed oil nano-liposome is used, the skin cutin barrier is better repaired, the transepidermal water loss rate is reduced, that is, the water retention capacity of the skin is improved, the moisturizing performance of the skin is improved, and the health degree of the skin is improved; the effect of improving skin pigmentation is achieved, and the effect of improving the skin with the color sinking problems such as spots and acne marks is more remarkable; and the collagen density of the skin is increased, that is, the collagen content is increased, and the skin is in a younger state.

Description

technical field [0001] The invention relates to the technical field of fine chemicals, in particular to a repair essence containing peony seed oil nano liposome and a preparation method thereof. Background technique [0002] Peony seed oil is a functional vegetable oil extracted from peony seeds, because it is rich in unsaturated fatty acids (especially α-linolenic acid), VA, VE, nicotinic acid, carotene, minerals and various amino acids. The saturated fatty acid content is 2-5 times that of other various seed oils, and it has good health care value and skin care value. Peony seed oil can promote the normal metabolism of skin epidermal cells, promote the microcirculation of skin capillaries and activate peripheral nerves, inhibit the dark yellow and aging of the skin caused by lipid peroxidation, slow down the whole process of skin aging, have anti-oxidation, maintain skin moisture content, improve Comprehensive skin care effects such as facial pigmentation, reducing wrinkl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/92A61K8/14A61K8/81A61K8/73A61K8/34A61K8/35A61Q19/00A61Q19/08
CPCA61K8/922A61K8/14A61K8/8152A61K8/735A61K8/345A61K8/35A61Q19/00A61Q19/08A61K2800/522A61K2800/413A61K2800/48A61K2800/30A61K2800/805A61K2800/82Y02A50/30
Inventor 常大伟张天宝
Owner 广州东智盟化妆品有限公司
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