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Amycolatopsis orientalis previously known as Streptomyces orientalis is a bacterium. It is considered an Actinobacterium species. Streptomyces orientalis are responsible for sore throat infections and wound infections in humans, and are also a significant cause of morbidity in goat populations.
Genetically engineered bacteria for producing a82846b and construction method and application thereof
The application discloses a genetically engineered bacterium for producing A82846B, namely, an engineered bacterium in which endogenous genes GrtfA, Lfp, or a combination of GrtfA and Lfp are integrated in the genome of a starting bacterium Amycolatopsis orientalis. The application also discloses a construction method of the genetically engineered bacterium, and a method for fermenting the genetically engineered bacterium and obtaining A82846B from a fermentation liquor. The genetically engineered bacterium overexpresses the introduced endogenous genes GrtfA, Lfp, or the combination of GrtfA and Lfp, and produces A82846B, thereby improving the yield of A82846B and the proportion of A82846B in total products, achieving the positive effects of improving the production efficiency of the target product A82846B, reducing the production cost, and reducing environmental pollution.
Owner:SHANGHAI INST OF PHARMA IND CO LTD +1