89results about How to "Small molecular size" patented technology

The invention relates to a modified antibody which contains two or more H chain V regions and two or more L chain V regions of monoclonal antibody and can transduce a signal into cells by crosslinking a cell surface molecule(s) to thereby serve as an agonist. The modified antibody can be used as a signal transduction agonist and, therefore, useful as a preventive and/or remedy for various diseases such as cancer, inflammation, hormone disorders and blood diseases.

Modified antibodies containing 2 or more H chain V domains and or more L chain V domains of a monoclonal antibody which can transduce a signal into cells by crosslinking a cell surface molecule, thereby serving as an agonist. Because of being usable as agonists for signal transduction, these modified antibodies are useful as, for example, preventives and/or remedies for various diseases such as cancer, inflammation, hormone disorders and blood diseases.

The invention discloses a high-strength aluminum alloy subjected to carbonitride complex treatment and a preparation method thereof. The alloy comprises the following components in percentage by weight: 2.0-3.2 percent of Cu, less than or equal to 0.2 percent of Mn, 0.2-0.5 percent of Mg, less than or equal to 0.01 percent of Cr, less than or equal to 0.01 percent of Ni, less than or equal to 0.1 percent of Zn, less than or equal to 0.15 percent of Ti, less than or equal to 0.5 percent of Si, less than or equal to 0.5 percent of Fe, and the balance of Al and inevitable trace impurities, wherein the carbonitride MX(C,N)Y is 0.05-2.5 percent of total mass of the furnace burden. The aluminum alloy has the characteristics of high strength and good casting performance.

Methods of increasing the permeability of corneal epithelium to facilitate the diffusion of agents into the collagen fibrillar network of the stroma are provided. Used in combination, these methods open the epithelium to facilitate diffusion of stabilization molecules into the stroma and dissociate bridging molecules from stromal collagen fibers, thereby priming the collagen fibrillar network for restabilization by stabilization molecules. These methods can be used to increase the effectiveness and longevity of non-invasive corneal reshaping, such as orthokeratology, for correcting myopia, hyperopia and astigmatism.

A proportional valve for controlling a gaseous medium, in particular hydrogen, including a nozzle body which has at least one pass-through opening, a closing element which releases and closes the pass-through opening on a valve seat, and an elastic sealing element, which provides a seal on the valve seat, the closing element being articulated with the aid of an articulated support.

The invention provides an aryl alkyl polyoxyethylene ether amine oxide surfactant and a preparation method and application thereof. The aryl alkyl polyoxyethylene ether amine oxide surfactant has the structural formula shown in the specification, wherein R is phenyl, cresyl, dimethylphenyl or ehtylphenyl; m and n are selected from integers of 0 to 15 respectively, the sum of m and n is 15, and integer x is an integer of 1 to 30. The invention further provides a preparation method of the aryl alkyl polyoxyethylene ether amine oxide surfactant and application of the aryl alkyl polyoxyethylene ether amine oxide surfactant to tertiary oil recovery. An aqueous solution of the aryl alkyl polyoxyethylene ether amine oxide surfactant provided by the invention has relatively high viscosity, can improve the swept volume, can reduce the interfacial tension, has good emulsifying performance and can reduce the viscosity of high-viscosity crude oil, so that the recovery ratio is improved; therefore, the aryl alkyl polyoxyethylene ether amine oxide surfactant has a good application prospect in the tertiary oil recovery.

The invention discloses an antibody-coupled drug as well as a preparation and the application thereof. The antibody-coupled drug is obtained from a heresy-base bifunctional-group polyethylene glycol covalent coupled drug molecule and a Fab' fragment, wherein the structure of the antibody-coupled drug is shown in formula I: Fab'-heresy base bifunctional group polyethylene glycol-drug molecule (1), wherein the Fab' is a fragment of an anti-CD20 antibody and the drug molecule is a cytotoxic drug molecule. According to the antibody-coupled drug, the F(ab')2 fragment degraded from the anti-CD20 antibody is reduced to a Fab' fragment of which the hinge area comprises two free thiols; and the Fab' fragment is then covalently coupled with the drug molecule by the heresy-base bifunctional-group polyethylene glycol, so that the antibody-coupled drug is obtained. The antibody-coupled drug prepared by the invention has the characteristics of fixed drug loading ratio and clear drug loading site structure; the antibody-coupled drug also retains the binding capacity of the anti-CD20 antibody to CD20 proteins, so that the antibody-coupled drug has targeting ability to the CD20-positive cells and is applicable to treatment of non-Hodgkin lymphomas.

The invention provides an aryl alkyl polyoxyethylene ether sulphobetaine surfactant as well as a preparation method and application thereof. The aryl alkyl polyoxyethylene ether sulphobetaine surfactant has the structural formula as shown in the specification, wherein R is phenyl, cresyl, dimethylphenyl or ehtylphenyl; m and n are selected from integers of 0 to 15 respectively, the sum of m and n is 15, and integer x is an integer of 1 to 30. The invention further provides a preparation method of the aryl alkyl polyoxyethylene ether sulphobetaine surfactant and application of the aryl alkyl polyoxyethylene ether sulphobetaine surfactant to tertiary oil recovery. An aqueous solution of the aryl alkyl polyoxyethylene ether sulphobetaine surfactant provided by the invention has relatively high viscosity, can improve the swept volume, can reduce the interfacial tension, has good emulsifying performance and can reduce the viscosity of high-viscosity crude oil, so that the recovery ratio is improved; therefore, the aryl alkyl polyoxyethylene ether sulphobetaine surfactant has a good application prospect in the tertiary oil recovery.

Provided are a multi-layered polymer package for a film battery and a combined package and current collector. The polymer package for the film battery and the combined package and current collector include a multi-layered polymer film having a construction of at least three layers, which includes a first polymer film, a second polymer film, and a third polymer film, the first, second, and third polymer films being made of different materials. The first polymer film is made of a hydrocarbon compound which is unsubstituted or substituted by a fluorine (F) atom. The second polymer film is made of an amorphous polymer. The third polymer film is made of a polymer having a tensile strength of a predetermined value or more and a tensile modulus of a predetermined value or more. In the combined package and current collector, a conductive layer is disposed on a surface of the multi-layered polymer film.

The invention provides an aryl alkyl polyoxyethylene ether carboxyl betaine surfactant and a preparation method and application thereof. The aryl alkyl polyoxyethylene ether carboxyl betaine surfactant has the structural formula shown in the specification, wherein R is phenyl, cresyl, dimethylphenyl or ehtylphenyl; m and n are selected from integers of 0 to 15 respectively, the sum of m and n is 15, and integer x is an integer of 1 to 30. The invention further provides a preparation method of the aryl alkyl polyoxyethylene ether carboxyl betaine surfactant and application of the aryl alkyl polyoxyethylene ether carboxyl betaine surfactant to tertiary oil recovery. An aqueous solution of the aryl alkyl polyoxyethylene ether carboxyl betaine surfactant provided by the invention has relatively high viscosity, can improve the swept volume, can reduce the interfacial tension, has good emulsifying performance and can reduce the viscosity of high-viscosity crude oil, so that the recovery ratio is improved; therefore, the aryl alkyl polyoxyethylene ether carboxyl betaine surfactant has a good application prospect in the tertiary oil recovery.

The invention discloses a branched organosilicone poly-guanidine durable leather antibacterial agent and a preparation method thereof. The antibacterial agent consists of an intermediate with a branched structure, polyamine, guanidine hydrochloride and low molecular organosiloxane, wherein the mole number of the intermediate with the branched structure is 0.1-1.2; the mole number of the polyamine is 0.3-8.0; the mole number of the guanidine hydrochloride is 0.5-5.0; and the mole number of the low molecular organosiloxane is 0.1-3.0. The antibacterial agent is obtained by undergoing a polyaddition reaction on the intermediate with the branched structure, polyamine, guanidine hydrochloride and low molecular organosiloxane. The antibacterial agent can be combined with leather, and has remarkable and durable sterilizing and moulding resisting effects in comparison to the conventional antibacterial agent. The antibacterial agent has biodegradability, is non-irritant to human bodies, and is a novel, safe and efficient leather antibacterial agent.

The invention provides a microcapsule double-aqueous-phase extraction method of tobacco clove oil, and applications thereof. The extraction method comprises the following steps: putting cloves into an ultrasonic extraction device, performing ultrasonic extraction by adopting an ethanol water solution as a solvent to obtain a clove extracting liquid, filtering, and adding a cyclodextrin capsule wall material and inorganic salt or inorganic base, evenly stirring and standing and layering; filtering and separating a cyclodextrin microcapsule layer, adding absolute ethanol into the cyclodextrin microcapsule layer and stirring for 30-60 min, and releasing a capsule core; and then filtering and separating the mixed solution to obtain an ethanol layer, and performing decompression distillation until no ethanol is distilled, thus obtaining the tobacco clove oil. The purification method is simple, mild in conditions, and environment-friendly, the purified clove oil selectively retains the characteristic component eugenol of cloves, another two main components, eugenol acetate and caryophyllene, obtained through common vapor distillation can be removed, the invention provides a method for separating and purifying eugenol from clove oil, and the eugenol is used for covering up miscellaneous gas in a cigarette and improving the aroma quality.

The invention relates to the field of fuel cells, and particularly discloses catalyst slurry for a fuel cell, a preparation method of the catalyst slurry and a membrane electrode. The preparation method of the catalyst slurry for the fuel cell comprises the following steps of S1) carrying out ultrasonic dispersion treatment on a perfluorosulfonic acid solution at 50-90 DEG C to obtain a perfluorosulfonic acid dispersion liquid; and S2) mixing the perfluorosulfonic acid dispersion liquid with a catalyst, a dispersing agent and deionized water, and emulsifying and dispersing to obtain the fuel cell catalyst slurry. By utilizing the preparation method, the problem of uneven dispersion of the proton conduction ionomer in the existing catalyst slurry can be solved, and the preparation method isused for improving the dispersity of the proton conduction ionomer in the catalyst slurry.

Disclosed are an organic germanium amine compound represented by chemical formula 1, recited in claim 1, and a film-forming method using the compound as a precursor. When the compound according to the present invention is used as a precursor, a germanium oxide film, a germanium nitride film, a metal germanium oxide film, a metal germanium nitride film, or the like, can be effectively formed by deposition.

The invention discloses a preparation method of a green and environmental protection tanning agent, comprising the following steps: weighing starch, deionized water, sodium hydrogen sulfite, CMC, SDS, silicone oil, op-10, sulfur alcohol and NaOH solution, adding the starch, the deionized water A, sodium hydrogen sulfite, CMC, SDS, the silicone oil, op-10, sulfur alcohol and the NaOH solution to a flask, heating to 50-60 DEG C while stirring, then adding hydrogen peroxide A, heating to 94-98 DEG C after constant temperature stirring for reaction, then cooling to 75-85 DEG C, adding HCL and then dropwise adding an initiator and a monomer, and cooling to room temperature after constant temperature stirring for reaction, thus obtaining the green and environmental protection tanning agent. The green and environmental protection tanning agent prepared according to the method disclosed by the invention can effectively improve the water resistance and shrinking temperature of leather, and de-tanning is not easy to cause.

The invention provides a cutaneous penetration essence. The cutaneous penetration essence comprises 72.69% of water, 21.90% of the extract of Cladosiphon novae-caledoniae, 1.78% of ceramide, 1.23% of sodium hyaluronate, 0.50% of glutamic acid, 0.50% of serine, 0.70% of panthenol, 0.20% of phenoxyethanol and 0.50% of lactic acid, wherein the extract of Cladosiphon novae-caledoniae is small-molecular particles of Cladosiphon novae-caledoniae extracted by using a wall breaking technology. According to the invention, the wall breaking technology is employed so as to allow the molecular particles of the pure plant-extracted component to have a minimal particle size; the prepared cutaneous penetration essence has extremely small molecular weight and strong penetration capability; and due to usage of a botanical formula, the essence can fully promote activity of skin cells, so the essence can be rapidly absorbed by skin when applied onto the skin and facilitates absorption of subsequently applied skin-care products.

The invention discloses a method for synthesizing low-nitrogen high-purity silicon carbide powder, and relates to the technical field of silicon carbide synthesis. The method comprises the steps of filling the raw material powder into a crucible with an exhaust hole, putting the crucible into a furnace, vacuumizing a furnace chamber, and heating; then injecting high-purity H2 into the furnace chamber to 750-850 mbar, and then vacuumizing the furnace chamber to 4.5*10<-6>-5.5*10<-6>mbar; and repeating for multiple times, heating the furnace chamber, injecting high-purity Ar and H2 into the furnace chamber according to the flow ratio of (9-10.5): 1, carrying out synthetic reaction and conversion synthetic reaction, and cooling to room temperature under the protection of Ar and H2 after the reaction is finished. The nitrogen concentration in the powder synthesis process can be effectively reduced, and the powder purity is improved; and the mixed raw materials are effectively prevented from escaping from the crucible in the powder synthesis process, and the reaction efficiency of the powder is improved.

The invention relates to the technical field of flocculating agent preparation, and solves problems of low polysaccharide yield and low polysaccharide flocculation activity in an existing microorganism. The invention discloses a method for preparing a flocculating agent by using Bacillus marinus. The method for preparing the flocculating agent by using the Bacillus marinus comprises the followingsteps: firstly, inoculating a Bacillus marinus strain into a solid culture medium and adding sterile water to the solid culture medium to prepare a strain liquid; secondly, inoculating the strain liquid into a liquid culture medium according to an inoculating quantity to ferment and culture the strain liquid so as to obtain a fermentation liquor; thirdly, adding a flocculation carrier to the fermentation liquor to continue to ferment the fermentation liquor so as to obtain a raw material liquor; and centrifugally separating and drying the raw material liquor to obtain an active polysaccharideflocculating agent. The method for preparing the flocculating agent by using the Bacillus marinus, disclosed by thei nvention, has the advantages that the yield of the active polysaccharide produced by using the Bacillus marinus strains is higher, and the flocculation activity of the active polysaccharide produced by using the Bacillus marinus strains is also higher.

The external medicine for treating vitiligo of the present invention is composed of A ointment and B liniment. The medicament of the present invention is different from the previous treatment scheme of simply treating vitiligo, and pioneered the "day and night double cycle therapy", which is administered continuously for 24 hours. Use A ointment at night to change the epidermal tissue structure of surface infection lesions, which is conducive to the smooth penetration of the drug and directly reach the lesion tissue, rapidly increase the activity of skin melanocytes, activate tyrosinase to accelerate melanin synthesis; use B liniment during the day to supplement various Active ingredients and trace elements can increase photosensitivity and promote melanin production, quickly and completely eliminate the pathogenic factors of vitiligo, increase the function of melanocytes and protect the accumulation of melanin in the skin to achieve the effect of non-recurrence. Multi-level and three-dimensional, prevention and treatment, symptoms and root causes are treated at the same time, the treatment method is unique, and the curative effect is reliable.

The invention discloses an anchoring agent with good thermal stability for a coal mine. The anchoring agent comprises a main material, a curing agent, a filling agent and distilled water. The main material comprises the following components in parts by weight: 100 parts of terephthalic unsaturated polyesters, 1-5 parts of dimethyl-p-toluidine, 2-6 parts of dimethylaniline and 5-15 parts of fumed silica. The curing agent comprises the following components in parts by weight: 100 parts of peroxycyclohexanone, 2-6 parts of carboxymethylcellulose and 2-7 parts of diethylene glycol. The filling agent comprises the following components in parts by weight: 15-30 parts of modified asphalt, 10-30 parts of calcium phosphate bone cement, 5-15 parts of hydroxyapatite, 15-30 parts of calcined clay, 2-10 parts of organobentonite, 5-15 parts of halloysite, 10-20 parts of kieselguhr, 20-40 parts of mica powder, and 15-35 parts of talcum powder. The weight part ratio of the main material, the filling agent and the distilled water is 100: 10-18: 20-40:50-150.

The invention discloses a nanometer metal-organic carboxylic acid complex colloid collector and a production method and application thereof. The nanometer metal-organic carboxylic acid complex colloidcollector is nanometer colloid particles formed by a metal-organic carboxylic acid complex; and the metal-organic carboxylic acid complex is generated from organic carboxylic acid and metal ions witha valance 2 or above under an alkaline condition. The collector has strong selective collection capability for metal minerals of calcite, scheelite, fluorite and the like, and can be used individually or can be subjected to functional synergistic assembly with an assistant surfactant to improve the collection capability and a foam structure of the collector so as to form an efficient flotation agent of metal minerals which contain tungsten, calcium, phosphorus and the like, and the production method of the nanometer metal-organic carboxylic acid complex colloid collector is simple and low incost, so that industrial production is benefited.