The invention provides mannosylated beta-lactoglobulin-
curcumin nanoparticles as well as a preparation method and application thereof, and belongs to the technical field of medicines. The preparation method provided by the invention comprises the following steps: mixing a
mannose solution and a beta-lactoglobulin solution, and sequentially carrying out first reaction,
dialysis and
freeze drying to obtain a mannosylated beta-lactoglobulin
monomer; the preparation method comprises the following steps: dissolving mannosylated beta-lactoglobulin in water to obtain a mannosylated beta-lactoglobulin
monomer solution, then mixing the mannosylated beta-lactoglobulin
monomer solution with a first
curcumin-
ethanol solution, then adjusting the pH value, then sequentially carrying out incubation and a second reaction to obtain a mannosylated beta-lactoglobulin-
curcumin compound, then carrying out a third reaction on the mannosylated beta-lactoglobulin-curcumin compound and a second curcumin-
ethanol solution to obtain the mannosylated beta- and finally, dissolving the mannosylated beta-lactoglobulin-curcumin primary nano-particles in an MES
buffer solution, adding absolute ethyl
alcohol, and carrying out a fourth reaction, so as to obtain the mannosylated beta-lactoglobulin-curcumin secondary nano-particles.