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Neoplastic, adj. (1) An abnormal mass of tissue, the growth of which exceeds and is uncoordinated with that of normal tissue, and persists in the same excessive manner after cessation of the stimuli evoking the change. (2) Any autonomous proliferation of cells, benign or malignant.
Chimeric protein toxins for expression by therapeutic bacteria
ActiveUS12642873B1Antibody mimetics/scaffoldsPeptide/protein ingredientsTherapeutic proteinTumor targeting
Bacteria with tumor-targeting capability express, surface displayed, secreted and / or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibitor as a separate molecule or as a fusion.
Owner:BERMUDES DAVID GORDON