Artificial crystal with antiproliferous medicine coating for preventing and treating after-cataract forming

An intraocular lens and anti-proliferation technology, applied in intraocular lenses, prostheses, medical science, etc., can solve the problems of short corneal action time, achieve no adverse reactions, inhibit growth, and reduce the formation rate of post-developmental disorders

Inactive Publication Date: 2007-10-17
刘红玲
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the problem that the existing drug-loaded intraocular lens has a short action time on the

Method used

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  • Artificial crystal with antiproliferous medicine coating for preventing and treating after-cataract forming
  • Artificial crystal with antiproliferous medicine coating for preventing and treating after-cataract forming

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Experimental program
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specific Embodiment approach 1

[0005] Specific embodiment one: In this embodiment, the intraocular lens with anti-proliferative drug coating for prevention and treatment of post-developmental disorder is made of a common intraocular lens and a coating containing anti-proliferative drug, wherein the coating containing anti-proliferative drug is bonded On the surface of ordinary intraocular lenses, the thickness of the coating is 3 to 20 microns.

specific Embodiment approach 2

[0006] Embodiment 2: The difference between this embodiment and Embodiment 1 is that the coating with anti-proliferative drugs can be applied to the non-optical zone part of the edge of the ordinary intraocular lens and the loops of the lens, the loops of the ordinary intraocular lens, the ordinary intraocular lens, etc. The surface of the intraocular lens and the haptics of the lens or the non-corneal contact surface of the ordinary IOL and the haptics of the lens. Other compositions are the same as in Embodiment 1.

specific Embodiment approach 3

[0007] Specific embodiment three: the difference between this embodiment and specific embodiment one is that ordinary intraocular lenses are polymethyl methacrylate intraocular crystals, silicone gel crystals, glass crystals, hydrogels, polycarbonate, polysiloxane Or one of the folding intraocular lenses made of silicone gel and hydrogel. Other compositions are the same as in Embodiment 1.

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Abstract

An artificial lens having stents coated with antiproliferative agents for prevention and treatment of the posterior capsule opacification, the invention relates to an artificial lens having stents coating for solving problems of time of present artificial lens loaded with medicine acting on cornea is short. The artificial lens having stents coated with antiproliferative agents for prevention and treatment of the posterior capsule opacification is prepared by ordinary artificial lens and coating with antiproliferative agents, wherein the coating with antiproliferative agents adheres on surface of ordinary artificial lens, thickness of the coating is 3 to 20 mum. The invention adopts macomolecule coating material to coat antiproliferative agents on artificial lens, slowly releases agents in capsules and ambitus cells, represses generation of lens epithelial cell, prevents and cures formation of the posterior capsule opacification. The agents of the invention act on cornea long time, capable of releasing effectively 90 to 120 days, have good therapeutic, patients use the artificial lens of the invention, formation rate of the posterior capsule opacification reduced greatly from more than 60% to 10% and without untoward reaction.

Description

technical field [0001] The invention relates to an artificial lens with drug coating. Background technique [0002] Posterior capsule opacification (PCO) is the most common complication after cataract and intraocular lens implantation, with an incidence rate as high as 60%, and the incidence rate of postoperative disorder in children with congenital cataract and intraocular lens implantation is as high as 100% , people are constantly exploring the effective methods of prevention and treatment of post-developmental disorder. The reason for the formation of after-growth disorder is currently considered to be that the main reason for the formation of after-growth disorder is that the residual lens epithelial cells (lensepithelium cells, IECs) after cataract surgery proliferate, migrate and transform into fibroblasts in the posterior capsule, forming fibrous membranes and forming fibroblasts. It leads to the turbidity of the posterior capsule, and the existence of the posterior...

Claims

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Application Information

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IPC IPC(8): A61L27/54A61L27/40A61F2/16
Inventor 刘红玲张晓梅程树军杨巍
Owner 刘红玲
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