Caspase inhibitors and the use thereof

A bacteriostatic and organic technology, applied in the field of pesticides, can solve the problems of no systematic research on the range of antibacterial concentration, differences in inhibitory effects, and no reports on patent applications for inhibition, so as to achieve no drug resistance and long duration of action. , the effect of low toxicity

Inactive Publication Date: 2008-04-09
GRIREM ADVANCED MATERIALS CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Their research conclusion only shows that rare earth complexes have a certain effect on antibacterial, but whether there is selectivity in the antibacterial effect of rare earth complexes, whether the inhibitory effect on different types of bacteria is the same, or even on the same type of bacteria Whether there is a difference in the inhibitory effect, the range of inhibitory concentration, etc. have not been systematically studied
At present, the research on the inhibitory effect of organic rare earth complexes on common plant pathogens and related patent applications have not been reported.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Preparation of binary complexes of rare earth chlorides (lanthanum, cerium, europium, ytterbium, dysprosium and yttrium) and 8-hydroxyquinoline

[0022] For the preparation of rare earth chlorides, use rare earth oxides (purity > 99.9%) in a molar ratio of 1:6, respectively dissolve in 1:1 hydrochloric acid, slowly concentrate to a paste, cool to room temperature, and place in phosphorus pentoxide Vacuum dry it for 5 hours and set aside.

[0023] Weigh 3mmol of dry lanthanum chloride (1.06g) and dissolve it in 25ml of dehydrated ethanol, add dropwise the dehydrated ethanol solution containing 6mmol of 8-hydroxyquinoline (0.879g) under stirring, a precipitate will form, and continue stirring at room temperature 24 hours. The precipitate was left to stand, filtered with suction, washed with an appropriate amount of absolute ethanol for 3 times, and then placed in phosphorus pentoxide and dried in vacuum for 4 hours to constant weight to obtain the compound of lanthanum a...

Embodiment 2

[0026] Preparation of ternary complexes of rare earth chlorides (lanthanum, cerium, europium, ytterbium, dysprosium and yttrium) with α-naoxyacetic acid, 8-hydroxyquinoline and

[0027] Weigh 1.29g of α-naoxyacetic acid and 0.44g of 8-hydroxyquinoline and dissolve them in 150ml of ethanol, add an aqueous solution containing 6mmol of sodium hydroxide to obtain a yellow transparent ethanol aqueous solution.

[0028] Weigh 3mmol of lanthanum chloride and dissolve it in 100ml of distilled water. Under constant stirring, add the yellow transparent ethanol aqueous solution into the lanthanum chloride aqueous solution dropwise, adjust the pH value to 6.5-7, and obtain a yellow precipitate; filter with suction and wash with deionized water 2 times to remove chloride ions, then wash 3 times with an appropriate amount of ethanol, and dry in a phosphorus pentoxide vacuum dryer to obtain a complex of lanthanum, α-naoxyacetic acid, and 8-hydroxyquinoline.

[0029] According to the same met...

Embodiment 3

[0031] Preparation of ternary complexes of rare earth chlorides (lanthanum, cerium, europium, ytterbium, dysprosium and yttrium) with salicylic acid and 8-hydroxyquinoline (solid phase method)

[0032] Weigh 0.005 mol of lanthanum chloride and 0.01 mol of sodium salicylate, grind them fully in an agate mortar, and the color of the system basically does not change; then weigh 0.005 mol of 8-hydroxyquinoline, grind them and pour them into the binary system , it was found that the color changed from colorless to orange-yellow rapidly, and the color gradually deepened, and it was fully ground for 0.5 hours, and finally cooled to orange-yellow; the solid powder was moved into a funnel with a sand core, washed 3 times with a small amount of distilled water and absolute ethanol, and the powder Put it in a drying oven, and dry it at 60° C. for 6 hours to obtain a solid powder product, and obtain a ternary complex of lanthanum chloride, salicylic acid and 8-hydroxyquinoline.

[0033] A...

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PUM

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Abstract

The invention discloses an organic rare earth bacteria inhibitor, mainly, a binary or ternary compound of lanthanon and 8-Hydroxyquinoline with other organic ligand. The invention also discloses the application of the organic rare earth bacteria inhibitor in preventing the plant bacteria and pests. The plant bacteria and pests include the rice bacteria and pests, the cotton bacteria and pests, the corn bacteria and pests, the vegetable bacteria and pests, and the like. The invention widens the application range of the rare earth to the pesticide filed; secondly, the invention comprehensively takes the advantage of the bacteriostatic function of the organic ligands and the rare earth, can perform double bacteriostatic effect with high bacteriostatic effect; in addition, the dosage of the organic rare earth bacteria inhibitor is less, the toxicity is low, the effective duration is long, the medicine resistance cannot be produced, and the production cost is low.

Description

technical field [0001] The invention belongs to the field of pesticides, and in particular relates to an organic rare earth antibacterial agent and its application. technical background [0002] In order to ensure the increase and harvest of crops, in addition to insecticide, weeding and rodent control, the prevention and control of diseases is also an important aspect. Compared with insecticides and herbicides, there are fewer varieties of bacteriostats and fungicides. In recent years, great progress has been made in the development of new varieties of fungicides, such as triazoles, amides, pyrimidine amines, methoxyacrylate fungicides, oxa(imid)azoles, pyrroles, amino acids, cinnamic acid Derivatives etc. [0003] Since the current fungicides are almost all organic compounds, there are some problems. For example, the use of organic fungicides will induce pests to develop resistance, and the resistance will continue to increase with the extension of use time, thus affect...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N55/02A01P3/00
Inventor 杨军张赫王甲辰刘向生伍艳平赵凤红
Owner GRIREM ADVANCED MATERIALS CO LTD
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