12 results about "Glutamic Acid Derivatives" patented technology

The invention relates to the technical field of oxidation resistance, in particular to a glutamic acid derivative, a preparation method thereof and application of the glutamic acid derivative in rhythm gene regulation and oxidation resistance. The glutamic acid derivative has a structure as shown in a formula I. The glutamic acid derivative provided by the invention can up-regulate expression of CLOCK protein and Per3 protein, can inhibit ROS in cells and up-regulate expression of Nrf2, and can be applied to relieving skin problems caused by disorder of circadian rhythm. # imgabs0 #

The invention discloses a chiral supramolecular fiber structure design based on glutamic acid derivative and pyrazine co-assembly, a preparation method and application in bone regeneration and vascular regeneration. The chiral supramolecular assembly disclosed by the invention is formed by co-assembling a glutamic acid derivative and pyrazine, is an all-organic three-dimensional spiral fiber material with an accurate and controllable three-dimensional topological configuration, and can realize coupling regeneration of bones and blood vessels by cooperatively regulating and controlling dual action mechanisms of osteogenic differentiation and angiogenesis; the compound can be used for efficiently treating complex bone defects and related bone diseases. In addition, raw materials and reagents are simple and easy to obtain, reaction conditions are mild, the preparation method is simple, and good application prospects are achieved.

The invention relates to the technical field of beauty skin care products, in particular to a glutamic acid derivative, a preparation method and application of the glutamic acid derivative in skin care products. The invention provides a compound with a structure as shown in a formula (I), which not only has rhythm protein up-regulation expression and oxidation resistance, but also has a good effect on up-regulation of aquaporin expression, silk protein expression and hypoxia inducible factor expression. The potential application prospects are realized on the effects of moisturizing the skin, repairing the barrier, promoting the ruddy skin and the like.

The present invention relates to a novel lipid derivative compound comprising an oligo-gamma-glutamic acid, a lipid nanoparticle composition comprising the same, and the like. According to the present invention, the compound can form lipid nanoparticles by replacing PEGylated lipids, and thus can prevent side effects such as anaphylaxis and has excellent in vivo stability.

A technique useful in the field of agri-horticulture such as a technique for preventing pest damage to plants is provided. Pest damage to plants is prevented by using various glutamic acid derivatives.

The present invention provides a technology useful in the agronomic horticultural field, such as a technology for controlling plant pests. Pests of plants are controlled by using various glutamic acid derivatives.

A technique useful in the field of agri-horticulture such as a technique for preventing pest damage to plants is provided. Pest damage to plants is prevented by using various glutamic acid derivatives.

The application provides a preparation method of a pyrrolidone intermediate. The method uses a continuous flow technology to obtain a target molecule through a substitution and a cyclization reaction of a cheap and readily available glutamic acid derivative and a halogenated ethylamine. The substitution reaction is directly used for the next step of the cyclization reaction without post-treatment. The total yield is greater than 80%, the chemical purity is greater than 99.1%, the optical purity is greater than 99.5% ee, the reaction safety factor is high, the cost is low, the efficiency is high, and the product yield and purity are high.

Provided are a novel lipid derivative compound including oligo-γ-glutamic acid, a lipid nanoparticle composition including the same, and the like. According to the present disclosure, the compound may form lipid nanoparticles by replacing PEGylated lipid, thereby preventing side effects such as anaphylaxis and exhibiting excellent in vivo stability, making it useful as a novel drug delivery system.

The invention relates to the technical field of degradable polyamide, in particular to a degradable bio-based polyamide composite material and a preparation method thereof.The degradable bio-based polyamide composite material is prepared from, by mass, 100 parts of bio-based polyamide master batch, 3-5 parts of flame retardant and 10-15 parts of modified lignin; the bio-based polyamide master batch is prepared through reaction of succinic acid, hexamethylenediamine and glutamic acid derivative monomers. The bio-based polyamide master batch is prepared through reaction of succinic acid, hexamethylenediamine and glutamic acid derivative monomers for the first time, a glutamic acid mannose Schif alkali monomer structure is embedded into a polyamide molecular chain, then a polyamide molecule contains a large number of hydroxyl side chains, the polyamide molecule is prone to moisture absorption and hydrolysis in the natural environment due to the design of polyhydroxyl, and meanwhile, the molecular weight of the polyamide master batch is reduced. Products such as glutamic acid, monosaccharide and the like obtained after hydrolysis of a polyamide molecular chain provide nutrients for growth and reproduction of microorganisms, and the biodegradation efficiency of polyamide in the natural environment is further improved.

The invention relates to the technical field of hydrocarbon fuel, in particular to a gelator, thixotropic hydrocarbon fuel gel and a preparation method and application thereof. The molecular structure of the gelator is shown in the specification. Wherein R1 is an alkyl group with the number of carbon atoms being 1-18, and R2 is an alkyl group with the number of carbon atoms being 4-18; the glutamic acid group in the molecular structure is L-type or D-type. The glutamic acid derivative gelator provided by the invention can be used for preparing organic gel from liquid hydrocarbon fuel exo-tetrahydrodicyclopentadiene, aviation kerosene and the like, and the organic gel material has excellent performance and thixotropy and has a good application prospect in the field of gel propellants.