7 results about "Glutamic Acid Derivatives" patented technology

The invention discloses a chiral supramolecular fiber structure design based on glutamic acid derivative and pyrazine co-assembly, a preparation method and application in bone regeneration and vascular regeneration. The chiral supramolecular assembly disclosed by the invention is formed by co-assembling a glutamic acid derivative and pyrazine, is an all-organic three-dimensional spiral fiber material with an accurate and controllable three-dimensional topological configuration, and can realize coupling regeneration of bones and blood vessels by cooperatively regulating and controlling dual action mechanisms of osteogenic differentiation and angiogenesis; the compound can be used for efficiently treating complex bone defects and related bone diseases. In addition, raw materials and reagents are simple and easy to obtain, reaction conditions are mild, the preparation method is simple, and good application prospects are achieved.

The invention relates to the technical field of beauty skin care products, in particular to a glutamic acid derivative, a preparation method and application of the glutamic acid derivative in skin care products. The invention provides a compound with a structure as shown in a formula (I), which not only has rhythm protein up-regulation expression and oxidation resistance, but also has a good effect on up-regulation of aquaporin expression, silk protein expression and hypoxia inducible factor expression. The potential application prospects are realized on the effects of moisturizing the skin, repairing the barrier, promoting the ruddy skin and the like.

The present invention relates to a novel lipid derivative compound comprising an oligo-gamma-glutamic acid, a lipid nanoparticle composition comprising the same, and the like. According to the present invention, the compound can form lipid nanoparticles by replacing PEGylated lipids, and thus can prevent side effects such as anaphylaxis and has excellent in vivo stability.

The application provides a preparation method of a pyrrolidone intermediate. The method uses a continuous flow technology to obtain a target molecule through a substitution and a cyclization reaction of a cheap and readily available glutamic acid derivative and a halogenated ethylamine. The substitution reaction is directly used for the next step of the cyclization reaction without post-treatment. The total yield is greater than 80%, the chemical purity is greater than 99.1%, the optical purity is greater than 99.5% ee, the reaction safety factor is high, the cost is low, the efficiency is high, and the product yield and purity are high.

Provided are a novel lipid derivative compound including oligo-γ-glutamic acid, a lipid nanoparticle composition including the same, and the like. According to the present disclosure, the compound may form lipid nanoparticles by replacing PEGylated lipid, thereby preventing side effects such as anaphylaxis and exhibiting excellent in vivo stability, making it useful as a novel drug delivery system.

The invention relates to the technical field of hydrocarbon fuel, in particular to a gelator, thixotropic hydrocarbon fuel gel and a preparation method and application thereof. The molecular structure of the gelator is shown in the specification. Wherein R1 is an alkyl group with the number of carbon atoms being 1-18, and R2 is an alkyl group with the number of carbon atoms being 4-18; the glutamic acid group in the molecular structure is L-type or D-type. The glutamic acid derivative gelator provided by the invention can be used for preparing organic gel from liquid hydrocarbon fuel exo-tetrahydrodicyclopentadiene, aviation kerosene and the like, and the organic gel material has excellent performance and thixotropy and has a good application prospect in the field of gel propellants.