Polyglycolic-acid-orientation nanometer fiber bundle and preparing method thereof

Abstract

The invention discloses a polyglycolic-acid-orientation nanometer fiber bundle and a preparing method thereof. The fiber bundle is formed by polyglycolic acid nanometer fibers wrapped with a polylactic acid-hydroxyacetic acid copolymer. According to the preparing method, the molecular weight, the optical isomer content and the mixing ratio of polylactic acid and polyglycolic acid are preferred, and polylactic acid / polyglycolic acid blend fibers are produced at the suitable spinning temperature and the spinning speed. Under the specific conditions such as the preferred raw material components and sufficiently-strong stretch flow fields, the polyglycolic acid nanometer fibers (the average diameter is 50 nanometers to 200 nanometers) are in-situ formed in the forming process of the polylacticacid / polyglycolic acid blend fibers. The directional-arrangement polyglycolic-acid-orientation nanometer fiber bundle has excellent heat resistance, can keep the stability of the size and the orientation structure at the temperature of being higher than 120 DEG C, and has good degradability resistance, and a performance bottleneck that a conventional polyglycolic-acid nanometer fiber bundle is easy to disorientate and easy to degrade is broken through.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and relates to a polyglycolic acid oriented nanofiber bundle with directional arrangement and a preparation method thereof. Background technique [0002] Polyglycolic acid has good biocompatibility and biodegradability, and has broad application prospects in many fields such as tissue engineering, medical supplies, and flexible packaging materials. In particular, oriented polyglycolic acid oriented nanofiber bundles / membranes can be used for cell culture or artificial organ templates (artificial bones, artificial nerve conduits) of specific tissues (muscle, ligament, nerve, bone, etc.) that exhibit high directionality in growth and differentiation. , artificial blood vessels, etc.), drug slow-release carriers and tissue repair scaffolds, etc., can also be used in organic field effect transistors, gas sensing and electrochemical sensing that require good charge transport. These fields a...

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Problems solved by technology

[0004] Although the above known technologies can obtain oriented polyglycolic acid nanofiber bundles, they also have the following limitations: (1) under the current technical conditions, the production efficiency of electrospinning is low, and the process conditions such as shaft collection are complicated; (2) Solvent used in electrospinning: Hexafluoroisopropanol has strong polarity, high toxicity, and is not environmentally friendly; (3) During the electrospinning process, the concentration of the spinning solution is too low, which makes the polymer molecular chains relax rapidly and cannot form molecules Nanofibers with a higher degree of chain orientation; (4) During the electrospinning and collection process, there is stress freezing in the PGA nanofibers, and when heated to near its glass transition temperature (temperature higher than 40 ° C), the stress relaxes, which will make The structure of nanofibers is unstable, such as bending, or even greatly reducing the degree of alignment, which greatly limits its application and promotion; (5) It has been publicly reported that the molecular chain orientation degree of polylactic acid stereocomplex crystal nanofibers prepared by melt spinning is 0

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