50results about How to "Realize large-scale production" patented technology

The application discloses a large-scale electronic-grade hydrogen purification system and process, and belongs to the technical field of gas separation. The process implemented by the large-scale electronic-grade hydrogen purification system comprises the following steps: raw gas enters a first normal-temperature pressure swing adsorption device under a set pressure, and high-purity hydrogen is continuously produced through pressure swing adsorption under normal-temperature conditions; the hydrogen enters a temperature swing adsorption device to remove residual moisture in the hydrogen, and high-quality hydrogen meeting the electronic-grade hydrogen standard is obtained; desorption gas of the first normal-temperature pressure swing adsorption device and regeneration waste gas of the temperature swing adsorption device are compressed and then enter a second normal-temperature pressure swing adsorption device to be further concentrated, and product gas crude hydrogen is obtained; the crude hydrogen is mixed with the raw gas and is sent into the first normal-temperature pressure swing adsorption device. The application is ingenious in conception and scientific in design, and realizes large-scale production of electronic-grade hydrogen through a two-stage pressure swing adsorption coupling drying process.

The invention belongs to the technical field of synthesis of extraction agents, and particularly relates to a preparation method and application of amido diphosphinic acid. The preparation method comprises the following steps: (1) mixing a solvent, primary amine, cyclohexylphosphinic acid and inorganic acid, and heating until the solution is clear and transparent; (2) adding a formaldehyde solution or paraformaldehyde into the clear and transparent solution for reaction; and (3) removing a water phase from the mixture obtained after the reaction in the step (2) is finished, dissolving jelly obtained after the water phase is removed by using dichloromethane, and carrying out washing, rotary evaporation and drying to obtain the amido diphosphinic acid.

The invention discloses a traditional Chinese medicine tea drink for preventing and treating oral mucosa diseases and a preparation method of the traditional Chinese medicine tea drink. The traditional Chinese medicine tea drink is prepared from 10-15 parts of radix astragali, 8-12 parts of radix codonopsis, 6-10 parts of radix salviae miltiorrhizae, 5-9 parts of radix angelicae sinensis, 3-6 parts of fructus psoraleae, 6-9 parts of rhizoma polygonati, 6-9 parts of radix adenophorae, 6-10 parts of rhizoma atractylodis macrocephalae, 5-9 parts of radix ophiopogonis, 3-5 parts of radix glycyrrhizae, 4-6 parts of pericarpium citri reticulatae and 5-8 parts of herba taraxaci. Aiming at the core pathogenesis of low immunity, long-term deficiency, long-term deficiency and kidney-yang insufficiency of patients suffering from oral mucosa diseases, qi tonifying, blood activating and kidney-qi strengthening are taken as a core treatment method, the formula is scientific and reasonable, all the medicinal materials act synergistically, the overall immune function of the body is adjusted, T lymphocyte subpopulation imbalance and cell factor network disorder are improved, and the curative effect is good. The oral mucosa microcirculation is improved, local inflammation is relieved, the immunity of a patient is improved fundamentally, the recurrence rate of oral mucosa diseases is reduced, and the problems that an existing tea drink is not high in pertinence and limited in curative effect are solved. The tea drink is appropriate in taste, good in compliance, high in safety and suitable for people with various oral mucosa diseases and low immunity.

The patent relates to the technical field of tobacco, and particularly relates to a conveying system for a paper-process sheet drying oven and the paper-process sheet drying oven. The conveying system comprises a conveying device, a first deviation rectifying device and a second deviation rectifying device. The first deviation rectifying device and the second deviation rectifying device are both used to provide displacement in a deviation rectifying direction to the conveying belt, the deviation rectifying direction is perpendicular to the length direction of the conveying belt, the distance between the first deviation rectifying device and the end driving roller is not greater than 10%, 20% or 25% of the length direction size of the transmission assembly, and the second deviation rectifying device is arranged substantially symmetrically to the middle line of the transmission assembly in the length direction of the first deviation rectifying device. The patent can better solve the deviation problem of the conveying belt, save labor cost, improve production efficiency and reduce the labor intensity of the operator. The deviation rectifying frequency of the first deviation rectifying device and the second deviation rectifying device is lower during the working process, and the first deviation rectifying device and the second deviation rectifying device are more suitable for deviation rectifying of long-distance belt conveying systems and have a longer service life.

The invention belongs to the related technical field of intelligent sportswear, and particularly relates to a solar AI intelligent sportswear, which comprises an outdoor jacket main body, at least three flexible amorphous silicon film power generation modules, an energy management module, an energy storage unit, an electricity load and a flexible conductive circuit for interconnecting the flexible amorphous silicon film power generation modules, the energy management module, the energy storage unit and the electricity load. The flexible amorphous silicon film power generation modules are optimally arranged in high-sunlight areas such as the rear of the brim and the shoulders and are combined with the garment through the hot-pressing composite technology, sewing needle holes are avoided, the original elasticity, soft touch feeling and appearance smoothness of the garment are kept, and the service life of the garment is prolonged. The non-sensibility of the power generation function and the non-destructive effect of the clothes movement function are realized; according to the power generation module, ETFE / PI'sandwich 'packaging and ultrasonic welding edge sealing are adopted, and a waterproof moisture-permeable hot melt adhesive composite technology is matched, so that multi-layer protection is jointly formed.

The invention discloses ultra-microporous synergistic powder for tank mixing of pesticides as well as a preparation method and application of the ultra-microporous synergistic powder, and belongs to the technical field of functional auxiliary agents of the pesticides. The powder takes a natural porous material as a raw material, is prepared through raw material pretreatment, inert atmosphere high-temperature calcination activation, superfine grinding and homogeneous compounding, and contains 85-98% of superfine porous powder, 1-10% of a dispersing agent and 1-5% of a wetting penetrant. The key of application is that the barrel mixing sequence of diluting the pesticide and then adding the powder is adopted, the adding amount is 1%-5% of the total weight of the pesticide liquid, the powder can efficiently adsorb effective components of the pesticide, and the light stability and the lasting period of the pesticide are remarkably improved through the ultraviolet shielding effect and the adsorption-desorption slow release effect of the ultra-micropore structure. The product and the using method are specially designed for terminal users, operation is easy and convenient, and efficiency is remarkable.

The application provides a layered preparation method and system of a diamond heat sink sheet, and the method comprises the following steps: preparing a crystal direction anchoring microstructure on a growth surface of a substrate and a moment buffer layer on a non-growth surface; obtaining a first layer of diamond through crystal direction anchoring, and generating a reverse moment on the growth surface through the moment buffer layer; removing surface defects on the diamond surface to form an atomic level step; depositing a liquid metal on the atomic level step for stress release, and then removing the liquid metal; continuously growing a second layer of diamond, and accurately controlling the stress state of the second layer of diamond; and cooling to obtain a crack-free diamond heat sink sheet. Through the synergistic process design of the diamond layering construction and the reverse moment buffer, the application blocks the path of stress accumulation and crack initiation and expansion, effectively solves the cracking problem in the preparation process of the diamond heat sink sheet, balances the process feasibility and the product performance stability, greatly improves the yield and the structural integrity of the diamond heat sink sheet, and reduces the production cost.

The application belongs to the technical field of functional antibodies, and discloses a nano antibody against H7 subtype influenza virus and application of the nano antibody. 50 The nano antibody has strong binding activity (EC50 is 0.052 μg / mL) with H7 subtype influenza virus Anhui13-HA protein, has strong neutralization activity (IC50 is 0.029 μg / mL) on H7 subtype influenza virus Anhui13, and can be used for detecting H7 subtype influenza virus and / or HA protein of H7 subtype influenza virus, and provides a thought for preventing and / or treating diseases caused by H7 subtype influenza virus. 50 In addition, the nano antibody has strong binding activity (EC50 is 0.064 μg / mL) with H7 subtype influenza virus SF003-HA protein, has weak neutralization activity (IC50 is 6.033 μg / mL) on H7 subtype influenza virus SF003, and can be used for detecting H7 subtype influenza virus and / or HA protein of H7 subtype influenza virus, and provides a thought for preventing and / or treating diseases caused by H7 subtype influenza virus. 50 50 ​​

The invention relates to the technical field of anion exchange membranes, in particular to a cross-linked polyaryl anion exchange membrane and a preparation method thereof. The preparation method of the anion exchange membrane comprises the following steps: S1, synthesizing a side chain type unfunctionalized polymer by using a benzene-containing monomer and 7-bromo-1, 1, 1-trifluoroheptane-2-ketone as raw materials through an acid catalytic polymerization reaction; s2, introducing an ionic group and a cross-linkable group through a functional reaction with a functional reagent and a cross-linking agent to obtain a functional polymer solution; s3, finally, the cross-linking type polyaryl anion exchange membrane is obtained through a flat plate tape casting method and an anion exchange reaction. The preparation method has the advantages of simple synthesis steps and simple film forming process, and can be used for large-scale production. The prepared anion exchange membrane has excellent ionic conductivity, alkali resistance and mechanical property.

The invention relates to the technical field of monatomic catalysis, and discloses a monatomic catalyst as well as a preparation method and application thereof. The monatomic catalyst comprises a nitrogen-doped porous carbon carrier and transition metal dispersed on the surface of the nitrogen-doped porous carbon carrier in a monatomic form; wherein the loading capacity of the transition metal is 0.2-2% by mass; on the basis of the total amount of the catalyst, the content of nitrogen in the nitrogen-doped porous carbon carrier is 0.5-4% by mass. Transition metal in the monatomic catalyst is uniformly dispersed on the surface of the nitrogen-doped porous carbon carrier in a monatomic form, and the monatomic catalyst has high activity and high stability when being used as a catalyst for an electrocatalytic oxygen reduction reaction, a hydrogen evolution reaction, an oxygen evolution reaction or a fuel cell.

This application relates to the field of oxide target technology, specifically disclosing an ITZO target and its preparation method. The preparation method of the ITZO target includes the following steps: applying an In-containing... 3+ Sn 4+ Zn 2+ A complexing agent is added to the solution to obtain a mixed solution; the mixed solution is then added dropwise to an ammonia solution and aged to obtain a precursor precipitate; the precursor precipitate is then subjected to spray pyrolysis, cold isostatic pressing, and warm isostatic pressing to obtain an ITZO preform; the ITZO preform is then subjected to programmed temperature calcination and programmed temperature cooling to obtain an ITZO target. This application obtains a uniformly composed and highly dense ITZO target by dynamically controlling the composition of the mixed gas during the programmed temperature cooling process through two static pressing treatments; using this target, a transparent conductive film with high visible light transmittance and excellent electrical properties can be prepared by sputtering, solving the technical problems of uneven composition, low density, and poor quality of sputtered films in existing targets.

The invention discloses a solid-state combined aerosol product and a preparation method thereof, and relates to the technical field of heating cigarette products. The solid-state combined aerosol product provided by the invention comprises a fuming section and a filtering section, the fuming section comprises a functional fuming section and a solid core, the functional fuming section is used for providing aerosol, and the solid core is used for providing tobacco aroma components; the functional fuming section is matched with the solid core, so that the fuming effect of the whole product is effectively improved, meanwhile, the processing performance of the product is improved, the continuous production efficiency is greatly improved, and the storage time is prolonged from three months to more than one year. The improved aerosol product can be matched with various external source type heating appliances such as ring type heating appliances, air heating appliances, ring type and air heating appliances and the like. The preparation method of the solid-state combined aerosol product is simple and convenient, and large-scale production can be realized.

This invention relates to the field of cosmetic technology, specifically to a method for preparing and applying a supramolecular solvent containing puerarin. The supramolecular solvent containing puerarin comprises: puerarin, a hydrogen bond donor, and a hydrogen bond acceptor; the molar ratio of the hydrogen bond donor to the acceptor is 1-3:1-2. This invention utilizes a supramolecular solvent containing puerarin formed by weak interactions such as hydrogen bonds, which can effectively solve problems such as easy precipitation of puerarin in products and poor transdermal absorption. Simultaneously, this supramolecular solvent containing puerarin can synergistically enhance the effect of puerarin in oil-controlling and acne-reducing products. Cosmetics made using the supramolecular solvent prepared by this invention have good oil-controlling and soothing effects, and the preparation process is simple, easy to scale up, and has stable properties.

The utility model relates to the technical field of vegetable product treatment, and discloses vegetable product nutritional ingredient stabilizing treatment equipment which comprises a cleaning frame, a fixing plate is fixedly connected to the top of the cleaning frame, a cleaning assembly used for decontaminating the cleaning frame is fixedly connected to the interior of the cleaning frame, a first motor is fixedly connected to the top of the fixing plate, and a second motor is fixedly connected to the top of the fixing plate. The driving end of the first motor is fixedly connected with an elliptic column, the top of the fixing plate is fixedly connected with a connecting column, the interior of the connecting column is slidably connected with a sliding column, the interior of the sliding column is rotatably connected with an extrusion column, the interior of the sliding column is fixedly connected with a spring, and the exterior of the extrusion column is fixedly connected with a rotating rod. According to the vegetable product quantitative feeding device, accurate quantitative feeding is guaranteed, quantitative feeding treatment on vegetable products is achieved, harmful microorganisms on the surfaces and in the vegetable products can be effectively killed, the number and activity of the microorganisms are reduced, and the spoilage speed of the vegetable products is slowed down.

The application discloses an ultra-high molecular weight polyethylene fiber reinforced polyether ether ketone composite material and a preparation method and application thereof, and belongs to the technical field of high-performance fiber reinforced resin matrix composite materials.The application realizes the synergy of surface activation and thermal protection of the ultra-high molecular weight polyethylene fiber by means of a synergistic modification strategy of photo-initiated grafting and elastomer coating and a fast hot-pressing composite process, and significantly improves the interfacial bonding capacity with a polyether ether ketone matrix on the premise of maintaining the original mechanical properties of the ultra-high molecular weight polyethylene fiber.

The invention discloses a high-stability SPC aluminum-wood honeycomb composite board and a preparation method thereof.The board sequentially comprises a first SPC stone crystal layer, a first eucalyptus veneer layer, an aluminum honeycomb core layer, a second eucalyptus veneer layer and a second SPC stone crystal layer from top to bottom, all the layers are compounded into a whole through double-component AB formaldehyde-free glue in a cold pressing mode, and the thickness and technological parameters of all the layers have the optimal range; the SPC stone crystal layer can be replaced by an aluminum veneer. The preparation method comprises six steps of eucalyptus veneer pretreatment, SPC stone crystal layer treatment and the like. The composite board is stable in structure, high in nail-holding power, waterproof, environment-friendly, excellent in fire prevention and sound insulation, easy to prepare, capable of achieving mass production and suitable for being used in multi-scene decoration and structures.

This invention relates to an electroactive porphyrin-based conjugated microporous polymer material, its preparation method, and its applications. The porphyrin-based conjugated microporous polymer is obtained from raw materials containing porphyrin-based monomers and aromatic amine monomers through a coupling reaction. The electroactive porphyrin-based conjugated microporous polymer material of this invention exhibits excellent electrochemical performance as an electrode material. Lithium-ion capacitors constructed using this material possess characteristics such as high specific capacitance, high energy density, fast charging rate, and long cycle life. This invention has good application potential in lightweight, high-specific-energy, fast-charging energy storage devices.

This invention provides the application of a uterine-derived Sphingomonas DS-28 strain and its metabolites in the treatment of endometritis, relating to the field of microbial technology. The Sphingomonas DS-28 strain provided by this invention possesses uterine colonization ability, good niche adaptability, and significant efficacy in treating Escherichia coli-induced endometritis. Animal experiments show that the preparation of this strain can effectively alleviate uterine redness and swelling, reduce pathological damage, and significantly reduce [the condition / progression]. TNF-alpha , IL-6 , IL-8 It inhibits gene expression and suppresses the NF-κB signaling pathway, exhibiting superior anti-inflammatory and tissue repair effects compared to other Sphingomonas strains C3-25.1, C3-41.1, and C3-42.1. Furthermore, the metabiotic preparation of this strain can also alleviate Escherichia coli-induced endometritis in mice, improve uterine redness and swelling, and reduce pathological damage.

The application relates to a high-selectivity acid-resistant nanofiltration membrane and a preparation method and application thereof, and belongs to the field of membrane separation technology. The preparation method of the high-selectivity acid-resistant nanofiltration membrane comprises the following steps: (1) soaking a polysulfone membrane in an aqueous solution containing a strong oxidant and a metal chloride; (2) immersing the membrane treated in the step (1) into a n-hexane solution containing a pyrrole molecule and standing; (3) spraying a mixed ethanol solution of phenol and formaldehyde onto the membrane treated in the step (2); and (4) post-treating the membrane treated in the step (3) in a hot sodium hydroxide solution containing a surfactant to obtain the high-selectivity acid-resistant nanofiltration membrane. The application has the advantages of simple process, easily-obtained raw materials and suitability for industrial production. Meanwhile, the high-selectivity acid-resistant nanofiltration membrane has high selectivity of divalent ions and monovalent ions on the premise of strong acid resistance, and is suitable for salt separation treatment of acid industrial wastewater.

This utility model discloses a bending die for enclosed workpieces, comprising a first upper die body, a second upper die body, and an upper die pressure beam. The first upper die body is located on the upper left side of the upper die pressure beam, and the second upper die body is located on the upper right side of the upper die pressure beam, and are connected to the upper die pressure beam via a hinge. The first upper die body, the second upper die body, and the upper die pressure beam enclose an interference-free space for forming enclosed workpieces. Simultaneously, the hinge allows the second upper die body and the upper die pressure beam to be separated, and also allows the upper die pressure beam to rotate around the hinge, thereby facilitating the removal of the formed enclosed workpiece. This utility model not only improves the convenience and efficiency of production operations but also facilitates large-scale production.

The invention discloses a composite material for environment-degradable plant-based tipping paper for cigarettes and a preparation method of the composite material, and belongs to the technical field of biodegradable high polymer materials. The composite material comprises the following components in parts by weight: 50-80 parts of polylactic acid, 15-40 parts of plant fibers, 5-15 parts of a bio-based interfacial compatibilizer and 1-10 parts of surface sulfonated lignin nanoparticles. The preparation method comprises the steps of melt blending granulation and tape casting. The core of the invention lies in that the surface sulfonated lignin nanoparticles serve as an interface reinforcing bridge and a nano pore-foaming agent in the specific composite system at the same time, and the technical contradiction that high strength and high air permeability of the degradable material cannot be achieved at the same time is synergistically solved. The degradation rate of the obtained film within 180 days under the composting condition is larger than 90%, the longitudinal tensile strength is larger than or equal to 38 MPa, the air permeability is 20-30 CU, the industrial standard of tipping paper for cigarettes is comprehensively met, and an ideal green alternative scheme is provided for traditional non-degradable tipping paper.

This invention discloses an antioxidant peptide derived from deep-sea cold seeps and its applications, belonging to the fields of bioinformatics, development of microbial resources in extreme environments, and antioxidant peptide technology. The antioxidant peptide CSAOP4 obtained by this invention originates from a high-salt, low-temperature, high-pressure, oligotrophic environment, exhibiting excellent stability and activity. Adding 0.1 mg / mL of this antioxidant peptide resulted in an ABTS free radical scavenging rate of 44.45%, significantly superior to CSAOP1, CSAOP2, and CSAOP3 (ABTS free radical scavenging rates of 7.32%, 15.14%, and 27.71%, respectively). It is suitable for cosmetic production processes and can be mass-produced through solid-phase synthesis, offering simple preparation and high cost-effectiveness. This deep-sea cold seep antioxidant peptide is suitable for application in the cosmetic field, significantly extending the shelf life of cosmetics and reducing the risk of oxidative deterioration, showing broad application prospects.

This invention discloses a silicon-based ceramic core with high-temperature strength yielding properties and its preparation method. The silicon-based ceramic core includes a core matrix, strength yielding units, and a surface dense layer. The strength yielding units are uniformly embedded inside the core matrix, and the surface dense layer is uniformly coated on the outer surface of the core matrix. The mass ratio of the core matrix to the strength yielding units is 3-5.6:1. The preparation method includes the following steps: preparing a core matrix slurry, strength yielding units, and a surface dense layer slurry; mixing the strength yielding units into the core matrix slurry to obtain a mixed slurry; injecting the mixed slurry into a ceramic core mold for filling and die casting to obtain a wet blank; coating the outer surface of the wet blank with the surface dense layer slurry, drying it to obtain a silicon-based ceramic core blank, followed by degreasing and sintering. This invention solves the problems in the prior art such as the mismatch between the high-temperature strength of the ceramic core and the solidification stress of the alloy liquid, casting hot cracking, internal cavity recrystallization, core leakage, core deviation, and difficulty in core removal.

This invention relates to the field of chemical production technology and discloses an apparatus and method for the large-scale production of boron nitride nanomaterials. The apparatus includes a vacuum chamber, a cooling water circulation system, a vacuum pumping system, an exhaust system, a gas path, an automatic stirring device, a material reaction container, and a heating device. The automatic stirring device controls the mixing and stirring of the materials. The material reaction container is connected to multiple evenly distributed air inlets. The heating device surrounds the material reaction container and controls the reaction temperature. This invention improves the thermal treatment effect and chemical reaction efficiency of the raw materials in the gas by equipping the material reaction container with an automatic stirring device and multiple densely distributed air inlets, effectively increasing the quality and quantity of materials processed per batch and improving the production efficiency of boron nitride nanomaterials. The apparatus is simple, has low manufacturing cost, and is easy to scale up; the production method is simple, energy-efficient, and pollution-free, meeting the needs of large-scale preparation of boron nitride nanomaterials.

The invention discloses a beta-glucosidase BglSK mutant and an application of the beta-glucosidase BglSK mutant. The BglSK mutant is mutated by taking an amino acid sequence as shown in SEQ ID NO. 1 as a benchmark. According to the beta-glucosidase BglSK mutant disclosed by the invention, one or more amino acid residues are introduced at a specific site for substitution, so that the thermal stability and / or catalytic activity of beta-glucosidase are / is remarkably improved; in addition, ginsenoside Rd or analogues thereof can be efficiently catalyzed, and rare ginsenoside F2 and / or rare ginsenoside CK can be directionally generated. According to the beta-glucosidase BglSK mutant disclosed by the invention, large-scale production of rare ginsenoside is successfully realized, and the beta-glucosidase BglSK mutant has huge industrial application prospect and value.

The application discloses a preparation method of a copper-cobalt-doped carbon nitride electrocatalyst, and a product and application thereof. The copper-cobalt-doped carbon nitride electrocatalyst is prepared by taking 3-amino-1,2,4-triazole as a precursor, 1,10-phenanthroline as a ligand, and a copper source and a cobalt source as metal sources, and has a C3N5 carrier and Cu / Co dispersed in the carrier. The catalyst has rich active sites and excellent conductivity, and through the synergistic effect of copper and cobalt, the hydrogen evolution side reaction is inhibited, and the activity, selectivity and stability of the electrocatalytic reduction of nitrate to produce ammonia are improved. The problems of low activity, low faradic efficiency, poor stability and high cost of the existing electrocatalytic nitrate reduction ammonia catalyst are effectively solved. The preparation method adopts a non-noble metal + non-metal substrate, raw materials are easy to obtain, the preparation process is simple, and the cost is low, and thus the method can realize large-scale production. The obtained catalyst is suitable for the field of electrocatalytic reduction of nitrate to produce ammonia, can realize water nitrate pollutant treatment and high-value ammonia resource recycling, and has dual benefits of environmental protection and economy.

The present application relates to the technical field of 3D printing, and particularly relates to a 3D printing method and device with a fog collecting and droplet manipulating function bionic surface, which is used for realizing the preparation and adjustment of the macroscopic and microscopic structures of the intelligent bionic surface with high efficient water collecting function. The printing device contains five hardware parts, including a three-phase material supply system, a digital flow control extrusion system, an ultraviolet polymerization system, a three-dimensional motion platform and an intelligent control system. Through the hardware design of the digital flow control extrusion system containing three-phase materials and the pipeline flow design, combined with the material design of the mutual insolubility and emulsification breaking capacity of the inner phase, the intermediate phase and the outer phase, according to the optimization of the process parameters, the direct formation of the bionic spindle knot shape and the real-time adjustment of the spindle knot size and spacing of the microfiber main shaft are realized, which has great application potential in realizing efficient fog collection and droplet manipulation.

This invention provides a horse chestnut tiglyl-CoA ligase gene. AcCCL3 This invention relates to the AcCCL3 protein and its applications, belonging to the field of gene technology. For the first time, this invention has identified and verified the key enzyme gene responsible for the biosynthesis of tigrazol-CoA in horse chestnut. AcCCL3 This invention provides a complete analysis of its biosynthetic pathway, filling a knowledge gap in this field. It can be based on... AcCCL3 This gene, through synthetic biology strategies and an engineered system, has achieved the synthesis of tiglyl-CoA, completely eliminating reliance on traditional, complex, and demanding chemical synthesis routes. This significantly reduces production costs from the source, enabling large-scale production and successfully solving the core challenge of large-scale, stable preparation and supply of tiglyl-CoA. It also breaks through the key precursor constraints that have hindered the biosynthetic research, drug development, and industrial production of a series of high-value aescin compounds, represented by aescin A.

The application discloses a polypeptide and derivatives thereof targeting B7H3 (CD276), a drug conjugate, a pharmaceutical composition, a preparation method and a tumor diagnosis and treatment application, and belongs to the technical field of biological medicines. Existing B7H3 monoclonal antibodies and CAR-T have defects such as large molecular weight, poor penetration, high cost, easy immunogenicity and the like, and there are few targeting peptides. The application provides a peptide with a sequence of Gly ‑ Val-Pro-Tyr-Ala-Gln-Pro-Leu, the polypeptide has strong B7H3 binding specificity; derivatives can be obtained by modifying the polypeptide in various ways; the polypeptide can be coupled with a chemotherapeutic drug such as camptothecin to form a polypeptide drug conjugate. The polypeptide and the coupled drug can be prepared into a targeted preparation, are specifically enriched in B7H3 positive tumors such as pancreatic cancer, lung cancer and breast cancer, reduce drug toxic side effects, and have dual application values of diagnosis and treatment.