146 results about "Benzyl benzoat" patented technology

A nonaqueous, single-phase vehicle that is capable of suspending an active agent. The nonaqueous, single-phase vehicle includes at least one solvent and at least one polymer and is formulated to exhibit phase separation upon contact with an aqueous environment. The at least one solvent may be selected from the group consisting of benzyl benzoate, decanol, ethyl hexyl lactate, and mixtures thereof and the at least one polymer may be selected from the group consisting of a polyester, pyrrolidone, ester of an unsaturated alcohol, ether of an unsaturated alcohol, polyoxyethylenepolyoxypropylene block copolymer, and mixtures thereof. In one embodiment, the at least one solvent is benzyl benzoate and the at least one polymer is polyvinylpyrrolidone. A stable, nonaqueous suspension formulation that includes the nonaqueous, single-phase vehicle and an active agent, and a method of forming the same, are also disclosed.

The invention relates to a no-clean lead-free tin welding wire and a preparation method thereof, wherein the lead-free welding wire is composed of 2 to 3 percent of flux and 97 to 98 percent of lead-free solder. The lead-free solder is composed of 0.5 to 0.7 percent of Cu, 0.03 to 0.05 percent of Ni, 0.01 to 0.02 percent of P, 0.005 to 0.01 percent of Ga and the remnant amount of Sn. The No-clean flux is composed of 1.0 to 4.0 percent of organic acid active agent, 0.5 to 5.0 percent of halogenated derivative active solvent, 2.0 to 5.0 percent of heat-resistant resin , 1.0 to 4.0 percent of cosolvent, 2.0 to 5.0 percent of high boiling point solvent and the remnant amount of modified rosin. The cosolvent belongs to ester compound and the high boiling point solvent is the mixed solvent of one or more of the SAF-25, dioctyl sebacate, benzyl benzoate, dioctyl adipate. In the preparation of the welding wire, the key point is first to form the alloys of Sn with other metals, and then the alloys can be added to the tin for melting. The lead-free welding wire of the invention has good heat resistance without halogen, low flux spattering, low odor, non-corrosive flux residue, strong practical feature, good electrical insulation after being welded, crack-free flux residue and high reliability.

The present invention provides a flavoured product comprising four or more flavour materials having antimicrobial properties and selected from the group comprising nonanol, decanol, nonanal, decanal, amyl propionate, anethole synthetic, anisic aldehyde, basil oil, benzyl benzoate, benzyl butyrate, benzyl formate, camomile oil, cinnamic aldehyde, cis-3-hexenol, clove bud oil, damascone, ethyl acetoacetate, eucalyptus oil, ginger, isoamyl acetate, menthol laevo, methyl cinnamate, methyl salicylate, orange oil, rosemary oil, tarragon, Tea Tree oil, and peppermint oil; and one or more antimicrobial agents selected from the group comprising triclosan, pyrophosphates, zinc salts, cetylpyridinium chloride, parabens, stannous salts, sodium dodecyl sulphate, chlorhexidine, copper salts, strontium salts, peroxides and sanguinarine.

A non-addictive analgesic sustained-release drug delivery system, comprising: (1) a narcotic analgesic drug having a concentration of 1 mg / ml-160 mg / ml, the drug being selected from a group consisting of: a local analgesic drug, and the combination of the local analgesic drug and a nonsteroidal analgesic drug and / or an opioid analgesic drug; (2) a drug menstruum in a proportion of 1%-75% (v / v), the menstruum being selected from a group consisting of benzyl alcohol, ethanol, benzyl benzoate, ethyl lactate, and tetrahydrofurfuryl polyethylene glycol ether; and (3) a drug sustained-release formulation having a proportion of 25%-99% (v / v), the sustained-release formulation being selected from a group consisting of natural vegetable oil, synthetic lipid, artificially improved half-natural lipid and derivative thereof. Also disclosed are a preparation process and use of the sustained-release drug delivery system.

The invention discloses a preparation method which can improves the content of high added-value product benzaldehyde, benzyl alcohol and benzyl benzoate while not using an organic solvent and producing benzoic acid with high yield on the condition of not changing the existing benzoic acid production process and equipment. The invention has the advantages that through adjusting proportion of a catalyst, under the condition of best proportion of the catalyst, the conversion rate of the benzaldehyde is about 10 percent, the selectivity of the benzoic acid is 40 percent, the selectivity of the benzaldehyde is 30 percent, and the selectivity of the benzyl alcohol is 30 percent; and the content of the high added-value product benzaldehyde and benzyl alcohol are both high, and the catalyst can be repeatedly used, easy to regenerate, so that the production cost is lowered, and the economic benefits of benzoic acid production factories are greatly improved.

A flavour composition comprises at least 0.5% by weight of one or more of the following group A materials: cinnamic aldehyde, basil oil, tarragon, cis-3-hexenyl acetate, cis-3hexenol, orange oil, lime, citral, and damascone; and at least 3% by weight of one or more of the following group B materials: anethole synthetic, alcohol C10, eucalyptol, methyl salicylate, clove bud oil, carvone laevo, benzyl benzoate, thymol, benzaldehyde, benzyl formate, ethyl salicylate, eucalyptus oil, ionone alpha, iso amyl acetate, rosemary oil, cardamom oil, ginger, eugenol, camomile oil, spearmint, and peppermint. These materials have been identified as being capable of inhibiting the growth of Porphyromonas gingivalis or the protease (arg-gingipain) activity of Porphyromonas gingivalis, and so to possess hitherto unappreciated antimicrobial properties. The invention thus enables compositions to be defined comprising flavour materials that enhance the antimicrobial efficacy of known antimicrobial agents against micro-organisms or metabolic processes associated with gum diseases. The invention also provides a consumer product, particularly an oral or dental care product, including such a flavour composition; a method for reducing or preventing gum disease; and use of the flavour compositions for reducing or preventing gum disease.

The invention relates to the technical field of daily chemical fabric washing products, in particular to a detergent composition with a mite control function. As benzyl benzoate and methyl dihydrojasmonate with certain content are added in the detergent composition, the detergent has the effect of inhibiting mites from invading washed textile; and moreover, as appropriate amount of surfactant anddetergent assistant are cooperated with benzyl benzoate and methyl dihydrojasmonate, the coordination effect among components is increased, and as a result, the detergent composition has a better mitecontrol effect.

Sympathetic nerve-stimulating fragrant compositions with weight-loss effects, characterized by containing one or more selected from among fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and olibanum, or one or more from among limonene, pinene, myrcene and benzyl benzoate as the active ingredients in the oils, and preferably also containing caffeine.

The invention discloses a preparation method of functional non-woven fabric, and functional non-woven fabric prepared via the preparation method. The functional non-woven fabric is prepared via loading 0.1 to 0.3 parts of nanoscale bamboo charcoal powder, 0.2 to 0.3 part of polydimethylsiloxane diquaternary ammonium, 0.3 to 0.5 part of modified tea polyphenol powder, 0.1 to 0.3 part of semen ziziphi spinosae, 0.2 to 0.4 part of polygala tenuifolia, 0.1 to 0.5 part of cortex albiziae, 0.1 to 0.2 part of dens draconis, 0.5 part of lavender, 0.3 to 0.5 part of sophora alopecuroide extract, 0.2 to 0.4 part of ammonium persulfate, 0.1 to 0.5 part of glycine betaine, 0.1 to 0.5 part of ethylene glycol phenyl ether, 0.2 part of benzyl benzoate, 1 part of glucose, 2 parts of tartaric acid, 1 part of xylitol, 3 parts of chitosan on a nano alginate fiber non-woven fabric base material containing phase change microcapsules.

The invention relates to osmanthus flower essence for water-based ink. The osmanthus flower essence for the water-based ink consists of the following ingredients in percentage by weight: 1 to 30 percent of osmanthus flower essence, 5 to 55 percent of composite modified oligosaccharide and deionized water, wherein the osmanthus flower essence consists of beta-ionone, dihydro-beta-ionone, linalool, alpha-jasminolene, alpha-amyl cinnamic aldehyde, isoamyl salicylate, benzyl salicylate, benzyl benzoate, galaxolide, citronellol, geraniol, cinnamyl alcohol, cognac oil, tetradecyl aldehyde, para-mentha-8-thiolone with the mass percent concentration being 1 percent, terpilenol, methyl anthranilate, osmanthus flower extracts and ethyl alcohol. The invention also provides a preparing method of the osmanthus flower essence for the water-based ink. The composite modified oligosaccharide is used as a wall material; the osmanthus flower essence is coated to form nanocapsule slow-release essence, so that the fragrance retention and the water solubility of the essence are improved; the preparing method is applicable to the perfuming of the water-based ink. The osmanthus flower essence for the water-based ink has the advantages that the fragrance is exquisite; the natural feeling is high; the fragrance retention is durable.

The invention provides a graphene-based antibacterial fabric preparation method which includes the steps: (1) fabric pretreatment: soaking a fabric by treatment liquid containing alkaline liquor and penetrating agents, and washing the fabric by water to reach neutral; (2) dyeing liquor preparation: diluting graphene oxide slurry by water, adding buffering solution and BB emulsion, uniformly mixingmixture to obtain dyeing liquor; (3) high-temperature dyeing: dyeing the fabric at high temperature by a temperature programming method according to a certain bath ratio; (4) drying and baking: drying the dyed fabric at the temperature of 110-150 DEG C, baking the dried fabric for 1-5 minutes at the temperature of 180-200 DEG C to obtain the antibacterial fabric based on the graphene. The BB emulsion is mixed emulsion of benzyl benzoate and polyoxyethylene castor oil. The antibacterial fabric preparation method based on the graphene is simple in process, easy to operate, the prepared textilefabric has excellent antibacterial and ultraviolet-proof functions, and a user instantly feels cool when contacting with the fabric.

The invention relates to a method and a device for producing benzyl benzoate. The device comprises a reaction and rectification tower and a rectification tower and is further connected with a benzaldehyde tower of a benzaldehyde device. The benzaldehyde tower is connected to an inlet of the rectification tower through the reaction and rectification tower, a gas outlet at the tower top of the rectification tower is connected to a gas treatment unit through an external condenser, a light fraction outlet and a heavy component outlet are respectively connected to a benzaldehyde distillation tower, and a product outlet is connected to a product tank through a product cooler. After reaction in the reaction and rectification tower, heavy component residual oil raw material at the bottom of the benzaldehyde tower enters the rectification tower to be rectified and separated; a product, namely benzyl formate, flows out of the middle part of the rectification tower and enters the product tank after heat exchange, gas components in the material flow out of the tower top, light fractions flow out of the upper part of the rectification tower, and heavy components flow out of the bottom of the tower. According to the method and the device, provided by the invention, byproducts produced by benzoic acid are fully utilized to produce the benzyl formate through the reaction and rectification process, the waste of resources is reduced and avoided, the economic benefits are improved, the emission of chemical pollutants is reduced, and the method and the device are further conductive to environmental protection.

The invention discloses a preparation method of soothing toner for makeup, which belongs to the field of cosmetic manufacture. The soothing toner is lotion with pH value close to 7 and slight alkalescence, has the functions of conditioning skin, supplying moisture to stratum corneum, softening cutin and removing aged cutin on skin caring, is used for assisting skin to accelerate removal of aged cells to play the effects of re-cleaning skin, moisturizing and nourishing and making skin fresher, softer and tender, and is suitable for oily, dry and combined skin with dark skin color. The soothing toner comprises the following materials: alkalescent mineral water, rose oil, jasmine oil, tea tree oil, lemon oil, honey, aloe juice, vitamin C, vitamin E, tricyclodecenyl acetate, isoeugenol, p-tolyl phenylacetate, glycerol and benzyl benzoate, and is applicable to skin caring.

The invention discloses cat-driving essence as well as a preparation method and an application thereof. The cat-driving essence is obtained by adding a certain amount of bergamot oil, lemon oil, citral, linalyl acetate, sweet orange oil, terpilenol, terpinyl acetate, methyl ortho-aminobenzoate, decanal, geranyl acetate, lemonile, geranium oil, menthol, benzyl acetate, benzyl alcohol, linalool, dihydro jasmine with mass fraction of 10%, hydroxycitronellal, benzpyrole with mass fraction of 10%, dihydromyrcenol, methyl ionone, lyral, oil of daidai leaf, ylang ylang oil, gamma-delta-lacton, leaf alcohol, benzyl benzoate, benzyl propionate, methyl dihydrojasmonate, p-cresyl acetate, jasmonyl, phenylacetic acid, eugenol, myracaldehyde, absolute of jasmine, geraniol, cis-3-hexenyl benzoate, galaxolide with mass fraction of 50% and propylene glycol into a container in sequence, shaking uniformly, standing and ageing for two weeks. The cat-driving essence is remarkable in cat-driving effect.

The invention discloses a synthesis technology of 5-aryl-1H-pyrazolopyridine[4,3-d]pyrimidine-7(6H)-ketone. The synthesis technology comprises the following steps: mixing substituted aryl aldehyde with 1-methyl-3-propyl-4-amino pyrazole-5-formylamine, and contracting the mixture so as to obtain bisiminophosphorane benzyl benzoate; placing the bisiminophosphorane benzyl benzoate in a solvent, and under the common action of a ring forming agent and a pro-oxygenic agent, performing cyclization oxidization so as to obtain the 5-aryl-1H-pyrazolopyridine[4,3-d]pyrimidine-7(6H)-ketone. The synthesis technology disclosed by the invention is mild in reacting conditions, greatly higher in the conversion rate of a cyclization oxidation reaction, short in the reaction time, and less in the side reactions. The reaction can be carried out in different reactors in two steps, and can also be carried out in the same reactor. A stepwise synthesis method is favorable for the quality control of the bisiminophosphorane benzyl benzoate and the purification of products, the adoption of a one-step synthesis method simplifies the synthetizing working procedures and shortens the reaction time, and all the methods can effectively synthetize the 5-aryl-1H-pyrazolopyridine[4,3-d]pyrimidine-7(6H)-ketone. The used reagent is basically non-toxic or low-toxic, and besides, the synthesis technology is low in cost and is low in synthesis cost.

The invention discloses litchi essence which comprises the following components in percentage by weight: 65-95% of propylene glycol, 0.01-2% of dimethyl sulfide, 0.01-4.5% of ethyl acetate, 0.01-0.5% of alpha-terpilenol, 0.01-3% of d-limonene, 0.01-0.5% of ocimene, 0.01-1.5% of beta-caryophyllene, 0.01-0.5% of bisabolene, 0.01-2.3% of ethyl butyrate, 0.01-1.7% of linalool, 0.01-2.5% of beta-pinene, 0.01-4% of acetoin, 0.01-3% of phenethyl alcohol, 0.01-3% of nerol, 0.01-1.5% of geraniol, 0.01-1.8% of vanillyl alcohol, 0.01-0.2% of bitter orange flower oil, 0.01-0.5% of geranium oil, 0.01-1% of benzyl benzoate and 0.01-1% of 2-phenethyl phenylacetate.

The present invention provides a flavoured product comprising four or more flavour materials having antimicrobial properties and selected from the group comprising nonanol, decanol, nonanal, decanal, amyl propionate, anethole synthetic, anisic aldehyde, basil oil, benzyl benzoate, benzyl butyrate, benzyl formate, chamomile oil, cinnamic aldehyde, cis-3-hexenol, clove bud oil, damascone, ethyl acetoacetate, eucalyptus oil, ginger, isoamyl acetate, menthol laevo, methyl cinnamate, methyl salicylate, orange oil, rosemary oil, tarragon, Tea Tree oil, and peppermint oil: and one or more antimicrobial agents selected from the group comprising triclosan, pyrophosphates, zinc salts, cetylpyridinium chloride, parabens, stannous salts, sodium dodecyl sulphate, chlorhexidine, copper salts, strontium salts, peroxides and sanguinarine.

Provided is a superior, novel heterocyclic compound with improved solubility in oil such as sesame oil and benzyl benzoate, which has a broader treatment spectrum, causes less side effects, and is superior in tolerability and safety, and use thereof. A heterocyclic compound represented by the formula (I) wherein each symbol is as defined in the specification, or a salt thereof.

The invention relates to camellia essence for cigarette blast beads, blast beads prepared from the camellia essence and cigarettes, and belongs to the technical field of tobacco essence. The essence comprises a camellia extract, ethyl vanillin, an oak moss concrete, 2-methylbutyric acid, ethyl caprylate, 2-methylbutyrate-2-phenethyl ester, 2, 3, 5-trimethylpyrazine, sweet orange oil terpene, phenethyl acetate, caprolactone, phenylethyl alcohol, isoamyl acetate, germacrene D, linalool, acetic acid, 2-pentanol, palmitic acid, benzyl benzoate, ethyl isovalerate, damascenone, isovaleric acid, acetophenone, ethyl caprate, and the like. The blast beads can improve the cigarette smoking comfort, improve the cigarette smoking sweetness, reduce the stabbing and choking feeling in cigarette smoke and reduce the stabbing feeling of the tongue surface, the flower fragrance and the cigarette fragrance are good in coordination, and the blast beads have high application value and popularization significance.

The invention discloses a preparation method which can improves the content of high added-value product benzaldehyde, benzyl alcohol and benzyl benzoate while not using an organic solvent and producing benzoic acid with high yield on the condition of not changing the existing benzoic acid production process and equipment. The invention has the advantages that through adjusting proportion of a catalyst, under the condition of best proportion of the catalyst, the conversion rate of the benzaldehyde is about 10 percent, the selectivity of the benzoic acid is 40 percent, the selectivity of the benzaldehyde is 30 percent, and the selectivity of the benzyl alcohol is 30 percent; and the content of the high added-value product benzaldehyde and benzyl alcohol are both high, and the catalyst can be repeatedly used, easy to regenerate, so that the production cost is lowered, and the economic benefits of benzoic acid production factories are greatly improved.

The invention discloses a water-proof, anti-seepage and high-temperature-resistant electrical insulation tape for telecommunication, and relates to the technical field of communication materials. Thewaterproof, anti-seepage and high-temperature-resistant electrical insulation tape for telecommunication comprises the following components: nano zinc powder, polyvinyl alcohol, tricresyl phosphate, polystyrene plastic scraps, hydrogen peroxide, simethicone, a penetration-resistant agent, an oxidizing curing agent, roasted kaolin, ethyl alcohol, polyvinyl chloride, polystyrene, algin, borax, a softening agent, linalool, nanometer titania, arbutin powder, myristic acid zinc, benzyl benzoate, citrate, an inert inhibitor and activated alumina spheres. The tape has efficient waterproof, anti-seepage and high temperature resistant functions; the used materials are safe, and conveniently and easily obtained; the safety of the materials in use is improved; the service life is long; and the stability is high.

The invention belongs to the field of essence for cigarette, and particularly relates to tea essence of durable cigarette blast balls. The essence is prepared from 15 to 20 parts of tea extracts, 5 to10 parts of tea high-boiling-point essential oil, 1 to 3 parts of benzyl benzoate and 70 to 80 parts of medium chain triglyceride in parts by weight. The essence has the beneficial effects that the tea essence for cigarette contains tea extracts and high-boiling-point essential oil; through the enzymolysis effect of beta-glucosidase, the terpene alcohol high-boiling-point fragrance ingredients inthe tea can be sufficiently extracted; the terpene alcohol high-boiling-point fragrance ingredients are combined with benzyl benzoate and medium chain triglyceride, so that the tea extracts (mainly volatile free-state fragrance ingredients) can well achieve the fragrance fixation; the blast balls prepared by the essence for cigarette have the advantages that after the blast balls are broken through being extruded, the fragrance release effect is good; customers can still feel the tea fragrance after smoking the whole cigarette.

The invention discloses a disinfection solution of a summer sleeping mat. The disinfection solution consists of the following components in percentage by mass: 50-55% of alcohol, 1.5-2% of didecyl dimethyl ammonium chloride, 2-2.5% of benzyl benzoate, 2-3% of AEO-9, 1-2% of benzalkonium chloride, 0.4-0.5% of menthol, 0.1-0.2% of EDTA-2NA, 0.1-0.15% of essence and the balance of water, wherein the total mass percentage is 100%. The disinfection solution disclosed by the invention is simple in production process, easily-available in raw material, low in cost, strong in sterilization capability and complete in mite removal, and is particularly suitable for mite removal of the summer sleeping mat.

The invention discloses a method for preparing benzyl benzoate by oxidizing dibenzyl ether, which comprises steps as follows: A, oxidization; B, rectification and refining; C, acid-alkali neutralization; D, freezing crystallization; and E, centrifugal separation. According to the method disclosed by the invention, by-product dibenzyl ether produced by benzyl alcohol preparation is used as a raw material, so that the defects of other benzyl benzoate preparation methods are well solved; the preparation cost is low, the product quality is good, and no pollution is caused; and therefore, the preparation method disclosed by the invention is the method of preparing high-quality benzyl benzoate by low cost.

The invention relates to incense essence for burning. The incense essence is prepared from 6-7.5 parts of sandel mysore core, 0.05-0.2 part of ebanol, 8-10 parts of sandalwood 210, 20-25 parts of bangalol radjanol, 22-28 parts of sandalwood 803, 0.5-1.5 parts of methyl cedryl ether, 3-6 parts of timberol, 0.5-2 parts of leopard ambergris and 20-38 parts of benzyl benzoate. The fragrances of all the components of the incense essence for burning not only have unique characteristics, but also are fused together, and good compatibility and sense of harmony are achieved; the incense essence, prepared by mixing the components, for burning is natural, thick, pure and pleasant in fragrance; furthermore, by means of the cooperation effect of all the components, the fragrance is lasting.

The invention relates to a ginkgo-damole medicinal composition for injection, which can be used for preventing and treating the coronary heart disease and the thromboembolic diseases and a preparation method of the ginkgo-damole medicinal composition. The composition consists of ginkgo leaf extract, dipyridamole, soybean oil, phospholipid, benzyl benzoate and glycerin. The use of the benzyl benzoate is beneficial to the quality of the composition. The composition disclosed by the invention solves the problems of low solubility and instability of active ingredients of ginkgo-damole. The composition has a certain slow release and targeting properties, so that the probability and the risk that the medicament has adverse reaction can be reduced and the safety and the effectiveness of the clinical medicine application are improved.

The invention relates to a spice module formula for improving aroma characteristics of scorched sweet flavor myrcia group, the module is composed of, by weight, jujube extracts 1-5%, malt extracts 1.5-6%, apricot extracts 0.3-4%, plum extracts 0.5-3.5%, benzyl benzoate 0-1.5%, limette oil 0.1-3%, isoamyl phenylacetate 0.2- 4% and ethyl levulinate 0.1-2%, and the balance is solvent. The addition ofthe spice module formula can significantly improve the aroma characteristics of cigarettes, the fullness and the thick feeling are improved, and the miscellaneous gas is also greatly reduced, which provides great significance for improving the quality of the scorched sweet cigarettes.

The invention belongs to the field of pharmacy, and mainly relates to a non-addiction local anesthesia analgesic sustained-release drug delivery system and a method for preparing the same. The sustained-release drug delivery system comprises analgesics, solvents and sustained-release preparations. The analgesics are compositions of bupivacaine free alkali or bupivacaine salts and morphine; the solvents are one or two of ethyl alcohol, benzyl alcohol, benzyl benzoate, ethyl lactate and tetrahydrofuran polyglycol ether; the sustained-release preparations are one or two of soybean oil, ethyl oleate and castor oil. The non-addiction local anesthesia analgesic sustained-release drug delivery system and the method have the advantages that the non-addiction local anesthesia analgesic sustained-release drug delivery system is free of addiction, long in analgesic duration time and low in toxicity, obvious analgesic effects can be realized, and only few side effects can be realized; the non-addiction local anesthesia analgesic sustained-release drug delivery system is free of human tissue irritation and influence on healing of postoperative wound, and obvious local anesthesia analgesic treatment effects can be realized for the postoperative wound.

A progesterone emulsion type injection comprises progesterone, an oily solvent and water for injection, wherein the oily solvent is a mixture of oil for injection and benzyl benzoate, and the mass ratio of the oil for injection to the benzyl benzoate is 1:5 to 5:1. In the progesterone emulsion type injection provided by the invention, the progesterone has excellent solubility, so that the use amount of the oily solvent can be greatly reduced, and adverse reactions caused by oil needle injection can be greatly alleviated; and at the same time, the progesterone emulsion type injection provided by the invention has a high drug encapsulation rate, and a drug is not precipitated out after long-term storage.

The invention relates to an ophthalmic depot formulation containing benzyl benzoate and / or benzyl alcohol and polyethylene glycol and / or dimethylsulfoxide wherein the volume ratio of benzyl benzoate and / or benzyl alcohol and polyethylene glycol and / or dimethylsulfoxide in the ophthalmic depot formulation is 75:25-25:75, and the ophthalmic depot formulation contains a total of 50% (w / w) or more of benzyl benzoate and / or benzyl alcohol and polyethylene glycol and / or dimethylsulfoxide.