The application belongs to the field of pharmaceutical
chemical industry, and particularly relates to a preparation method of
Zolpidem. The method uses 2-bromo-N,N-
dimethylacetamide as a starting material, and the starting material is activated by
iodine /
zinc, and then subjected to a
coupling reaction with 3-bromo-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]
pyridine to obtain the target product. The method can avoid the use of dangerous chemical reagents, and has high product yield and purity, and is suitable for industrial production.