8 results about "Zolpidem" patented technology

The invention discloses application of a metabonomics marker combination in preparation of a product for identifying benign and malignant lung ground glass nodules. The metabonomics marker combination comprises the following 11 metabonomics markers: 5 '-S-methyl-5'-thioadenosine, 5 '-S-methyl-4'-thioadenosine, 5 '-S-methyl-4'-thioadenosine, 5 '-S-methyl-4'-thioadenosine, 5 '-S-methyl-4'- And gamma-glutamylglutamic acid; the component A is N-stearoyl-D-red sphingosine; sphingosine; palmitoyl ethanolamide; 2-(4-(diethylamino) butyl-2-alkyne-1-yl) isoindene-1, 3-diketone is used as a raw material; vesenadine; zolpidem; the preparation method comprises the following steps: adding 4-hydroxyl-3-(2 '-hydroxyl-1, 1'-biphenyl-4-yl)-6-oxo-6, 7-dihydrothieno [2, 3-b] pyridine-5-formonitrile into a reaction kettle, and stirring for 20-30 minutes; and D-erythro-sphingosine; the invention relates to 3-methylpyrrole-2, 4-dicarboxylic acid. According to the invention, 11 specific metabolic markers closely related to benign and malignant lung ground glass nodules are found, the AUC value of a diagnosis model constructed on the basis of the 11 metabolic markers is up to 0.888, and the diagnosis model has extremely high identification accuracy and specificity.

The application belongs to the technical field of medicine synthesis, and particularly relates to a preparation method of Zolpidem. The method uses 2-(6-methyl-2-(p-tolyl) imidazo[1,2-a]pyridine-3-yl) acetaldehyde as a reaction raw material, and prepares Zolpidem through catalytic oxidation reaction with N,N-dimethylformamide. The preparation method has the advantages of safe operation, simplicity, environmental friendliness, short reaction steps, and high yield and purity of the prepared Zolpidem.

1. Name of the product in this design: Packaging Box (Double-Zolpidem Suppository). 2. Intended use of this design: for pharmaceutical packaging. 3. The key design features of this product are the combination of shape and pattern. 4. The image or photograph that best illustrates the design's key features: the front view.

The present application relates to the technical field of crystal form drug molecules, and specifically provides a zolpidem co-crystal and a preparation method thereof.The present application specifically provides a co-crystal of zolpidem and succinic acid with a molar ratio of 2:1 and a co-crystal of zolpidem and glutaric acid with a molar ratio of 2:1.The preparation method of the zolpidem co-crystal provided by the present application is simple in operation, the prepared crystal has high purity, the zolpidem co-crystal provided by the present application has good chemical stability and good solubility.

The invention relates to zalpyrazolam, in particular to a preparation method of zalpyrazolam. The method comprises the following steps: carrying out nucleophilic substitution reaction on a compound A and a compound B to obtain a compound C; performing oxidation reaction on the compound C to obtain a compound D; performing reduction reaction on the compound D to obtain a compound E; carrying out nucleophilic substitution reaction on the compound E and a compound F to obtain a compound G, and carrying out ring closing reaction on the compound G and a compound H to obtain a compound I; the compound I is subjected to a thio reaction to obtain a compound J; performing ring closing reaction on the compound J and a compound K to obtain a compound L; performing demethylation reaction on the compound L to obtain a compound M; performing chlorination reaction on the compound M to obtain a compound N (zalpyrazolam); the invention provides a brand new preparation method of zalpyrazolam, which has the advantages of simple route, cheap and easily available raw materials, mild conditions and high reaction yield, and greatly reduces the production cost of zalpyrazolam.

The application belongs to the technical field of crystal form drug molecules, and relates to zolpidem salts, and a preparation method and application thereof. The application specifically provides zolpidem oxalate, zolpidem fumarate, zolpidem malonate and zolpidem-5-sulfosalicylate methanol compound. The method for preparing the zolpidem salt provided by the application is simple to operate, and the prepared crystal has high purity. The zolpidem salt provided by the application has good chemical stability and good solubility.

The invention discloses an acacetin and zolpidem eutectic crystal, a preparation method, a composition and application thereof, and belongs to the technical field of medicines. Specifically, the invention discloses an eutectic substance formed by acacetin and zolpidem, and the molecular formula of the eutectic substance is (C16H12O5). (C19H21N3O), the invention relates to a preparation method of a cocrystal of acacetin and zolpidem. The acacetin and zolpidem eutectic crystal is used as an active ingredient of a medicine and is applied to preparation of medicines for resisting oxidation, resisting inflammation, resisting viruses, resisting tumors, resisting rheumatism, easing pain, protecting the liver, regulating immunity, treating osteoporosis and treating cardiovascular and cerebrovascular diseases.

The application belongs to the field of pharmaceutical chemical industry, and particularly relates to a preparation method of Zolpidem. The method uses 2-bromo-N,N-dimethylacetamide as a starting material, and the starting material is activated by iodine / zinc, and then subjected to a coupling reaction with 3-bromo-6-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine to obtain the target product. The method can avoid the use of dangerous chemical reagents, and has high product yield and purity, and is suitable for industrial production.