42results about How to "Regulated release" patented technology

The invention discloses a preparation method of a multi-growth-factor slow release coating of a titanium and titanium alloy surface. According to the method, a plurality of layers of coatings containing nanoparticles of growth factors are prepared on the titanium surface by taking the nanoparticles as a growth factor carrier and charged high molecular thin films as a medium. The nanoparticles included in the coating are prepared by mixing polycation solution containing dopamine of certain concentration with polyanion solution containing the growth factors. The nanoparticles have good dispersibility, can protect the activity of the growth factors and are easy to fix on the surface of a material. By controlling the electric property of the nanoparticles and the high molecular thin films, nanoparticles carrying with different factors are embedded between the high molecular thin films. By adjusting the loading quantity and the loading sequence of different nanoparticles and the thickness of the coatings, effective control over release speed, release quantity and release sequence of the various growth factors can be realized.

The invention provides a multifunctional ordered medicine release medical coating film for acute trauma and a preparation method thereof. The multifunctional ordered medicine release medical coating film for acute trauma is characterized by comprising fiber formed through coaxial static spinning; the fiber comprises a bleeding stopping and pain relieving layer and an anti-bacterial healing promotion layer arranged in the bleeding stopping and pain relieving layer; the bleeding stopping and pain relieving layer comprises one or several kinds of materials from high molecular polymers, bleeding stopping factors dispersed into the high molecular polymers and pain relieving medicine; the anti-bacterial healing promotion layer comprises high molecular polymers, antibacterial medicine dispersed in the natural high molecular polymers, and mesoporous SiO2 particles loaded with bioactive factors. The preparation method is simple; the materials can be easily obtained; the treatment and the use are safe; the prepared multifunctional ordered medicine release medical coating film can be matched with different stages of the wound healing; the medicine or active substances required for wound healing can be timely and orderly released.

The invention discloses an injectable type self-healing hemostatic material as well as a preparation method and application thereof. The injectable type self-healing hemostatic material is obtained by self-assembling macromolecular microgel particles with surface charges through electrostatic interaction between the particles or the particles and macromolecules. The electrostatic action between the microgel particles or the particles and the macromolecules is physical crosslinking and has reversibility, so the hemostatic material prepared by the method has high injectability, self-healing capability and high mechanical strength, does not need to introduce chemical crosslinking reaction in the injection and solidification process, is different from chemical macromolecules, does not introduce a micromolecular crosslinking agent, has high biocompatibility, can be degraded and absorbed, does not have toxic or side effects, has high safety and makes wide application in the field of biomedicine possible.

The invention discloses a porous composite biological material containing multiple active ions and a preparation method thereof, relating to the technical filed of production of medical materials. The porous composite biological material is a triple compound containing multiple active ions and calcium phosphate-silicate-calcium carbonate, and is composed of a porous ceramic structure main body containing active ions A and calcium phosphate-calcium carbonate and a phosphate-silicate cement coating, wherein both phosphate and silicate in the phosphate-silicate cement coating contain active ions B and calcium; and the phosphate-silicate cement coating accounts for 5-60% (mass percent) of the micropore structure main body. According to the invention, the exquisite three-dimensional intercommunication micropore structure of cuttlebone having extremely high porosity is kept, has excellent bone conductibility and favorable degradability, and can be subjected to stepped degradation; the release of the active ions and beneficial elements can be regulated and controlled; and the overall degradation rate of the material can be regulated according to different new bone formation requirements.

The invention provides a tissue engineering scaffold, a preparation method thereof and a 3D printing ink capable of being directly biologically mineralized. The tissue engineering scaffold comprises ahigh molecular hollow tubular structure, and the surface of the scaffold is uniformly covered with a nano-hydroxyapatite layer with controllable thickness. The tissue engineering scaffold can be widely applied to filling and reconstruction of bone tissues. The preparation method of the tissue engineering scaffold is carried out by virtue of shell-core coaxial spray head 3D printing under bio-safety conditions, and a three-dimensional scaffold stacked by hollow pipes can be efficiently prepared. The scaffold comprises an open macroporous structure and a controllable hollow pipe structure. Compared with straight-through hole scaffolds prepared by virtue of an existing template method, the tissue engineering scaffold has two types of hole structures, and the tubular orientation is controllable. The uniformly-distributed and thickness-controllable nano-hydroxyapatite layer is rapidly mineralized on the surface of a high molecular hollow tubular scaffold, so that the adhesion and multiplication of cells and the osteogenic differentiation can be remarkably improved.

The invention relates to a near-infrared light response photodynamic drug controlled release system and a preparation method thereof. The near-infrared light response photodynamic drug controlled release system and the preparation method thereof can effectively solve the problems that an existing controlled release system is poor in near-infrared response, high in toxic and side effects and poor in controllability. The near-infrared light response photodynamic drug controlled release system and the preparation method thereof is characterized in that succinic acid monoester of a light trigger compound is synthesized and is grafted to biodegradable carboxymethyl chitosan (CMCS) with good biocompatibility so as to form an amphiphilic conjugate, the amphiphilic conjugate is dissolved in neutral or weakly-alkaline deionized water, then an organic solution containing a hydrophobic photodynamic is added, uniform mixing is carried out, and ultrasonic self-assembly is carried out so as to obtain the near-infrared light response photodynamic drug controlled release system. The controlled release system reaches a target part of a human body through intravenous injection or other approaches and can respond to in-vitro near-infrared light stimulation to accelerate release of the photodynamic agent; and the release of the photodynamic agent can be regulated and controlled by adjusting the action time and the intensity of near-infrared light, and the controlled release system is used for photodynamic therapy of cancers.

The invention belongs to the field of pharmaceutical preparations and discloses a piribedil sustained-release tablet and a preparation method thereof. The sustained-release tablet is prepared from, by mass, 10%-40% of piribedil, 50%-80% of a hydrophobic framework material, 1%-5% of an adhesive and 0.5%-5% of a lubricating agent, wherein the hydrophobic framework material is a mixture of microcrystalline cellulose, glyceride, wax and a melting promotion agent, glyceride refers to one or two of glycerin monostearate or glyceryl palmitostearate, and wax refers to one or two of white beeswax or palm wax. The sustained-release tablet which comprises the hydrophobic framework material and the like has advantages of high controllability in medicine release, applicability to treatment of Parkinson's disease, simple process and benefits to production expansion.

The invention discloses a chitosan coating material with adjustable slow release performance and a preparation method thereof. The method comprises the following steps: modifying the chitosan by the alkyl ketene dimers to obtain a hydrophobic chitosan slow release material, reacting the alkyl ketene dimers with active hydroxyl and amino in the chitosan chain and introducing a long-chain hydrophobic gene in the chitosan chain; and mixing a terminated isocyanate cross-linking agent and a modified chitosan derivative to prepare the slow release coating solution. The grafting ratio of the chitosan is different, the hydrophobic ability of the chitosan derivative is different, and the cross-linking degree of the material can be changed according to the dosage of the cross-linking agent, so that the slow release performance of the coating material can be adjusted and the purpose for adapting to different crop growth cycles can be reached.

The invention relates to the field of surface modification of biological materials and specifically relates to an organic inorganic compound flower-like coating and a preparation method thereof. The preparation method comprises the following steps: soaking a metal substrate in a mixed solution of zinc phosphate solution and biological active organic molecular solution, and then performing liquid deposition for 2.5-4 hours at 36-38 DEG C. A liquid deposition method is adopted for preparing a compound coating on the metal substrate after the zinc phosphate solution and the biological active organic molecular solution are mixed, and on the basis of a chemical coordination principle, organic molecules and inorganic components are compounded and hybridized so as to form a special flower-like topological structure, so that the activity and stability of organic molecules are guaranteed, and meanwhile, the biological activity and biocompatibility of coating are promoted under the synergistic effect of inorganic components, organic active molecules and special flower-like structure, the deposition of active calcium phosphate can be induced and the growth, proliferation and adhesion of osteoblasts can be boosted. Besides, the corrosion degradation rate of zinc substrate can be effectively restrained and the release of zinc ions can be regulated and controlled.

The present invention belongs to the technical field of slow-release fertilizer coating material preparation, and relates to an environmental protection type slow-release fertilizer coating material preparation method, which comprises: taking a natural skim rubber, pre-treating, taking manihot esculenta starch, and modifying to obtain modified starch for spare; and adding the modified starch to the natural skim rubber, rapidly and uniformly mixing, adding a cross-linking agent and a short chain starch activator, and carrying out a reaction to obtain a starch grafted and modified natural skim rubber emulsion, ie., the environmental protection type slow-release fertilizer coating material. According to the present invention, the pre-activation short chain starch emission grafting technology is used, the process is simple, and the reaction is stable; and according to the obtained slow-release fertilizer coating material, the slow-release property of the fertilizer can be regulated, the coating has good toughness and good soil burying degradation property, the high added value utilization of the natural skim rubber is easily achieved, the natural environment protection and the l petrochemical resource saving are easily achieved, and the traditional agriculture is easily converted into the green organic agriculture.

The invention relates to development and application of a cryptotanshinone sustained release solid dispersion pellet and belongs to the field of medicines. Cryptotanshinone is a salviae miltiorrhizae fat soluble active ingredient, and researches show that cryptotanshinone has obvious anti-inflammatory and antioxidant activities and has an obvious subsidiary function in salviae miltiorrhizae angina treatment, so that the cryptotanshinone sustained release solid dispersion pellet is designed and prepared according to chronopharmacology principles and is applied to treatment on angina. Firstly an appropriate hydrophilic and hydrophobic polymer material is selected as a dispersion carrier, then an appropriate simple and convenient method is utilized for preparing the cryptotanshinone sustained release solid dispersion pellet, and medicine release is regulated by regulating the carrier ratio, so that the medicine release is consistent with attack frequency of the angina.

The invention discloses a tumor-immunity-enhancement nutrient food and a preparation method thereof. The tumor-immunity-enhancement nutrient food is prepared from, by weight, 5-25 parts of high-quality protein, 5-25 parts of dietary fiber immune nutrients, 29-76 parts of amino acid immune nutrients, 0-2 parts of probiotic immune nutrients, 4-15 parts of an acidity regulator, 3-10 parts of L-malicacid, 0-3 parts of a sweetening agent, 0-2 parts of essence, 0-1 part of a compound nutrition enhancer and 5-15 parts of carbohydrate. The preparation method of the tumor-immunity-enhancement nutrientfood comprises the steps of a) weighing; b) smashing; c) premixing; d) total mixing; e) subpackaging. The food has high target performance, by adding the immune nutrient substances, the nutrient conditions of a tumor patient can be improved, the body immunity and the inflammatory reaction can be regulated, and therefore the effects are achieved that infection and non-infection complications are reduced, the hospitalization time is shortened, and the treatment effect is improved.

The invention relates to the field of single crystal preparation, in particular to a method for preparing a single crystal or an amorphous substance by using an aqueous solution, which is suitable forpreparing and culturing any water-soluble molecular single crystal or amorphous substance. The method comprises the following steps: (a1) preparing an aqueous solution of a quasi-crystalline substance; (a2) freezing the water solution of the quasi-crystalline substance in the step (a1), and optionally aging the water solution to prepare a mono-crystal or amorphous substance-ice mixed system containing the quasi-crystalline substance; optionally, (a3) separating the monocrystal or amorphous substance-ice mixed system of the quasi-crystalline substance in the step (a2) to obtain the monocrystalor amorphous substance of the quasi-crystalline substance. The method aims at the defects that the molecular nucleation and aggregation speed is difficult to control and the like in the process of culturing the single crystal or amorphous substance by the traditional method; the invention provides the method for inducing nucleation and crystallization of solute molecules by freezing an aqueous solution for the first time, so that the solute molecule single crystal or amorphous substance is rapidly and effectively prepared.

The invention belongs to the field of pharmaceutic preparation, and discloses a lurasidone hydrochloride sustained release tablet and a preparing method thereof. The release tablet is prepared from, by mass, 5-15% of lurasidone hydrochloride, 50-90% of hydrophobic skeleton material, 1-5% of adhesive and 0.5-5% of lubricant. The lurasidone hydrochloride sustained release tablet comprises the hydrophobic skeleton material and the like, medicine release can be regulated well, the lurasidone hydrochloride sustained release tablet can be used for treating osteoarthritis, the process is simple, andexpanded production is facilitated.

The invention relates to the technical field of preparation of single crystals or amorphous substances, in particular to a method for preparing a quasi-crystalline substance single crystal or an amorphous substance. According to the method, nucleation and crystallization of the quasi-crystalline substance are induced through solution freezing, crystallization of the dissolved quasi-crystalline substance is achieved in the freezing process of the solution, and single crystals or amorphous substances of the quasi-crystalline substance are rapidly and effectively prepared. Meanwhile, the problemthat single crystals or amorphous substances of molecules are difficult to crystallize in traditional pseudo-crystalline substance single crystal preparation and culture is solved. According to the method, the acquisition of the pseudo-crystalline substance single crystal or amorphous substance under extremely low solution concentration is realized for the first time; and the problems of difficultcontrol of single crystal formation, easy formation of polycrystals and twin crystals and the like caused by too fast aggregation of quasi-crystalline substances under high concentration are also solved. The method is wide in application range and suitable for existing quasi-crystalline substances.

The invention belongs to the field of medicine preparations and discloses dronedarone hydrochloride slow-release tablets and a preparation method thereof. The slow-release tablets are prepared from, in percentage by mass, 10%-35% of dronedarone hydrochloride, 50%-90% of a hydrophobic framework material, 1%-5% of a binder and 0.5%-5% of a lubricant. The slow-release tables are prepared from the hydrophobic framework material and the like, medicine release can be well controlled, the process is simple, and expanded production is facilitated.