33 results about "Bone neoplasm" patented technology

The invention relates to a method for preparing a medical titanium material with high anti-cancer and antibacterial properties. The method comprises the following steps of: firstly, generating highly regular and ordered titanium dioxide nanotube arrays on the surface of the titanium material by an anodic oxidation method; secondly, generating selenium nanoparticles in titanium dioxide nanotubes in situ by an electrochemical deposition method; and finally, modifying multi-layer chitosan on the surface of the titanium material by a spin-coating method to obtain the medical titanium material with high anti-cancer and antibacterial properties. The method is easy to operate and low in cost, special equipment is not needed, and tests prove that the obtained product can inhibit the growth of bone tumor cells for a long time and promote the growth of normal osteoblasts simultaneously and has high antibacterial property.

The invention discloses a device used for preventing tumor spreading after bone neoplasms biopsy, belonging to the technological field of medical instruments, which comprises a plugging body used for plugging biopsy needle passage after biopsy is made; wherein, the plugging body is made of water absorbing expandable material; a plurality of screw threads are arranged at outer surface; one end of the plugging body is plugging end; the maximum diameter of the plugging end is smaller than the diameter of the biopsy needle passage; the other end of the plugging body is an operation end; a jack or an inserting handle grafting the operation wrench along axial direction of the plugging body is arranged on the operation end; maximum diameter of the operation end is bigger than the diameter of the biopsy needle passage; central section of the plugging body is inner concave type connection rod; smooth transition is adopted between the connection rod and the plugging end and the operation end; an anti-cancer drug layer is coated on the plugging end and is used for plugging the needle passage after biopsy is made. The device used for preventing tumor spreading has the advantages of preventing tumor from flowing out from the needle passage to the peripheral of puncturing site and from causing locally spreading and metastasizing, having simple structure and convenient operation.

The invention discloses a 3D printed magnetic biological ceramic scaffold which is prepared by taking biological ceramic powder, magnetic nano powder and a printing aid as main raw materials and sequentially carrying out 3D printing and degreasing sintering according to a three-dimensional scaffold model. According to the invention, a 3D printing technology is adopted, a magnetic nano material isfurther introduced into a biological ceramic material system by combining a liquid drying method and a two-step sintering method, so that the3D printed magnetic biological ceramic scaffold is endowedwith a magnetic effect which is not possessed by a traditional biological ceramic scaffold, the shape control and on-demand customization of the biological ceramic scaffold can be realized, and the biological ceramic scaffold is expected to be used for treating bone tumors and repairing bone defects; and the related preparation method is simple, wide in material source and suitable for popularization and application.

The invention discloses an adjustable bone tumor pathological specimen sampling fixator which comprises a workbench, a rotating shaft and a worm gear, a guide block is slidably mounted in a first sliding groove, a mounting frame is fixedly mounted at the top end of a supporting frame, and a first worm and a second worm are rotatably mounted between the mounting frame and the workbench. One end of the first worm and one end of the second worm are in transmission connection with the output end of a first motor and the output end of a second motor respectively, the two ends of the worm gear are in meshing transmission with the first worm and the second worm respectively, one end of the rotating shaft is fixedly installed in the worm gear, and the middle of the rotating shaft is rotationally connected with the guide block. A rotating frame is fixedly installed at the end, away from the worm gear, of the rotating shaft, and a movable clamping mechanism is installed in the rotating frame. Through meshing transmission cooperation of the first worm and the second worm with the worm gear, a clamped bone specimen can be lifted and rotated, and pathological specimen sampling can be conveniently carried out on different positions of the bone specimen.

The invention relates to the technical field of biomedical materials, in particular to a nano hydroxyapatite-coated porous stent and a preparation method and application thereof. The nano hydroxyapatite-coated porous stent provided herein includes a 3D printing porous titanium matrix material and nano hydroxyapatite coating; a microporous network TiO2 layer is formed on the surface of the 3D printing porous titanium matrix material; the nano hydroxyapatite coating is distributed evenly on the surface of the microporous network TiO2 layer. The invention also discloses a preparation method of the nano hydroxyapatite-coated porous stent and application of thereof in the preparation of bone neoplasm surgery defect repair materials. The nano hydroxyapatite-coated porous stent provided herein has good osteogenic effect, can inhibit the growth of local residual neoplasm cells and reduce recurrence, and has a good clinical application prospect.

The invention relates to the technical field of medical instruments, in particular to a bone tumor pathological tissues extractor with a cutting device. The extractor comprises an extractor body. The extractor body comprises a needle and a T-shaped handle. A top end of the needle is provided with a circular connecting block. The middle of the circular connecting block is provided with an inner tube holder. The needle is in a cavity form. A bottom end of the needle is a tip end which is provided with a circular hole. A suction inner tube is arranged in the needle. A bottom end orifice of the suction inner tube is connected with the circular hole. An upper end orifice of the suction inner tube is connected with the inner tube holder in the middle of the circular connecting block. The inner tube having a suction function is arranged in the needle, the cutting device is arranged on the lower portion of one side of the needle, and thus a tissue sample and sample liquid are acquired at a time. The extractor is simple in structure and convenient to operate, acquisition speed is high, work efficiency is high, and pain of a patient is greatly relieved.

The present invention provides methods of treating bone cancer, inducing differentiation of bone tumor cells, inhibiting bone tumor growth, inducing bone tumor regression or treating a hyperproliferative cell disorder by administering a pharmaceutically effective amount of a bone morphogenic protein or a nucleic acid encoding the bone morphogenic protein.

The invention discloses a minimally invasive channel bone tumor biopsy device, relates to the technical field of medical instruments, and solves the problems that the minimally invasive channel bone tumor biopsy device can only observe in one direction during use, a biopsy position cannot be positioned well, and the detection precision and biopsy quality will be affected. The minimally invasive channel bone tumor biopsy device comprises a mounting arm; the left arc of the mounting arm is slidably connected with a group of rotary mounting seats; the front end face of the left side of the mounting arm is fixedly connected with a set of angle adjusting driving pieces. the left portion and the lower portion of the inner side of the rotary mounting seats are respectively rotationally connected with a set of transmitting assemblies. According to the invention, imaging in two directions is achieved, meanwhile, by adjusting the installation angle of the rotary mounting seats, observation and imaging are conducted on the diseased part at different angles, the bone tumor biopsy position can be better determined, biopsy quality is guaranteed, detection accuracy is improved, unfolding and folding of the receiving assembly and the transmitting assembly can be achieved, and installation and use are convenient.

The invention discloses a bionic repair system for bone tumors and belongs to the field of computer-aided biomedical engineering and the system comprises a bone tumor image data input unit, a bone tissue region segmentation and surface morphology reconstruction unit, a bone tumor curved surface model unit, an integrated restoration prosthesis design unit and a bionic multi-cavity integrated restoration prosthesis output unit. Wherein the bone tissue region segmentation and surface morphology reconstruction unit comprises a supervoxel division subunit, a statistical machine learning segmentation subunit and a bone curved surface model reconstruction subunit; The integrated restoration prosthesis design unit comprises a bone loss form restoration subunit, an internal structure design subunitand an internal fixation prosthesis design subunit; According to the personalized and precise bone tumor repair system constructed by the invention, the automation of the design process is improved,and the complexity and inconvenience of the design process are reduced, so that the final repair prosthesis has good biocompatibility and mechanical property.

The invention relates to the technical field of biopsy devices, and concretely relates to a safe bone tumor biopsy device. The device comprises a mounting box, a rectangular fixing column is vertically arranged on the surface of the mounting box, a rectangular sliding groove is formed in one side of the rectangular fixing column, a cylindrical mounting bin is formed in the rectangular fixing column, a second spring is arranged in the cylindrical mounting bin, a fixing block is arranged on the other side of the rectangular fixing column and located on the lower middle portion, a locking block is slidably connected to the side face of the fixing block, and a sampling puncture needle body is movably connected to the side face of the rectangular fixing column. The position needing to be sampled is determined through a positioning table, the sampling puncture needle body is inserted into the body of a patient to sample, a pathological specimen can be obtained through a sampling area, a mixture of polyvinyl alcohol and hydrogel in the embolism storage bin is sprayed out from an instantaneous release ring through a micro water pump to timely block a needle hole, and the sampling punctureneedle is thin to avoid the problem of a large incision.

The invention discloses a device for preventing tumor spread after bone tumor biopsy. The device of the invention comprises an operation tube, a connecting tube, a blocking rod and a puncture tube, wherein the puncture tube is in threaded connection below the operation tube; the connecting tube is arranged between a blocking tube and the operation tube; and the puncture tube is used for puncturingtumor tissues, and a biopsy needle extends from the upper end of the blocking rod for sampling during biopsy. Since various parts are tightly connected and tumors can be blocked in all direction, thedevice for preventing tumor spread after bone tumor biopsy has a good anti-spread effect.

The invention discloses a bone tumor sampling and fixing device, which comprises a workbench; and two supporting columns are symmetrically arranged at the two ends of the surface of the top of the workbench. The top ends of the two supporting columns are connected with arc-shaped bases, the top end of each arc-shaped base is rotationally connected with a circular ring, a plurality of column casings are connected to the inner wall of each circular ring at equal intervals in a surrounding mode, a rack plate is connected to the inner wall of each column casing, and a steel column is arranged in each column casing. First driving motors are started to work at the same time; the first driving motors drive the first driving wheels to rotate; the first driving wheels drive first driven wheels to rotate through belts; the first driven wheels and the first driving wheels drive the worm wheels to rotate through worms, so that the worm wheels are engaged with the rack plates to rotate, the steel columns can move inwards until a bone to be sampled is completely fixed and clamped, and the situation that the bone is loosened in the process of sampling the bone to be sampled can be prevented.

A bone tumor biopsy puncture auxiliary device effectively increases the function of determining the knife feeding direction of a puncture needle and a scalpel and comprises a frame, a first rotating frame is arranged on the left side of the frame, a second rotating frame is arranged on the right side of the frame, a positioning box is arranged in the frame, and a positioning gooseneck pipe is arranged on the upper side of the positioning box. Fixed gooseneck pipes are arranged on the left side and the right side of a positioning gooseneck pipe, a fixing mechanism is arranged on the upper sides of the fixed gooseneck pipes, a positioning frame is arranged on the upper side of the positioning gooseneck pipe, a fixing frame is arranged on the front side of the positioning frame, a positioning disc is arranged in the fixing frame, a rotating positioning disc is arranged in the positioning disc, and a needle passage positioning disc is arranged in the rotating positioning disc. The fixing device is simple in structure and ingenious in conception, the aim of fixing limbs of a patient is effectively achieved through the design, the risk of local diffusion of cancer cells is reduced, the aim of positioning and fixing a needle passage is achieved, the function of protecting the puncture position of the patient is added, and the function of color contrast is added.

The invention relates to the technical field of specimen sampling, in particular to a bone tumor specimen sampler which comprises a device body. The device body comprises a first mounting frame, a supporting plate is fixedly mounted at the top of the first mounting frame, and an electric push rod is integrally mounted at the bottom end of the supporting plate. A second mounting frame is integrally mounted at the bottom end of the electric push rod, a motor is fixedly mounted on one side of the bottom end of the second mounting frame, a rotating rod is fixedly connected to the output end of the motor, the end, away from the motor, of the rotating rod is rotationally connected with the other side of the bottom end of the second mounting frame through a bearing, and a blade is fixedly mounted on the surface of the rotating rod. And a pressing assembly is fixedly mounted at the top end of the first mounting frame. By arranging the pressing assembly and controlling the lead screw, the pressing plate is tightly attached to the bone placed on the placing table, so that the pressing plate can press the bone, the stability during bone cutting is improved, the bone cutting quality is improved, and use is convenient.

The invention belongs to the field of tissue engineering scaffold materials and particularly relates to a near-infrared-light-sensitive ZIF8 functionalized gelatin nanofiber scaffold system and application thereof. The ZIF8 functionalized gelatin nanofiber scaffold system comprises a gelatin nanofiber scaffold and ZIF8 nanoparticles which are adsorbed onto the gelatin nanofiber scaffold and are subjected to calcination treatment. The invention finds that the ZIF8 nanoparticles have near-infrared-light-sensitive characteristics after being calcined, and can kill tumor cells under the action of near-infrared light stress. The ZIF8 functionalized gelatin nanofiber scaffold system disclosed by the invention is implanted into a defect part after bone tumor excision, and under the action of NIR, a temperature of a GF/ZIF8-phenamil scaffold is increased, so that residual tumor cells are killed. In practical application, in-situ transplantation can be adopted, the requirements of residual tumor cells and bone defect generation after tumor tissue excision can be met, and a new choice is provided for clinical bone tumor treatment.