Multifunctional ordered medicine release medical coating film for acute trauma and preparation method thereof

Abstract

The invention provides a multifunctional ordered medicine release medical coating film for acute trauma and a preparation method thereof. The multifunctional ordered medicine release medical coating film for acute trauma is characterized by comprising fiber formed through coaxial static spinning; the fiber comprises a bleeding stopping and pain relieving layer and an anti-bacterial healing promotion layer arranged in the bleeding stopping and pain relieving layer; the bleeding stopping and pain relieving layer comprises one or several kinds of materials from high molecular polymers, bleeding stopping factors dispersed into the high molecular polymers and pain relieving medicine; the anti-bacterial healing promotion layer comprises high molecular polymers, antibacterial medicine dispersed in the natural high molecular polymers, and mesoporous SiO2 particles loaded with bioactive factors. The preparation method is simple; the materials can be easily obtained; the treatment and the use are safe; the prepared multifunctional ordered medicine release medical coating film can be matched with different stages of the wound healing; the medicine or active substances required for wound healing can be timely and orderly released.

Description

technical field [0001] The invention relates to a multifunctional and ordered drug release medical film for acute wounds and a preparation method thereof, belonging to the field of biomedical materials. Background technique [0002] The skin is the largest and most important organ of the human body, which is of great significance for maintaining the stability of the internal environment of the human body and preventing the invasion of microorganisms. In daily life, the skin is injured by the outside world to form various traumas, including cuts, frictions and burns, etc. After various traumas cause large-area skin defects, it can lead to the disorder of the microenvironment in the human body, plus bacteria and other microorganisms Local or even systemic infection caused by the invasion of human body, resulting in complex and serious pathophysiological changes in the human body system, and severe cases even eventually lead to death. For wounds with damaged skin, medical dres...

AI Technical Summary

Problems solved by technology

[0004] Although the above-mentioned patents use the functionality of the carrier material itself or load a variety of active substances with different functions to stop bleeding, antibacterial or promote healing, the drugs and the active substances often act together at the initial stage of the wound, and the duration of the drug is limited. It can be released in a targeted and orderly manner according to different stages of wound healing, which not only reduces the utilization efficiency of drugs, but also makes it difficult to meet the needs of wound healing in different healing stages

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