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Porous composite biological material containing multiple active ions and preparation method thereof

A technology of composite biomaterials and active ions, which is applied in the field of porous composite biomaterials and its preparation, can solve the problems of complex production process and lack of osteoinductive activity, and achieve good conductivity and promote the effect of new bone formation

Inactive Publication Date: 2014-01-22
李亚屏
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to overcome the defects of existing bone graft substitute materials and bone tissue engineering scaffold materials lack of osteoinductive activity, better degradation characteristics, better porous structure and complicated production process, and provide a kind of Porous composite biomaterial, which maintains the exquisite three-dimensional interconnected microporous structure of cuttlefish bone with extremely high porosity, has excellent osteoconductivity, good degradability, and ideal porous structure. The material is in elemental composition, chemical composition and The microporous structure is closer to human bone minerals, and can be degraded stepwise. The release of active ions and beneficial elements can be adjusted, and the overall degradation rate of the material can be adjusted according to the requirements of different new bone formation.

Method used

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  • Porous composite biological material containing multiple active ions and preparation method thereof
  • Porous composite biological material containing multiple active ions and preparation method thereof
  • Porous composite biological material containing multiple active ions and preparation method thereof

Examples

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Effect test

Embodiment 1

[0058] Take 10 grams of cuttlebone porous bone ore support, 1.135 grams of manganese chloride, and 10 ml of water, prepare a solution to impregnate the cuttlefish bone porous bone ore support, and dry at 25 ° C for 72 hours; water 100 ml, phosphoric acid 9.6 ml, ammonium dihydrogen phosphate 2.4 g, glass Prepare the solution in the cup, add sodium hydroxide to adjust the pH to 4.0, completely immerse the cuttlebone porous bone ore support in the solution, and react under medium and low heat under microwave (frequency 2.45GHz, output power 270w) for 45 minutes, and dry at 60°C for 72 hour, get product 123101 (porous ceramic structure main body); get sodium metasilicate 1.2g, add water heating and dissolving into 5ml solution and tricalcium phosphate 0.8 gram, magnesium silicate 0.22 gram, strontium hydrogen phosphate 0.20 gram, potassium selenium polyphosphate Prepare 0.35g of slurry, divide 123101 into two equal parts, and take one part to spray with slurry; prepare 25ml of cal...

Embodiment 2

[0067] Cuttlebone porous bone mineral support 10 grams, zinc chloride 1.225 grams, water 10ml, prepared liquid impregnated cuttlefish bone porous bone mineral support, dried at 60°C for 2 hours; water 140ml, phosphoric acid 9.6ml, ammonium dihydrogen phosphate 2.4g, glass Phosphorus source solution was prepared internally, and potassium hydroxide solution was added to adjust the pH to 4.0. The cuttlebone porous bone ore support was completely immersed in the phosphorus source solution, and reacted under microwave at low heat (frequency 2.45GHz, output power 110w) for 180 minutes, and dried at 260°C After 6 hours, the product 123103 was obtained, and the product 123103 was divided into two parts; 3.2 g of sodium metasilicate was dissolved in water to form a 5.0 ml solution, and 0.8 g of tricalcium phosphate, 0.10 g of magnesium silicate, 0.125 g of strontium hydrogen phosphate, and 0.125 g of barium phosphate 0.2g, silver phosphate 0.1g, prepare a slurry, spray one of the produc...

Embodiment 3

[0078]Take 1.2g of sodium fluoride and 10ml of water to prepare a solution, impregnate cuttlebone porous bone mineral support (10g), and dry at 40°C for 8 hours; prepare a phosphorus source solution with 150ml of water, 6.0ml of phosphoric acid, and 0.6g of ammonium dihydrogen phosphate, and adjust the pH to 3. 0. Put the cuttlebone porous bone mineral support in the phosphorus source solution and react under microwave in a glass cup (frequency 2.45GHz, output power 420w) for 45 minutes; excellent color and good strength; dry at 100°C for 8 hours , to obtain the product 021501 (no ammonia smell); the product 021501 was divided into four equal parts, and one part of the 021501 product was taken, and 3.5ml of 28wt% potassium silicate solution, 0.9 grams of calcium hydrogen phosphate, 0.08 grams of strontium hydrogen phosphate, and 0.05 grams of magnesium phosphate were used , 0.32 grams of magnesium silicate, and 0.64 grams of calcium silicate to prepare a slurry, spray 21501 wit...

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Abstract

The invention discloses a porous composite biological material containing multiple active ions and a preparation method thereof, relating to the technical filed of production of medical materials. The porous composite biological material is a triple compound containing multiple active ions and calcium phosphate-silicate-calcium carbonate, and is composed of a porous ceramic structure main body containing active ions A and calcium phosphate-calcium carbonate and a phosphate-silicate cement coating, wherein both phosphate and silicate in the phosphate-silicate cement coating contain active ions B and calcium; and the phosphate-silicate cement coating accounts for 5-60% (mass percent) of the micropore structure main body. According to the invention, the exquisite three-dimensional intercommunication micropore structure of cuttlebone having extremely high porosity is kept, has excellent bone conductibility and favorable degradability, and can be subjected to stepped degradation; the release of the active ions and beneficial elements can be regulated and controlled; and the overall degradation rate of the material can be regulated according to different new bone formation requirements.

Description

[0001] The invention relates to the technical field of medical material production, in particular to a porous composite biological material containing multiple active ions and a preparation method. [0002] Background technique [0003] Human natural bone mineral is a compound containing elements such as Ca, P, C, Si, O, H, Zn, Sr, Mg, Mn, Cu, Fe, S, Al, Xi, K, Na, Cl and other trace elements thing. There is a wide range of isomorphic substitution behaviors in human bone mineralization engineering, so the mineral composition of human bone is very complex. Generally speaking, the main composition of human bone minerals is phosphate, followed by carbonate, and there is also a small amount of silicate. Simulating the composition and structure of human bone minerals is a strategic direction for the research and development of bone graft substitute materials or bone tissue engineering scaffolds. People hope that artificial bone can be degraded and implanted in the body to release...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/56A61L27/32A61L27/36A61L27/12
Inventor 李亚屏李桑彭兆祥李星汤亭亭熊汉峰李振波
Owner 李亚屏
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