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A preparation method of self-healing antibacterial microcapsule film based on host-guest interaction

A microcapsule, host-guest technology, which is applied to biocide-containing paints, coatings, anti-fouling/underwater coatings, etc., can solve the problems of reducing the service life of materials, reducing the cycle of food preservation, and re-injury of wounds, etc., to achieve Short time, good self-healing effect, easy operation

Active Publication Date: 2019-11-05
南通吉普森科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in existing antibacterial materials such as antibacterial paper, antibacterial plastic, antibacterial film, etc., although they have a hygienic self-cleaning function and can effectively prevent bacterial cross-infection, they are easily worn, reducing the service life of the material, thereby Lead to a reduction in food preservation cycle or secondary injury to the wound

Method used

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  • A preparation method of self-healing antibacterial microcapsule film based on host-guest interaction
  • A preparation method of self-healing antibacterial microcapsule film based on host-guest interaction

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preparation example Construction

[0030] A kind of preparation method of the self-repairing antimicrobial microcapsule film based on host-guest interaction of the present invention comprises the following steps:

[0031] Step 1, successfully modifying ferrocene (Fc) on polyacrylic acid (PAA) branched chain to form PAA-Fc polymer;

[0032] Step 2, the microcapsules are attached with different concentrations of chloramphenicol;

[0033] Step 3, immerse the base material in the PAA-Fc solution for a period of time, take it out and rinse it with ultrapure water;

[0034] Step 4, immerse in β-cyclodextrin branched polyethyleneimine (β-CD-PEI) solution for a period of time, take it out and rinse with ultrapure water;

[0035] Step 5, immersing in the drug-loaded microcapsule solution for a period of time;

[0036] Step three, step four and step five are repeated to self-assemble layer by layer on the surface of the substrate to form a self-repairing antibacterial microcapsule host-guest film material.

Embodiment 1

[0038] 1) Mix 100 mg EDC and 30 mg NHS to obtain mixed solution II; add 80 mg Fc and 160 mg PAA to mixed solution II, and react at room temperature for 12 hours to obtain PAA-Fc polymer.

[0039] 2) Add 4 mg of chloramphenicol into the microcapsule solution, and ultrasonically vibrate for 5 minutes to obtain a microcapsule-coated chloramphenicol solution.

[0040] 3) Soak the cleaned glass sheet in 4mg / mL PAA-Fc solution for 15min, rinse with water, then immerse in 4mg / mLβ-CD-PEI solution for 15min, then rinse with water; soak in drug-loaded microcapsule solution for 15min, the above The steps were repeated for 30 cycles to prepare a self-healing antibacterial microcapsule host-guest film.

[0041] figure 1 It is the antibacterial efficacy figure of the nano-microcapsule host-guest film prepared in embodiment 1 to Escherichia coli.

[0042] figure 2 It is the surface topography figure that embodiment 1 prepares nano-microcapsule host-guest film.

Embodiment 2

[0044] 1) Mix 113mg EDC and 32mg NHS to obtain a mixed solution II, add 90mg Fc and 175mg PAA into the mixed solution II, and react at room temperature for 16 hours to obtain a PAA-Fc polymer.

[0045] 2) Add 5 mg of chloramphenicol into the microcapsule solution, and ultrasonically vibrate for 6 minutes to obtain a microcapsule-coated chloramphenicol solution.

[0046] 3) Soak the cleaned glass piece in 5mg / mL PAA-Fc solution for 20min, rinse with water, then immerse in 5mg / mLβ-CD-PEI solution for 20min, rinse with water, soak in drug-loaded microcapsule solution for 20min, the above The steps were repeated for 25 cycles to prepare a self-healing antibacterial microcapsule host-guest film.

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Abstract

The invention discloses a preparation method of a self restoration antibacterial microcapsule film based on host-guest interaction. Firstly, ferrocene (Fc) is successfully modified onto a branch chainof polyacrylic acid (PAA) to form PAA-Fc polymers; then, micro capsules (PAH / PSS) are carried with different concentrations of chloromycetin; through a layer-by-layer self assembly technology, a substrate material is firstly soaked into a PAA-Fc solution for a period of time; after being taken out, the substrate material is flushed by ultrapure water and is then soaked into a beta-cyclodextrin branched polyethylenimine (beta-CD-PEI) solution for a period of time; after being taken out, the substrate material is flushed by ultrapure water and is then soaked into a medicine-carrying microcapsule for a period of time; a multilayer functional nanometer medicine-carrying microcapsule film is repeatedly assembled on the substrate for multiple times. The method has the advantages that convenience is realized; the cost is low; the prepared medicine-carrying microcapsule host-guest film has good self restoration functions, medicine release functions and antibacterial functions.

Description

technical field [0001] The invention relates to a method for preparing a self-repairing antibacterial microcapsule film based on host-guest interaction. Based on layer-by-layer self-assembly technology, a new driving force-host-guest interaction is developed, and microcapsules wrapped with chloramphenicol are introduced at the same time. The microcapsule host-guest film material not only has self-healing function, but also has excellent drug release function and antibacterial function, which can be applied to food packaging, fine cosmetics, drug transportation and other fields. Background technique [0002] Under suitable temperature and humidity conditions, microorganisms can grow and reproduce in large numbers. For example, food is contaminated by microorganisms during production, transportation, storage, etc., and thus oxidized and cannot be stored for a long time; for example, wounds are susceptible to microbial infection in the external environment, resulting in The wou...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C09D133/02C09D187/00C09D5/14C03C17/34
CPCC03C17/3405C09D5/14C09D133/02C09D187/005C08L87/005C08K9/12C08K9/10C08K5/32C08L33/02
Inventor 宣红云姚登兵葛丽芹
Owner 南通吉普森科技有限公司
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