The invention relates to a novel manufacturing process of an impeller. The novel manufacturing process is characterized by comprising the following specific process steps of S1, carrying out 3D printing on an impeller prototype; S2, manufacturing a casting system with a riser to form a module; S3, manufacturing a shell; S4, dewaxing and demolding treatment; and S5, carrying out casting molding. According to the novel manufacturing process of the impeller, compared with a traditional casting or forging method, the method has great advantages that a corresponding mold is needed when the castingor forging method is used, raw materials and time are wasted, the tedious procedures are omitted through the 3D printing technology, computer related software can be helped to directly generate the impeller, and any complex impeller can be quickly printed, so that the generation period is shortened, the cost is reduced, the advantage of greatly reducing the raw material loss in the research and development process is achieved, meanwhile, the impeller produced by using the process can greatly improve the overall shock absorption and noise reduction capabilities of a pumping set, actual production reference is provided for the rapid low-pressure investment casting production process of castings, and the feasibility of the process is verified.