Tissue engineering scaffold, preparation method thereof and 3D printing ink capable of being directly biologically mineralized

A 3D printing and biomineralization technology, applied in tissue regeneration, additive processing, prosthesis, etc., can solve the problems of poor tissue repair effect and non-biological fusion, and achieve increased adhesion, proliferation, and proliferation speed Improved effect

Inactive Publication Date: 2018-06-08
SHENZHEN UNIV
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  • Abstract
  • Description
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Problems solved by technology

However, at present, the tissue repair effect of large-scale stents on large-scale defects is still not good.
[0004] In short, due to the limitation of process conditions and raw materials, the existing tissue engineering porous scaffolds do not have good biocompatibility. There are certain limitations

Method used

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  • Tissue engineering scaffold, preparation method thereof and 3D printing ink capable of being directly biologically mineralized
  • Tissue engineering scaffold, preparation method thereof and 3D printing ink capable of being directly biologically mineralized
  • Tissue engineering scaffold, preparation method thereof and 3D printing ink capable of being directly biologically mineralized

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Embodiment Construction

[0040]In order to illustrate the technical solutions of the present invention more clearly, the claims of the present invention will be described in further detail below with reference to specific embodiments and drawings. It is regarded as limiting the scope, and the limited number of modifications made by anyone within the scope of the claims of the present invention are still within the scope of the claims of the present invention.

[0041] A directly biomineralizable 3D printing ink, including a hydrogel;

[0042] The hydrogel comprises a sodium alginate complex and a concentrated sodium alginate containing a phosphorus source;

[0043] The concentration range of the phosphorus source is 0.1mol / L~1.5mol / L;

[0044] The mass fraction of sodium alginate in the hydrogel is 10% to 20%;

[0045] The mass fraction of the sodium alginate complex in the hydrogel is 5% to 20%.

[0046] In certain embodiments of the invention, growth factors are also loaded.

[0047] As mentione...

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Abstract

The invention provides a tissue engineering scaffold, a preparation method thereof and a 3D printing ink capable of being directly biologically mineralized. The tissue engineering scaffold comprises ahigh molecular hollow tubular structure, and the surface of the scaffold is uniformly covered with a nano-hydroxyapatite layer with controllable thickness. The tissue engineering scaffold can be widely applied to filling and reconstruction of bone tissues. The preparation method of the tissue engineering scaffold is carried out by virtue of shell-core coaxial spray head 3D printing under bio-safety conditions, and a three-dimensional scaffold stacked by hollow pipes can be efficiently prepared. The scaffold comprises an open macroporous structure and a controllable hollow pipe structure. Compared with straight-through hole scaffolds prepared by virtue of an existing template method, the tissue engineering scaffold has two types of hole structures, and the tubular orientation is controllable. The uniformly-distributed and thickness-controllable nano-hydroxyapatite layer is rapidly mineralized on the surface of a high molecular hollow tubular scaffold, so that the adhesion and multiplication of cells and the osteogenic differentiation can be remarkably improved.

Description

technical field [0001] The present invention relates to the technical field of tissue engineering, in particular, to a tissue engineering scaffold, a preparation method thereof, and a 3D printing ink that can be directly biomineralized. Background technique [0002] Tissue engineering and regenerative medicine are the application of the principles and technologies of life science and engineering, based on the correct understanding of the relationship between the tissue structure and function of mammals in both normal and pathological states, research and development for the repair, maintenance, and promotion of the human body. An emerging discipline of biological substitutes for the function and morphology of various tissues or organs following injury. Three-dimensional porous tissue repair scaffold refers to a multifunctional scaffold with a large number of pore structures of a certain size and a high specific surface area. It plays a crucial role in tissue engineering and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/52A61L27/56A61L27/50A61L27/54A61L27/12A61L27/20B33Y70/00B33Y80/00B33Y10/00
CPCA61L27/12A61L27/20A61L27/50A61L27/52A61L27/54A61L27/56A61L2300/414A61L2430/02A61L2430/12B33Y10/00B33Y70/00B33Y80/00C08L5/04
Inventor 罗永祥魏销玥林欣黄鹏
Owner SHENZHEN UNIV
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