6 results about "Three dimensional scaffolds" patented technology

The present disclosure provides, among other things, a method of isolating and expanding gamma delta (γδ) T cells, wherein the method comprises: (a) isolating non-hematopoeitic tissue by biopsy or explant, and (b) culturing the isolated non-hematopoeitic tissue in the absence of a three-dimensional scaffold or grid, thereby expanding and isolating gamma delta (γδ) T cells.

The present disclosure relates generally to chemical sensors and polymer coatings for chemical sensors, and more particularly to a sensing system including a sensor having a polymeric 3D printed coating disposed on a surface thereof. A sensing system includes a sensor including a resonator structure. The sensing system includes a polymeric 3D printed coating disposed on a surface of at least a portion of the sensor. The polymeric 3D printed coating includes a three-dimensional scaffold structure.

This invention discloses a three-dimensional visualization organoid culture device, belonging to the field of organoid culture technology. It includes a control center, which is communicatively connected to a virtual three-dimensional scaffold module, a laser visualization monitoring module, a biolayer interference sensing module, and an automated culture medium control module. This invention abandons the traditional matrix gel solid scaffold and employs focused acoustic vortex technology to construct a dynamically adjustable virtual acoustic trap array. It utilizes acoustic radiation force to achieve cell capture and spatial arrangement, avoiding the interference of uncertainties in the composition and biocompatibility differences of solid scaffolds on organoid growth. Simultaneously, the acoustic trap array can adaptively reconstruct its topology according to the cell aggregation stage and metabolic state, solving the problem that traditional scaffold structures cannot adapt to dynamic cell growth, improving the morphological uniformity and physiological relevance of organoids, and providing a high-quality culture medium for organoid research and clinical applications.

Three-dimensional scaffolds to facilitate engineered tissue growth are described herein. An exemplary scaffold comprises a first capillary element, a second capillary element, and a connective element that spans a distance between the first capillary element and the second capillary element, connecting the capillary elements. Tissues can be grown within the scaffold such that the tissues have highly vascularized structures with many capillaries running throughout. The scaffolds can be fabricated by selective electrochemical etching of a semiconductor element. The electrochemical etching can be controlled by way of a laser configured to stimulate multiphoton absorption in the semiconductor.

This invention relates to a three-dimensional scaffold based on chirality and peptides for selective cell adhesion, its preparation method, and its applications, relating to the field of medical products. The three-dimensional scaffold is a stacked, three-dimensional ordered structure, with each layer comprising several ordered polyelectrolyte multilayer membrane soft carriers arranged at an angle between adjacent layers. Each layer of the polyelectrolyte multilayer membrane is formed by alternating deposition of positively charged chiral molecules grafted with specific recognition groups and negatively charged supramolecular polyelectrolytes on the soft carriers, followed by modification with peptides. The two peptides in adjacent polyelectrolyte multilayer membranes are different and are used to promote the specific adhesion of different cells. The three-dimensional scaffold provided by this invention has specific adhesion properties, thereby avoiding excessive cell proliferation in incorrect locations and helping to prevent problems such as re-injury and stenosis of artificial blood vessels.