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Clay-based hydrogel matrix for three-dimensional printing and preparation method application thereof

A three-dimensional printing and hydrogel technology, applied in medical science, prosthesis, additive processing, etc., can solve the problems of inability to print, reduce material selectivity, and high gel slurry, achieve simple process and improve three-dimensional printing. Efficiency, suitable viscosity effect

Inactive Publication Date: 2017-05-10
SHENZHEN INST OF ADVANCED TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, after adding a thermal initiator to the gel system in thermal polymerization, the polymerization time is uncontrollable, and the pressure required for printing needs to be adjusted at any time, or it may be due to too fast polymerization, which may cause the problem that printing cannot be done later.
The use of ultraviolet light to cure the three-dimensional scaffold does not have the above problems. It can cure the gel paste while printing it. UV cross-linking occurs in the gel, otherwise the structure of the printed gel scaffold cannot be well maintained, thus greatly reducing the selectivity of the material

Method used

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  • Clay-based hydrogel matrix for three-dimensional printing and preparation method application thereof
  • Clay-based hydrogel matrix for three-dimensional printing and preparation method application thereof
  • Clay-based hydrogel matrix for three-dimensional printing and preparation method application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] A method for preparing a clay-based three-dimensional gel support, comprising the steps of:

[0081] A. Preparation of double bond modified polyethylene glycol (Mn=4000) macromolecular cross-linking agent

[0082] First, 1.2 ml of acryloyl chloride was dissolved in 10 ml of dichloromethane to prepare an acryloyl chloride solution. Subsequently, 10 g of polyethylene glycol (Mn=4000) was placed in a 50 ml three-neck flask, 20 ml of dichloromethane was added to dissolve, and the mixture was stirred evenly at room temperature. Under ice-water bath conditions, 2.1 ml of triethylamine solution was slowly added. Subsequently, under the condition of an ice-water bath, the acryloyl chloride solution prepared in advance was added dropwise. The temperature of the system was controlled to zero until all the acryloyl chloride was added dropwise, and the reaction was carried out at room temperature for 24 hours under the protection of nitrogen. After the reaction, the triethylamin...

Embodiment 2

[0094] A method for preparing a clay-based three-dimensional gel support, comprising the steps of:

[0095] (1) Using the same method as in Example 1, the polyethylene glycol with a molecular weight of 4000 is modified with a double bond to obtain the crosslinking agent polyethylene glycol diacrylate, CH 2 =CHCO-(OCH 2 CH 2 ) n OCOCH=CH 2 (n is 88);

[0096] (2) Adopt 2-hydroxyl-4'-(2-hydroxyethoxyl)-2-methyl propiophenone as ultraviolet photoinitiator, LaponiteXLG as inorganic clay, weigh crosslinking agent, inorganic Clay and ultraviolet photoinitiator were added to water and mixed evenly to obtain a clay-based hydrogel matrix with a viscosity of 170Pa·s. The above-mentioned raw materials were mixed according to the following mass percentages:

[0097] Cross-linking agent: 30%;

[0098]Inorganic clay: 8%;

[0099] UV photoinitiator: 0.05%;

[0100] Water: 61.95%;

[0101] (3) Three-dimensionally print the above-mentioned clay-based hydrogel matrix at normal temperat...

Embodiment 3

[0103] A method for preparing a clay-based three-dimensional gel support, comprising the steps of:

[0104] (1) Using the same method as in Example 1, the polyethylene glycol with a molecular weight of 10000 is modified with a double bond to obtain the crosslinking agent polyethylene glycol diacrylate, CH 2 =CHCO-(OCH 2 CH 2 ) n OCOCH=CH 2 (n is 224);

[0105] (2) Adopt 2-hydroxyl-2-methyl-1-phenyl-1-propanone as ultraviolet photoinitiator, Laponite XLG as inorganic clay, weigh crosslinking agent, inorganic clay, ultraviolet light according to the following formula quantity Initiator, add water and mix evenly to obtain a clay-based hydrogel matrix with a viscosity of 150Pa·s, and the above-mentioned raw materials are mixed according to the following mass percentages:

[0106] Cross-linking agent: 20%;

[0107] Inorganic clay: 7%;

[0108] UV photoinitiator: 0.05%;

[0109] Water: 72.95%;

[0110] (3) Three-dimensionally print the above-mentioned clay-based hydrogel ma...

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Abstract

The invention provides a clay-based hydrogel matrix. The clay-based hydrogel matrix is prepared from, by mass, 10-50% of cross-linking agent, 3-20% of inorganic clay, 0.05-0.1% of ultraviolet light initiator and 30-86% of water, wherein the total mass of the ingredients is 100%, the crosslinking agent is biologically compatible macromolecules with carbon-carbon double bonds, the biologically compatible macromolecules are one or more of polyethylene glycol, polyvinyl alcohol, chitosan, gelatin and hyaluronic acid. The clay-based hydrogel matrix is simple in formula, safe in ingredients and appropriate in viscosity, has a certain pre-formed shape, is suitable for continuously extruded three-dimensional scaffold printing and can achieve that printing is prior to curing for gelling and three-dimensional scaffolds are printed in a large-scale mode, and the three-dimensional scaffold printing efficiency is greatly improved. The invention further provides a preparation method based on the clay-based hydrogel matrix and application.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to a clay-based hydrogel matrix for three-dimensional printing and its preparation method and application. Background technique [0002] Hydrogel is a polymer with a three-dimensional network structure formed by covalent bonds, hydrogen bonds or van der Waals forces, which can swell in water and retain a large amount of water without dissolving. Due to natural or synthetic Polymer hydrogels are similar to biological tissues in structure and performance. Therefore, in the past 20 years, hydrogels have been used in the field of biomedical engineering, especially in the diagnosis, treatment, repair or replacement of human tissues and organs in tissue engineering or the enhancement of other tissues. It is a research hotspot of functions and growth factors, drugs and gene carriers. [0003] Thermal polymerization and ultraviolet polymerization are more commonly used polymerization ...

Claims

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Application Information

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IPC IPC(8): C08J3/28C08J3/075C08L71/02C08L89/00C08L5/08C08K3/34A61L27/52A61L27/50A61L27/02B33Y70/00
CPCC08J3/28A61L27/02A61L27/50A61L27/52A61L2430/02B33Y70/00C08J3/075C08J2305/08C08J2371/02C08J2389/00C08K3/346C08L5/08C08L71/02C08L89/00
Inventor 阮长顺翟欣昀马宇飞潘浩波
Owner SHENZHEN INST OF ADVANCED TECH
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