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A bionic liver tissue engineering scaffold and forming process thereof

A tissue engineering scaffold, bionic liver technology, applied in tissue cell/virus culture devices, biochemical instruments, biochemical equipment and methods, etc., can solve problems such as poor controllability, difficult to build structures, and complexity, and improve porosity. Effect

Inactive Publication Date: 2006-12-27
XI AN JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these processes have poor controllability, and it is difficult to construct a scaffold microstructure with complex structure for multi-cell growth, and more importantly, it is impossible to realize the orderly distribution of various cells in the scaffold.

Method used

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  • A bionic liver tissue engineering scaffold and forming process thereof
  • A bionic liver tissue engineering scaffold and forming process thereof

Examples

Experimental program
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Effect test

Embodiment Construction

[0026] figure 1 It is the basic structure diagram of bionic bracket and interface. The scaffold and the interface simulate the hepatic lobule structure of the natural liver. The scaffold has two sets of independent microscopic piping systems that simulate the hepatic lobular structure, and are connected to the interfaces at both ends, respectively, for the microchannel structure of endothelial cells and hepatocyte growth ; There is no conduction between the two sets of pipelines, but they penetrate through the bracket material and exchange substances. The interfaces at both ends can be used for perfusing hepatocytes and connecting with blood vessels or nutrient solution delivery tubes respectively. The specific structure is detailed as follows.

[0027] Such as figure 1 As shown in (a): the shape of the bionic liver tissue engineering scaffold and the interface is cylindrical, which is composed of the main body of the bracket and the interface (including the sealing sleeve)...

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Abstract

Disclosed are a novel bionic hepatic tissue engineering scaffold and a interface, and producing method thereof, comprising designing a hepatic tissue engineering scaffold imitating natural hepatic lobule structure, and arranging two separate sets of micro duct structure and a interface thereof for hepatocytes and endothelial cells inside the scaffold. The micro duct interface of endothelial cells can be connected with blood vessels in the nature liver, or with the circulatory system of a bioreactor. The hepatocyte micro duct structure is used for accelerating hepatocyte diffusion when perfusing hepatocytes. A mono-layer flow passage and a interface are produced by press print method, and then pore space between two micro duct structures is formed by freeze drying, so that the porosity factor of the material is increased to make the material have certain semi-permeable membrane function. The three-dimensional scaffold and the interface thereof with hepatocyte micro duct structure and endothelial cell micro duct structure are produced by lamination bonding process.

Description

technical field [0001] The invention relates to a bionic liver tissue engineering scaffold and its manufacturing process, in particular to a bionic liver tissue engineering scaffold and interface that is biodegradable and simulates the structure of the natural liver, and uses single-layer embossing combined with freeze-drying to form holes and laminate Integrated forming process for assembly. Background technique [0002] Liver transplantation is the most effective way to treat various chronic liver diseases, but the shortage of donors has always restricted liver transplantation. Tissue engineering provides the possibility of culturing living livers in vitro, which is expected to restore more biochemical functions of human livers. However, liver tissue engineering has specific requirements for the scaffold structure: there should be three types of microstructures in the scaffold—smooth microchannels, holes, and semipermeable pores between them. Mic...

Claims

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Application Information

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IPC IPC(8): A61F2/00A61M1/14C12M3/00A61B17/00
Inventor 刘亚雄李涤尘贺健康卢秉恒
Owner XI AN JIAOTONG UNIV
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