Photo-thermal anti-tumor and osteogenesis-promoting composite material and preparation method thereof

A composite material and anti-tumor technology, applied in the field of bone repair materials and their preparation, can solve the problems of limited potential applications, no photothermal conversion effect, no photothermal effect, etc.

Pending Publication Date: 2021-03-19
SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, magnesium oxide and magnesium hydroxide do not have the photothermal conversion effect, so the implant materials composited with these magnesium particles do not have the photothermal effect, which limits the potential application of this type of composite material after bone tumor resection.

Method used

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  • Photo-thermal anti-tumor and osteogenesis-promoting composite material and preparation method thereof
  • Photo-thermal anti-tumor and osteogenesis-promoting composite material and preparation method thereof
  • Photo-thermal anti-tumor and osteogenesis-promoting composite material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] Example 1 Preparation of photothermal anti-tumor and bone-promoting composite materials

[0062] (1) Pour 90 mL of deionized water, 40 mL of absolute ethanol and 2.1 mL of ammonia water with a mass fraction of 25-28% into a beaker to obtain a mixed solvent. Dissolve 0.5g of dopamine hydrochloride in the above solution, stir at room temperature, then add nano magnesium oxide particles (0.2g, 0.5g, 1g, 1.5g, 2g) to the solution, and continue stirring at room temperature for more than 24 hours, Centrifuge, wash three times with deionized water, and freeze-dry to obtain polydopamine (PDA) and polydopamine composite magnesium oxide particles (PDA@MgO-Nps). Among them, 0.2PDA@MgO-Nps, 0.5PDA@MgO-Nps, 1PDA@MgO-Nps, 1.5PDA@MgO-Nps, 2PDA@MgO-Nps respectively means adding 0.2g, 0.5g, 1g, 1.5 The scheme of g, 2g nano magnesium oxide particles. The particle has a near-infrared photoresponse effect, that is, it can convert light energy into heat energy under near-infrared light. ...

Embodiment 2

[0069] Example 2 Preparation of photothermal anti-tumor and bone-promoting composite materials

[0070] (1) 90mL deionization is mixed with 40mL dehydrated ethanol, add 2.1mL mass fraction and be the ammoniacal liquor of 15wt%, make mixed solvent after stirring at room temperature, 0.5g dopamine hydrochloride is dissolved in this mixed solvent, Subsequently, 1.5 g of magnesium oxide was added, stirred at room temperature for 24 hours, centrifuged, washed with deionized water for more than three times, and then freeze-dried to obtain polydopamine composite magnesium oxide particles.

[0071](2) Weigh 9g of hyaluronic acid with a molecular weight greater than 20kDa and add it to 300mL of deionized aqueous solution. After it is completely dissolved, add 5mL of methacrylic anhydride (MA) dropwise to the hyaluronic acid aqueous solution at a rate of 0.5mL / min , and add a small amount of sodium hydroxide to the solution, adjust the pH of the solution to weak alkaline, stir overnight...

Embodiment 3

[0073] Example 3 Preparation of photothermal anti-tumor and bone-promoting composite materials

[0074] (1) 90mL deionization is mixed with 40mL dehydrated ethanol, add 2.1mL mass fraction and be the ammoniacal liquor of 15wt%, make mixed solvent after stirring at room temperature, 0.5g dopamine hydrochloride is dissolved in this mixed solvent, Subsequently, 1.5 g of magnesium oxide was added, stirred at room temperature for 24 hours, centrifuged, washed with deionized water for more than three times, and then freeze-dried to obtain polydopamine composite magnesium oxide particles.

[0075] (2) Weigh 9g of sodium alginate with a molecular weight greater than 20kDa and add it to 300mL of deionized aqueous solution. After it is completely dissolved, add 5mL of methacrylic anhydride (MA) dropwise to the sodium alginate aqueous solution at a rate of 0.5mL / min. , and add a small amount of sodium hydroxide to the solution, adjust the pH of the solution to weak alkaline, stir overnig...

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Abstract

The invention relates to a photo-thermal anti-tumor and osteogenesis-promoting composite material and a preparation method thereof, and particularly discloses photo-thermal anti-tumor bone repair particles. The photo-thermal anti-tumor bone repair particles comprise magnesium micro-nano particles and a poly-polyphenol layer coating the magnesium micro-nano particles. The invention further discloses a photo-thermal anti-tumor bone repair particle-containing composite material. Through the method described by the invention, the magnesium-containing particles with osteogenic activity can be endowed with photo-thermal conversion properties, and the surfaces of the particles contain active functional groups capable of being crosslinked with hydrogel, so that the release of magnesium ions in themagnesium-containing hydrogel composite material is regulated and controlled. According to the method, anti-tumor and osteogenesis promoting components can be prevented from being introduced into a biological material used after bone tumor excision at the same time, and the purposes of photo-thermal anti-tumor and osteogenesis promoting can be achieved by only introducing the poly-polyphenol to modify the magnesium-containing particles.

Description

technical field [0001] The invention belongs to the technical field of bone repair materials, and relates to a bone repair material and a preparation method thereof. Background technique [0002] Bone tumor is a common orthopedic disease, which is usually removed by surgery. After bone tumor resection, it is easy to cause a large bone defect and some residual tumor cells. Large bone defects are difficult to self-heal, resulting in a high rate of disability and teratogenicity; residual tumor cells are likely to cause tumor recurrence. Therefore, there is an urgent need for an anti-tumor and osteogenic material to fill large bone defects and residual tumor cells after bone tumor resection, which can kill remaining tumor cells and promote bone defect repair. [0003] How to effectively repair the bone defect caused by bone tumor resection and kill the residual tumor cells is a thorny problem in clinical practice after bone tumor resection. In recent years, a large number of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/04A61L27/34A61L27/54A61L27/44A61L27/52
CPCA61L27/047A61L27/34A61L27/54A61L27/446A61L27/52A61L2430/02A61L2300/416A61L2300/624A61L2300/102A61L2300/412C08L79/04
Inventor 赖毓霄李彩荣陈英奇秦岭
Owner SHENZHEN INST OF ADVANCED TECH CHINESE ACAD OF SCI
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