Antibacterial and antitumor orthopaedic implantation material and preparation method thereof

An implant material and anti-tumor technology, applied in medical science, prosthesis, etc., can solve the problems of local recurrence, long duration, and long time consumption, so as to prevent recurrence and metastasis, prevent adhesion and reproduction, and avoid the use of antibiotics Effect
CN103463675AInactive Publication Date: 2013-12-25GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
GUANGZHOU GENERAL HOSPITAL OF GUANGZHOU MILITARY COMMAND
Publication Date
2013-12-25
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an antibacterial and antitumor orthopaedic implantation material and a preparation method thereof. The implantation material is a medical pure titanium sheet with the surface modified by chitosan, methotrexate, heparin sodium, polylysine and dopamine. According to the material, dopamine serves as a bridge to allow polylysine and a heparin sodium particle to be bonded on the surface of titanium; heparin, as a good anticoagulant, can improve biocompatibility between the material and blood, and is bonded with chitosan and methotrexate with antibacterial and antitumor effects through an electrostatic effect. Physiological-biochemical characteristics of drugs are utilized ingeniously to form an orderly and uniform antibacterial and antitumor coating with high biocompatibility on the surface of the titanium, and the prepared implantation material has good antibacterial and antitumor activity, and can effectively prevent bacterial adhesion and reproduction, as well as recurrence and transfer of a cancer.
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Description

technical field

[0001] The invention belongs to the field of biomedical materials, and relates to an orthopedic implant material and a preparation method thereof, in particular to an antibacterial and anti-tumor orthopedic implant material and a preparation method thereof. Background technique

[0002] The traditional treatment of bone and soft tissue tumors is extensive resection of tumors including normal tissues, tumor inactivation and reimplantation, and various artificial prosthesis replacements such as endoluminal catheterization, joint replacement, and various biological bone implants. Limb salvage treatment by transplantation and other methods, and in the process of bone tumor surgery, due to the particularity of the tumor site, such as joints and spine, a large number of blood vessels and nerves are often adhered, which will take a long time during the entire operation and easily lead to infection . At present, in order to avoid the infection caused by the initial ...

Claims

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