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Spherical mesoporous calcium silicate/chitosan three-dimensional porous scaffold material, preparation method and application

A scaffold material, three-dimensional porous technology, applied in medical science, prosthesis, etc., can solve problems such as low bone fitness, insufficient bone fitness, irregular structure, etc., and achieve good biological functionality and good biocompatibility Sexuality, the effect of promoting bone regeneration

Active Publication Date: 2020-10-16
SHANGHAI NORMAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Chinese patent CN201410804632.3 discloses a preparation method of mesoporous calcium magnesium silicate. The material prepared by this method has good mechanical compatibility and antibacterial properties, and can stimulate bone growth, but the mesoporous silicic acid prepared by this method The microstructure of calcium and magnesium is irregular, and the agglomeration phenomenon is obvious
[0007] Chinese patent CN200810121129.2 discloses a method for preparing a three-dimensional ordered porous chitosan bone repair scaffold material. The performance is not obvious, and the mechanical strength is low, and the bone compatibility is low
[0008] Chinese patent CN201710337181.0 discloses a preparation method of a natural bone repair material that promotes bone regeneration. A scaffold is obtained by mixing α-tricalcium phosphate, β-tricalcium phosphate, carboxymethyl cellulose composite powder and deionized water into a press molding. It has good biocompatibility and osteoinductive activity, but the scaffold material does not have a three-dimensional porous structure, cannot provide a transport channel for cell metabolic waste and nutrients, and the degradation rate of β-tricalcium phosphate is too fast to be effective for a long time repair bone defects
[0009] At present, the scaffold materials prepared from a single mesoporous material or a single chitosan have problems such as irregular structure, low mechanical strength, and insufficient bone fitness. Composite scaffold materials prepared from a variety of biomaterials for bone repair Due to the lack of porous structure and excessive degradation speed, it is impossible to form an ideal scaffold material for bone repair

Method used

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  • Spherical mesoporous calcium silicate/chitosan three-dimensional porous scaffold material, preparation method and application
  • Spherical mesoporous calcium silicate/chitosan three-dimensional porous scaffold material, preparation method and application
  • Spherical mesoporous calcium silicate/chitosan three-dimensional porous scaffold material, preparation method and application

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Experimental program
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Effect test

Embodiment 1

[0050] (1) Dissolve 1 g of cetyltrimethylammonium bromide (CTAB) in 350 mL of deionized water in a water bath at 25° C. to form a CTAB solution.

[0051] (2) Add 1.5mL of ammonia water with a concentration of 0.1mol / L to the CTAB solution, stir for 0.5h until the solution is completely dissolved, adjust the pH to about 10, then add 5mL tetraethyl orthosilicate (TEOS) and 5.2g nitric acid tetrahydrate in sequence Calcium, the molar weight of TEOS is about 22.47mmol, the molar weight of calcium nitrate tetrahydrate is about 22.03mmol, the molar ratio of silicon element and calcium element is about 1:1, the molar ratio of TEOS and CTAB is about 8:1, stir 2h, let stand for 12h, filter with suction, and wash 5 times with deionized water to obtain a white precipitate.

[0052] (3) The white precipitate obtained in step (2) was dried in an oven at 60°C, and then calcined at 500°C (2°C / min) in a muffle furnace for 4 hours to obtain spherical mesoporous calcium silicate. The average s...

Embodiment 2

[0060] (1) Dissolve 1 g of cetyltrimethylammonium bromide (CTAB) in 600 mL of deionized water in an oil bath at 80° C. to form a CTAB solution.

[0061] (2) Add 3 mL of ammonia water with a concentration of 12 mol / L to the CTAB solution, stir for 2 hours until it dissolves completely, adjust the pH to about 12, then add 8 mL of TEOS and 6.048 g of calcium hydrogen phosphate in sequence, the molar weight of TEOS is about 35.95 mmol, The molar weight of calcium nitrate tetrahydrate is about 35.16mmol, the molar ratio of silicon element and calcium element is about 1:1, and the molar ratio of TEOS and CTAB is about 13:1, stir for 5h, let stand for 48h, suction filter, use After washing with deionized water 5 times, a white precipitate was obtained.

[0062] (3) After the white precipitate obtained in step (2) was dried in an oven at 100°C, it was calcined at 700°C (2°C / min) in a muffle furnace for 8 hours to obtain spherical mesoporous calcium silicate. The average surface pore ...

Embodiment 3

[0070] (1) Dissolve 1 g of CTAB in 450 mL of deionized water in a 40°C water bath to form a CTAB solution.

[0071] (2) Add 2.4 mL of sodium hydroxide with a concentration of 6 mol / L to the CTAB solution, stir for 1 h until it is completely dissolved, adjust the pH to about 12.5, then add 7 mL of TEOS and 3.9 g of calcium chloride in sequence, the molar weight of TEOS is about 31.45mmol, the molar weight of calcium nitrate tetrahydrate is about 35.14mmol, the molar ratio of silicon and calcium is about 0.9:1, the molar ratio of TEOS and CTAB is about 11.4:1, stirring for 3h, standing for 24h, suction filtration , and washed 10 times with deionized water to obtain a white precipitate.

[0072] (3) After the white precipitate obtained in step (2) was dried in an oven at 80°C, it was calcined at 600°C (2°C / min) in a muffle furnace for 6 hours to obtain spherical mesoporous calcium silicate. The average surface pore diameter of spherical mesoporous calcium silicate is 30nm, and t...

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Abstract

The invention relates to a three-dimensional porous support material of spherical mesoporous calcium silicate / chitosan, a preparation method and application. The support material contains chitosan andspherical mesoporous calcium silicate, spherical mesoporous calcium silicate is attached to the pore walls of large pores formed by chitosan, the surface of spherical mesoporous calcium silicate is coated with chitosan thin film, three-dimensional through pore structures are formed, the diameters of the large pores are 5-500 micrometers, and the porosity is 20-90%; the average superficial pore diameter of spherical mesoporous calcium silicate is 2-50 nm, and the specific surface area is 150-350 m<2> / g. The three-dimensional porous support material of spherical mesoporous calcium silicate / chitosan has good biomaterial properties and bone inductivity, can be directly placed in a focus part, is beneficial to promotion of targeting and slow releasing effects of bone medicines, and has good application prospects in the field of bone repair materials; moreover, the preparation method of the support material is simple, operation is convenient, and the support material is friendly to the environment.

Description

technical field [0001] The invention relates to the preparation technology of artificial bone repair materials in the fields of biological materials and inorganic non-metallic materials, specifically spherical mesoporous calcium silicate / chitosan three-dimensional porous scaffold materials, preparation methods and applications. Background technique [0002] Bone tissue diseases and defects are quite harmful to people's daily life. The local bone defects caused by bone trauma and osteosarcoma surgery cannot be repaired by the body's own ability. Therefore, it is necessary to use implant materials to assist the repair and healing of damaged tissues. Bone tissue repair requires biomaterials to have excellent biocompatibility, osteoconductivity, and osteoinductivity, and to better adapt to natural bone tissue. A wide variety of biomaterials are currently used for bone repair, mainly including hydroxyapatite, tricalcium phosphate, bioglass, calcium phosphate bone cement, and mes...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/20A61L27/02A61L27/58A61L27/56A61L27/54
Inventor 郭亚平温玺胡敏尹瑞柯勤飞徐合
Owner SHANGHAI NORMAL UNIVERSITY
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