Method for constructing ionic gel drug-loaded coating on surface of biodegradable metal

A technology of ion gel and metal surface, which is applied in the fields of coating, medical science, surgery, etc., can solve the problem that it is difficult to take into account the corrosion of zinc-based metals to control the biological functions of zinc-based metals, the effect is not very ideal, and the surface modification method is single, etc. problems, achieve the effects of reducing the release of zinc ions, promoting the adhesion of osteoblasts, and improving the anti-inflammatory properties

Active Publication Date: 2022-03-01
SOUTHWEST JIAOTONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, most of the current surface modification methods for biodegradable zinc metal are relatively simple, and it is difficult to control the corrosion of zinc-based metals and improve the biological functions of zinc-based metals. The effects of these modification methods are not very ideal.

Method used

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  • Method for constructing ionic gel drug-loaded coating on surface of biodegradable metal
  • Method for constructing ionic gel drug-loaded coating on surface of biodegradable metal
  • Method for constructing ionic gel drug-loaded coating on surface of biodegradable metal

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] This example provides a method for constructing an ion gel drug-loaded coating on a biodegradable metal surface, including the following steps:

[0043] a. Pretreatment of zinc flakes: Grind the zinc flakes gradually with 600#, 1200#, 2000# sandpaper, then clean them sequentially with deionized water and absolute ethanol under ultrasonic conditions, and finally dry them for later use;

[0044] b. Phosphorylation treatment of zinc flakes: place the polished zinc metal flakes in the above steps in 7.68g / L NaH 2 PO 4 ,1.85g / L Zn(NO 3 )·6H 2 O mixed solution, soaked at 50°C for two hours, then cleaned with deionized book, dried for later use;

[0045] c. Configuration of gel solution and ionic solution: Mix 10g / L carboxymethyl chitosan solution and 10g / L gelatin solution at 50°C to form carboxymethyl chitosan / gelatin mixed solution ; The Zn(NO of 5.94g / L 3 )·6H 2 O and 0.05g / L aspirin are mixed under the condition of 50°C to configure a zinc ion / carrier drug mixed sol...

experiment example 1

[0051] In this example, the sample of the ion gel drug-loaded coating prepared in Example 1 was tested by infrared spectroscopy by reflection method.

[0052] Infrared spectroscopy test results such as figure 2 shown. at 1260cm -1 At , the characteristic peak of N-H appeared in the coating, which was derived from gelatin, indicating that gelatin was successfully built in the coating. at 1346cm -1 At , the characteristic peak of C-H appeared in the coating, which was derived from carboxymethyl chitosan, indicating that carboxymethyl chitosan was successfully built in the coating. at 1747cm -1 , the characteristic peak of -O-CO appeared in both the coating and the aspirin powder, indicating that the aspirin drug was loaded in the coating.

experiment example 2

[0054] In this example, a conductive silver glue is coated on the surface of the polished zinc sheet and the coated zinc sheet prepared in Example 1 to connect it with the wire, and then seal the other parts of the sample except the coated surface with silicon rubber. Finally, put the processed sample into the three-way tube with Hank's solution as the electrolyte, in which the sample is used as the working electrode, the metal platinum is used as the counter electrode, and the calomel electrode is used as the reference electrode. Using IM6 electrochemical The workstation is used to test the potentiodynamic polarization curve of the sample.

[0055] The polarization curve of the sample in this example is as follows image 3 shown. As shown in the figure, the self-corrosion potential E of the sample after coating modification corr Correction, self-corrosion current i corr decreased, indicating that the coating can slow down the corrosion of the zinc substrate.

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Abstract

The invention discloses a method for constructing an ionic gel drug-loaded coating on the surface of biodegradable metal, and belongs to the technical field of surface modification of biodegradable metal materials, the method comprises the following steps: step (1): carrying out phosphorylation treatment on the surface of a pretreated zinc substrate; and (2) alternately depositing the zinc substrate obtained in the step (1) in the carboxymethyl chitosan / gelatin mixed solution and the zinc ion / carrier drug mixed solution. According to the invention, a gelatin / carboxymethyl chitosan coating is formed on the surface of zinc metal by utilizing covalent binding between gelatin and carboxymethyl chitosan; zinc ions are added as a chelating agent / ionic cross-linking agent, and aspirin and other drugs are added as carrier drugs; and after alternate deposition, a layer of ionic gel coating loaded with a medicine is constructed on the surface of the zinc metal. According to the surface modification method for the biodegradable zinc metal, the aims of controlling corrosion and degradation of the zinc-based metal and improving the biological functionality are both achieved.

Description

technical field [0001] The invention relates to the technical field of surface modification of biodegradable metal materials, in particular to a method for constructing an ion gel drug-loaded coating on the surface of biodegradable metals. Background technique [0002] At present, zinc and its alloys have been considered as the most potential biodegradable metal materials because of their more moderate degradation rate and good biosafety compared with magnesium-based and iron-based metals. Compared with iron-based and magnesium-based metal materials, zinc-based metal materials have better biocompatibility and better corrosion behavior in physiological environments. However, the metal material of degradable zinc-based implants has an uneven corrosion pattern in the body. During the degradation process, a large amount of zinc ions are locally released, causing severe cytotoxicity, causing damage to surrounding cells and tissues, and leading to premature implant corrosion. inv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/02A61L31/16A61L31/10A61L31/08
CPCA61L31/022A61L31/16A61L31/10A61L31/08A61L31/028A61L2300/606A61L2300/41A61L2300/216A61L2420/02A61L2420/06A61L2420/08C08L5/08C08L89/00
Inventor 万国江王佳乐钱军余张文泰王鹏毛金龙黄楠
Owner SOUTHWEST JIAOTONG UNIV
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