159results about How to "Good anticoagulant effect" patented technology

A catheter lock composition for preventing bacterial infection having an effective amount of glycerol and sodium chloride solution. The effective amount of glycerol is between about 35-60% and sodium chloride is in a concentration range between 0.5-0.9%. The composition further includes an anticoagulant and/or an antimicrobial agent.

The invention discloses a Chinese medicine combination for treating cardio-cerebral vascular diseases, which is composed of raw materials with the following parts by weight: 30-50 parts of radix astragali, 20-25 parts of angelica, 15-20 parts of hemlock parsley, 30-50 parts of salvia miltiorrhiza, 15-20 parts of pseudo-ginseng, 15-20 parts of hawkthorn and 20-30 parts of radix puerariae; the Chinese medicine combination of the invention has ingenious compatibility, simple prescription, broad source of raw materials, low price as well as the efficacies of tonifying both qi and blood, balancing yin and yang, activating blood circulation and dissolving stasis; the Chinese medicine combination can soften blood vessels through reducing blood fat and blood viscosity and eliminating blood scales and finally achieve the purposes of smoothing blood circulation and activating cardio-cerebral function; furthermore, the Chinese medicine combination has unique efficacy for resisting atherosclerosis as well as significant curative effect on cardio-cerebral vascular diseases like coronary heart disease, cerebral thrombosis, and the like; the total clinical effective rate can reach over 95% and the Chinese medicine combination can achieve good preventive and health care effect through long-term oral administration and has safe oral administration and no toxicity and side effect.

The invention provides an anticoagulant fiber membrane and a preparation method and application thereof. The anticoagulant fiber membrane comprises a polyvinylidene fluoride membrane and a metal organic framework material with a carboxyl group, and the metal organic framework material with the carboxyl group is uniformly dispersed in the polyvinylidene fluoride membrane. The metal organic framework material in the anticoagulant fiber membrane can stably exist in a polyvinylidene fluoride membrane matrix. In addition, the anticoagulant fiber membrane has a good anticoagulant effect, and the result of the embodiment shows that the prothrombin time of the activated part of the anticoagulant fiber membrane is 42-60 seconds, and the anticoagulant effect is better. The anticoagulant fiber membrane has better hydrophilic properties, and the result of the embodiment shows that the contact angle between the anticoagulant fiber membrane and water is 50-80 degrees.

The invention discloses an anticoagulation modification method for a hemodialyzer and an application thereof. The anticoagulation modification method for the hemodialyzer comprises the following steps: triggering polymerization cross-linking reaction of a uniform mixed reaction system of olefine acid monomer, sodium sulfonate monomer, cross-linking agent monomer, initiator and water under a protective atmosphere, thereby acquiring an active heparinoid aqueous solution; keeping the membrane silk inner surface of hemodialyzer in touch with the active heparinoid aqueous solution, and then separating; heating the hemodialyzer under an acidic condition and performing auto-agglutination cross-linking, thereby acquiring the hemodialyzer with high anticoagulation property. The hemodialyzer prepared according to the invention has excellent blood compatibility and high anticoagulation property; the anticoagulation modification technology is based on a water-base system in the whole process; during the whole modifying process, only the required heparinoid substances and water are introduced; the posttreatment, such as subsequent cleaning of membrane silk, is simple; the processing steps are simple, easy for operation and realization and easy for industrial production and popularization.

There are provided a polyol curable fluororubber composition using a fluororubber of general use, a cured fluororubber formed article used as a grommet, a seal packing and the like for a gas sensor which can be used under high temperature circumstances using this, and a method of producing the same. A polyol curable fluororubber composition, which comprises 100 parts by weight of a fluororubber, 6 to 15 parts by weight of magnesium oxide, 0.5 to 5 parts by weight of a hydrotalcite group compound and 20 to 55 parts by weight of a mixture of thermal black and a bituminous coal filler. A cured fluororubber formed article which is produced by forming and curing the fluororubber composition in the presence of a polyol curing agent, and then subjecting the cured formed product to a stepwise temperature elevation treatment in a temperature range of 100° C. to 300° C. According to the present invention, an article which can be used as a grommet, seal packing and the like for a gas sensor under high temperature circumstances, such as an oxygen sensor for an automobile, can be produced, at a reduced cost.

The invention belongs to the technical field of membranes, and in particular relates to a modified polyvinylidene fluoride (PVDF) hollow fiber membrane for hematodialysisa, and a preparation method thereof. A PVDF body is modified by using acryloyl morpholine with rejecting performance on protein adsorption and cell adhesion and acrylic acid with high hydrophilic performance to prepare a hollow fiber membrane; the surface of the membrane is subjected to surface modification by L-arginine with an anticoagulation effect; and the anti-pollution performance, the blood compatibility and the anticoagulation performance of the membrane are finally improved, and a modified hollow fiber hemodialysis membrane with high biocompatibility and anticoagulation performance is obtained. The process provided by the invention is simple and can be applied to the field of hemodialysis.

The invention provides a venous retention needle suite with a hirudin anticoagulation tube sealing device, which comprises a casing, a transparent tee joint and a transfusion joint, wherein the casing is guided by a puncture needle and inserted into a vein; the transparent tee joint is connected to a built-in isolated sealing plug at the rear end of the casing; the transfusion joint is connected with a transfusion tube or a blood taking tube; the transparent tee joint is connected with the transfusion joint by an extension tube; the transfusion joint is sealed by a sealed end cap; one end of the transparent tee joint connected with the extension tube forms a double-cavity joint; one end of the double-cavity joint is connected with the extension tube, and the other end of the double-cavity joint is connected with a tube sealing device; and the tube sealing device comprises a liquid storing bag in a support and a roller which is arranged between the two side walls of the support and used for pushing the liquid in the liquid storing bag forwards. The venous retention needle suite with the hirudin anticoagulation tube sealing device can ensure that a tubular cavity of the retention needle is filled with the tube sealing liquid. The tube sealing liquid in the tube sealing device is hirudin diluent which has good anticoagulation effect and does not influence any index of serum test in blood.

A method of producing cross-linked rubber including a step of reacting a polyether rubber composition at 130 to 200° C., the polyether rubber composition containing 100 parts by weight of epihalohydrin monomer units, 0.1 to 100 parts by weight of a five-membered ring or six-membered ring nitrogen atom-containing aromatic heterocyclic type compound, and 0.1 to 10 parts by weight of at least one cross-linking agent which is selected from sulfur, a sulfur-containing compound, and triazine-based compound.

The invention discloses an anticoagulation PVDF flat separation film, also discloses a making method of the anticoagulation PVDF flat separation film, and belongs to the technical field of films. The making method of the anticoagulation PVDF flat separation film comprises the following steps: 1, preparing a polyacrylic acid grafted polyvinylidene fluoride copolymer PVDF-g-PAA; 2, making a PVDF-g-PAA flat separation film; and 3, making an argatroban grafted and modified PVDF-ARG film. A PVDF film is modified by micro-molecular argatroban with a high efficiency anticoagulation effect with acrylic acid as a medium in order to obtain a PVDF separation film material with a good anticoagulation effect. The anticoagulation PVDF flat separation film can obviously prolong the recalcification time of the film, substantially reduces adhesion of platelet erythrocytes on the surface of the film, reduces the hemolysis rate, improves the anticoagulation performance and greatly improves the blood compatibility. The method has the characteristics of simple process and easy industrialization enforcement.

The invention relates to special flavor pork skin paste and a production method thereof and belongs to food processing technologies. Fresh pork skin or thawy quickly-frozen pork skin is subjected to cleaning, rinsing, impurity removal, peculiar smell removal and particle adjustment and then is subjected to softening and anticoagulation treatment. An appropriate amount of vegetable oil, soybean paste or flour paste and aromatic seasoning are added into softened and anti-coagulated pork skin, and paste type seasoning having special flavor and smooth and mellow taste is produced through flavor enhancing and cooking treatment. The production method changes the situation that existing pork skin only can be used in solid foods and chemical materials, improves the ductility and the spreadability of pork skin foods, enables products to be easily absorbed, enables the nutritive value to be improved and enables the seasoning to be delicious and tasty.

The invention discloses a scopoletin derivative as well as a preparation method and an application thereof. The general formula of the scopoletin derivative is formula (I), wherein R is selected from C1-4 alkyl and X is selected from a halo substituent. The scopoletin derivative has a remarkable anticoagulation effect and can remarkably prolong the in vitro blood coagulation time. The scopoletin derivative orally taken can quickly enter into blood to have the anticoagulation effect. The onset time and the curative effect of the scopoletin derivative for treating venous thromboembolic diseases are equivalent to those of warfarin and the scopoletin derivative is smaller in dosage and easy to control. The scopoletin derivative has novel medical use of preventing and treating venous thromboembolic diseases and meanwhile provides a novel treatment candidate medicine for patients with venous thromboembolic diseases. The invention further discloses the preparation method of the scopoletin derivative and the application of the scopoletin derivative in preparing anticoagulation medicines.

The invention discloses a compound represented by a formula I or pharmaceutically acceptable salt thereof, a composition comprising the compound or the pharmaceutically acceptable salt thereof, and application of the compound or the pharmaceutically acceptable salt thereof and the composition in anti-coagulation medicaments.

The invention discloses modified polycarbonate with high anticoagulant activity. Modified polycarbonate is a linear macromolecular polymer, wherein a side chain of the polymer contains functionalizeddouble bonds and hydrophilic phosphorylcholine groups. Modified polycarbonate comprises copolymers A, B and C. The preparation process of modified polycarbonate comprises the following steps: copolymerizing TMC (trimethylene carbonate) and a trimethylene derivative firstly, and then grafting the side chain of the copolymer with MPC (2-methacryloyloxyethyl phosphorylcholine) through a chick reaction of dithiol and the double bonds to obtain the target product modified polycarbonate with high anticoagulant activity. According to modified polycarbonate with high anticoagulant activity, performance of polycarbonate can be changed by adjusting monomer types and proportion and quantity of the phosphorylcholine groups on the side chain, and the anticoagulant capability of polycarbonate as a biodegradable medical polymer material can be improved; reaction sites can be provided by the double bonds on the side chain for follow-up grafting with biomacromolecules or other functional molecules, theresearch potential is high, and the derivative performance is wide.

A novel animal blood anticoagulant consisting of long-chain inorganic phosphates and organic phosphates. Wherein: the weight proportion of the long-chain inorganic phosphate and the organic phosphate is: the long-chain inorganic phosphate is 25-75 parts, and the organic phosphate is 25-75 parts. The method of using the above-mentioned novel animal blood anticoagulant is: dissolve the anticoagulant and water in a ratio of 1:10 (w/w) during use, and evenly sprinkle the anticoagulant solution in the blood tank before slaughtering, and then slaughter After the start, the anticoagulant solution is evenly sprayed on the surface of the original blood during the slaughtering process of the livestock and poultry, and the addition ratio of the anticoagulant solution to the original blood is 1:15-1:20 (v/v). Compared with traditional anticoagulants, the anticoagulant has stronger anticoagulant effect, can effectively inhibit hemolysis, reduces the amount of anticoagulant used, and significantly improves the anticoagulant effect of animal blood, which is beneficial to related Enterprise mass production.

The invention relates to a tissue engineering nanofiber intravascular stent and a preparation method thereof. The stent consists of PLCL and a degradable polymer material, and has a nanofiber structure microcosmically, and the aperture is 5-10 microns. Preparation: dissolving the PLCL and a positively charged polymer in two different solvents to obtain homogeneous solutions, after dissolving completely, mixing two solution systems evenly, and performing electrostatic spinning by using a roller as a receiving device to obtain a nanofiber stent; and performing self-assembly modification by using a negatively charged degradable polymer as a surface modifier, washing by using deionized water, and drying to obtain a porous fiber stent. According to the tissue engineering nanofiber intravascular stent, the material is improved to improve the anticoagulant performance of the intravascular stent through performing self-assembly modification on a surface of the stent.

The invention discloses a hirudin anticoagulation tube sealing device for a venous retention needle, which comprises a sleeve, a transparent tee joint connected with the rear end of the sleeve, and a transfusion connector connected with a transfusion tube or a blood collecting tube; a connecting part connected with a tube sealing injector is arranged on the middle section of an extension tube; the tube sealing injector comprises a liquid tube in which a tube cavity is formed, a needle part connected with the front end of a sealed tube, and a shell which is sleeved outside the liquid tube and of which the rear end is sealed; a raised clamping wire is formed on the outer surrounding wall of the rear end of the liquid tube; a clamping groove is formed on the inner surrounding wall of the front end of the shell, and clamping steps at equal distance intervals are formed on the inner surrounding wall of the shell; and a sealing plug connected with the rear wall of the shell is arranged in the liquid tube. The hirudin anticoagulation tube sealing device for the venous retention needle can ensure the same amount of tube sealing liquid can be pushed in at each time and the tube sealing liquid can fully fill the tube cavity of the retention needle. The tube sealing liquid in the tube sealing injector is dilute solution of hirudin which has high anticoagulation effect and does not influence the test of the indexes of the serum in blood.