159results about How to "Good anticoagulant effect" patented technology

A catheter lock composition for preventing bacterial infection having an effective amount of glycerol and sodium chloride solution. The effective amount of glycerol is between about 35-60% and sodium chloride is in a concentration range between 0.5-0.9%. The composition further includes an anticoagulant and / or an antimicrobial agent.

The invention discloses an anticoagulation high polymer biomaterial which comprises a substrate layer, an anticoagulation coating, and a plasma polymerization layer positioned between the substrate layer and the anticoagulation coating, wherein the substrate layer is made of a biomedical material; the plasma polymerization layer is an allylamine plasma polymerization membrane layer deposited on the substrate layer; the anticoagulation coating is an anticoagulant layer fixed on the plasma polymerization layer; and the anticoagulants comprise hirudin, heparin and the like. Anticoagulant molecules are fixedly grafted on the material surface by utilizing the pulsed plasma technology and surface heparin grafting method, and effective molecule orientation is remained by heparin molecules, so the anticoagulant performance is close to the performance of heparin molecules in the solution. Meanwhile, the heparin molecules are difficultly scoured off by blood, the persistence and stability of the anticoagulation effect are guaranteed, and the service life is long. The invention further discloses a preparation method and application of the anticoagulation high polymer biomaterial.

The invention discloses an antibacterial and antitumor orthopaedic implantation material and a preparation method thereof. The implantation material is a medical pure titanium sheet with the surface modified by chitosan, methotrexate, heparin sodium, polylysine and dopamine. According to the material, dopamine serves as a bridge to allow polylysine and a heparin sodium particle to be bonded on the surface of titanium; heparin, as a good anticoagulant, can improve biocompatibility between the material and blood, and is bonded with chitosan and methotrexate with antibacterial and antitumor effects through an electrostatic effect. Physiological-biochemical characteristics of drugs are utilized ingeniously to form an orderly and uniform antibacterial and antitumor coating with high biocompatibility on the surface of the titanium, and the prepared implantation material has good antibacterial and antitumor activity, and can effectively prevent bacterial adhesion and reproduction, as well as recurrence and transfer of a cancer.

The invention relates to a method for manufacturing an artificial vessel bracket, in particular a compound artificial small vessel bracket. The compound artificial small vessel bracket is characterized in that the small vessel bracket comprises three layers; a net tube-shaped fabric formed by using sutures to weave medical grade poly-p-dioxanone which is strong and elastic is taken as an intermediate elastic layer; a blending sulfuric acid chondroitin-collagen coating is used as an inner layer; an outer layer is wrapped in a matrix fiber layer, then is reinforced with the sutures, and subjected to compound molding; and a degradable small-caliber (4-5 mm) vessel bracket which is similar to a normal vessel in physicochemical and biomechanical property, and matched with the regeneration of self vessel tissue. The planting of seed cells on the inner surface of the vessel bracket to form an in vitro vessel provides theoretical principles and experimental basis for the clinical application of small-caliber tissue engineering vessels in coronary artery surgery and other fields.

The invention discloses a Chinese medicine combination for treating cardio-cerebral vascular diseases, which is composed of raw materials with the following parts by weight: 30-50 parts of radix astragali, 20-25 parts of angelica, 15-20 parts of hemlock parsley, 30-50 parts of salvia miltiorrhiza, 15-20 parts of pseudo-ginseng, 15-20 parts of hawkthorn and 20-30 parts of radix puerariae; the Chinese medicine combination of the invention has ingenious compatibility, simple prescription, broad source of raw materials, low price as well as the efficacies of tonifying both qi and blood, balancing yin and yang, activating blood circulation and dissolving stasis; the Chinese medicine combination can soften blood vessels through reducing blood fat and blood viscosity and eliminating blood scales and finally achieve the purposes of smoothing blood circulation and activating cardio-cerebral function; furthermore, the Chinese medicine combination has unique efficacy for resisting atherosclerosis as well as significant curative effect on cardio-cerebral vascular diseases like coronary heart disease, cerebral thrombosis, and the like; the total clinical effective rate can reach over 95% and the Chinese medicine combination can achieve good preventive and health care effect through long-term oral administration and has safe oral administration and no toxicity and side effect.

The invention relates to a trepang compound nutritious food, which is an edible paste or soup type food which is prepared by trepang polysaccharide extracted from fresh cucumber through enzymolysis method, black fungus, jujube, wolfberry fruit, haw, chrysanthemum, wild jujube, black plum, water extract of Chinese caterpillar fungus and sesame seed. Black fungus polysaccharide can be extracted from black fungus through immersed method, and jujube polysaccharide can be extracted from jujube through enzymolysis method, wherein trepang extract which is prepared by trepang polysaccharide, black fungus polysaccharide, jujube, wolfberry fruit, haw, chrysanthemum and water extract of Chinese caterpillar fungus is suitable for aged people, trepang extract which is prepared by trepang polysaccharide, black fungus polysaccharide, jujube polysaccharide, wolfberry fruit, haw, chrysanthemum and wild jujube water extract is suitable for women, and the trepang soup which is prepared by trepang polysaccharide, black fungus polysaccharide, jujube, haw, wild jujube, water extract of black plum, sesame seed, agar and honey is suitable for children. The invention not only improves the nutritious valueof products functionally, but also increases medical value of products in medicine respect.

The present invention relates to a substrate including a compound having blood anticoagulation activity and a hydrophilic polymer compound, wherein the amount of elution of the compound having blood anticoagulation activity is less than 0.6 μg / ml, and a manufacturing method of a substrate, wherein after a compound having blood anticoagulation activity and a hydrophilic compound brought in contact with a substrate are irradiated with radiation, unreacted components are washed out.

The invention discloses an anticoagulation fibroin material, which comprises components such as fibroin protein and hirudin. An anticoagulation fibroin material preparation method comprises the following steps: (1) preparing a fibroin protein solution with a concentration of 4-20%; (2) dissolving N-hydroxy succinimide in the fibroin protein solution in the step (1), uniformly stirring, standing, adding hirudin, and uniformly stirring to obtain a mixed solution; and (3) curing the mixed solution obtained from the step (2), adopting a methanol solution or an ethanol solution to carry out a dipping treatment, then soaking in deionized water, taking the obtained material, and carrying out air drying on the material to obtain the anticoagulation fibroin material. Compared with the fibroin material with no hirudin addition, the anticoagulation fibroin material of the present invention has the following advantages that: an anticoagulation performance is significantly increased, and hirudin in the anticoagulation fibroin material and activated fibroin protein can be directly subjected to stable covalent bonding through an amide bond so as to lastingly provide an anticoagulation effect.

The invention provides an anticoagulant fiber membrane and a preparation method and application thereof. The anticoagulant fiber membrane comprises a polyvinylidene fluoride membrane and a metal organic framework material with a carboxyl group, and the metal organic framework material with the carboxyl group is uniformly dispersed in the polyvinylidene fluoride membrane. The metal organic framework material in the anticoagulant fiber membrane can stably exist in a polyvinylidene fluoride membrane matrix. In addition, the anticoagulant fiber membrane has a good anticoagulant effect, and the result of the embodiment shows that the prothrombin time of the activated part of the anticoagulant fiber membrane is 42-60 seconds, and the anticoagulant effect is better. The anticoagulant fiber membrane has better hydrophilic properties, and the result of the embodiment shows that the contact angle between the anticoagulant fiber membrane and water is 50-80 degrees.

The invention relates to a small-caliber artificial blood vessel with the surface grafted with a heparin coating and a preparation method of the small-caliber artificial blood vessel. A small-caliberblood vessel is adopted as a substrate. The preparation method comprises the following steps: soaking the surface of the substrate in a dopamine solution for reaction, coating the surface of the substrate with multiple layers of polydopamine coatings, performing chemical bond combination grafting with polyethyleneimine, and finally activating heparin by utilizing 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS) to obtain the heparinized surface through amido bond combination. The invention has the characteristics of small caliber, favorable mechanical properties, hydrophilicity and long-acting anticoagulation; the preparation method is environmentally friendly and efficient in compounding, the prepared heparin coating is uniform, the grafting amount of heparin is higher and can reach 4.9 mu g / cm < 2 >, and good market application prospects are achieved.

The invention discloses an anticoagulation modification method for a hemodialyzer and an application thereof. The anticoagulation modification method for the hemodialyzer comprises the following steps: triggering polymerization cross-linking reaction of a uniform mixed reaction system of olefine acid monomer, sodium sulfonate monomer, cross-linking agent monomer, initiator and water under a protective atmosphere, thereby acquiring an active heparinoid aqueous solution; keeping the membrane silk inner surface of hemodialyzer in touch with the active heparinoid aqueous solution, and then separating; heating the hemodialyzer under an acidic condition and performing auto-agglutination cross-linking, thereby acquiring the hemodialyzer with high anticoagulation property. The hemodialyzer prepared according to the invention has excellent blood compatibility and high anticoagulation property; the anticoagulation modification technology is based on a water-base system in the whole process; during the whole modifying process, only the required heparinoid substances and water are introduced; the posttreatment, such as subsequent cleaning of membrane silk, is simple; the processing steps are simple, easy for operation and realization and easy for industrial production and popularization.

There are provided a polyol curable fluororubber composition using a fluororubber of general use, a cured fluororubber formed article used as a grommet, a seal packing and the like for a gas sensor which can be used under high temperature circumstances using this, and a method of producing the same. A polyol curable fluororubber composition, which comprises 100 parts by weight of a fluororubber, 6 to 15 parts by weight of magnesium oxide, 0.5 to 5 parts by weight of a hydrotalcite group compound and 20 to 55 parts by weight of a mixture of thermal black and a bituminous coal filler. A cured fluororubber formed article which is produced by forming and curing the fluororubber composition in the presence of a polyol curing agent, and then subjecting the cured formed product to a stepwise temperature elevation treatment in a temperature range of 100° C. to 300° C. According to the present invention, an article which can be used as a grommet, seal packing and the like for a gas sensor under high temperature circumstances, such as an oxygen sensor for an automobile, can be produced, at a reduced cost.

The invention belongs to the field of hollow fiber films, and especially relates to a blend polyvinylidene fluoride hollow fiber film used for hemodialysis, and a making method thereof. The method concretely comprises the following steps: blending dried polyvinylidene fluoride, polyvinylidene fluoride grafted polypropylene morpholide and argatroban copolymer, a pore forming agent and a cosolvent to prepare a film casting liquid; carrying out air bath on nascent hollow fibers formed after extruding the film casting liquid through a spinning head, allowing the obtained hollow fibers to enter a coagulation bath, coagulating and regenerating the hollow fibers, and reeling the hollow fibers to obtain a hollow fiber film; and immersing and cleaning the obtained hollow fiber film in pure water, taking out the cleaned hollow fiber film, and immersing the obtained hollow fiber film in a solution containing a pore keeping agent to obtain the finished blend modified polyvinylidene fluoride hollow fiber film. Blending is carried out to realize the hydrophilic modification purpose in order to finally improve the pollution resistance, the blood compatibility and the anticoagulant performance of the film. The hollow fiber film obtained in the invention has the advantages of high strength, high flux, good removal effect of toxic substances with a low molecular weight in blood, and wide application prospect.

The invention belongs to the technical field of membranes, and in particular relates to a modified polyvinylidene fluoride (PVDF) hollow fiber membrane for hematodialysisa, and a preparation method thereof. A PVDF body is modified by using acryloyl morpholine with rejecting performance on protein adsorption and cell adhesion and acrylic acid with high hydrophilic performance to prepare a hollow fiber membrane; the surface of the membrane is subjected to surface modification by L-arginine with an anticoagulation effect; and the anti-pollution performance, the blood compatibility and the anticoagulation performance of the membrane are finally improved, and a modified hollow fiber hemodialysis membrane with high biocompatibility and anticoagulation performance is obtained. The process provided by the invention is simple and can be applied to the field of hemodialysis.

The invention provides a venous retention needle suite with a hirudin anticoagulation tube sealing device, which comprises a casing, a transparent tee joint and a transfusion joint, wherein the casing is guided by a puncture needle and inserted into a vein; the transparent tee joint is connected to a built-in isolated sealing plug at the rear end of the casing; the transfusion joint is connected with a transfusion tube or a blood taking tube; the transparent tee joint is connected with the transfusion joint by an extension tube; the transfusion joint is sealed by a sealed end cap; one end of the transparent tee joint connected with the extension tube forms a double-cavity joint; one end of the double-cavity joint is connected with the extension tube, and the other end of the double-cavity joint is connected with a tube sealing device; and the tube sealing device comprises a liquid storing bag in a support and a roller which is arranged between the two side walls of the support and used for pushing the liquid in the liquid storing bag forwards. The venous retention needle suite with the hirudin anticoagulation tube sealing device can ensure that a tubular cavity of the retention needle is filled with the tube sealing liquid. The tube sealing liquid in the tube sealing device is hirudin diluent which has good anticoagulation effect and does not influence any index of serum test in blood.

This invention relates to a method for treating thrombosis by combined administration of a pitavastatin with aspirin.

The invention relates to biomedicines, which is a drug used for the treatment and prevention of thrombosis diseases, in particular to an application of sulfated polysaccharide in the preparation of anti-prothrombin activity drugs. The invention has the advantages that: the inulin sources are rich, the preparation conditions of sulfated inulin derivatives are easy to operate, and the invention is applicable to large-scale production; the anti-prothrombin effect is significant, the development prospect is broad and the significance is far-reaching.

A method of producing cross-linked rubber including a step of reacting a polyether rubber composition at 130 to 200° C., the polyether rubber composition containing 100 parts by weight of epihalohydrin monomer units, 0.1 to 100 parts by weight of a five-membered ring or six-membered ring nitrogen atom-containing aromatic heterocyclic type compound, and 0.1 to 10 parts by weight of at least one cross-linking agent which is selected from sulfur, a sulfur-containing compound, and triazine-based compound.

The invention belongs to the technical field of medical materials, and particularly relates to an inner and outer wall anti-infection and anti-coagulation indwelling needle hose and a preparation method thereof. According to the method, heparin sodium and polyurethane are grafted, then the grafted polyurethane is prepared into a coating liquid, an antibacterial agent is added into the coating liquid by a physical blending manner, and the surface of an indwelling needle hose is coated with the coating liquid by a dip-coating or spraying manner. The indwelling needle hose obtained by the methodhas good and long-lasting anti-infection and anti-coagulation performance, and can meet clinical application and realize wide application, and the preparation method of the indwelling needle hose is simple in process, obvious in effects, and easy to mass production.

The invention discloses an anticoagulation PVDF flat separation film, also discloses a making method of the anticoagulation PVDF flat separation film, and belongs to the technical field of films. The making method of the anticoagulation PVDF flat separation film comprises the following steps: 1, preparing a polyacrylic acid grafted polyvinylidene fluoride copolymer PVDF-g-PAA; 2, making a PVDF-g-PAA flat separation film; and 3, making an argatroban grafted and modified PVDF-ARG film. A PVDF film is modified by micro-molecular argatroban with a high efficiency anticoagulation effect with acrylic acid as a medium in order to obtain a PVDF separation film material with a good anticoagulation effect. The anticoagulation PVDF flat separation film can obviously prolong the recalcification time of the film, substantially reduces adhesion of platelet erythrocytes on the surface of the film, reduces the hemolysis rate, improves the anticoagulation performance and greatly improves the blood compatibility. The method has the characteristics of simple process and easy industrialization enforcement.

The invention relates to special flavor pork skin paste and a production method thereof and belongs to food processing technologies. Fresh pork skin or thawy quickly-frozen pork skin is subjected to cleaning, rinsing, impurity removal, peculiar smell removal and particle adjustment and then is subjected to softening and anticoagulation treatment. An appropriate amount of vegetable oil, soybean paste or flour paste and aromatic seasoning are added into softened and anti-coagulated pork skin, and paste type seasoning having special flavor and smooth and mellow taste is produced through flavor enhancing and cooking treatment. The production method changes the situation that existing pork skin only can be used in solid foods and chemical materials, improves the ductility and the spreadability of pork skin foods, enables products to be easily absorbed, enables the nutritive value to be improved and enables the seasoning to be delicious and tasty.

The invention discloses a scopoletin derivative as well as a preparation method and an application thereof. The general formula of the scopoletin derivative is formula (I), wherein R is selected from C1-4 alkyl and X is selected from a halo substituent. The scopoletin derivative has a remarkable anticoagulation effect and can remarkably prolong the in vitro blood coagulation time. The scopoletin derivative orally taken can quickly enter into blood to have the anticoagulation effect. The onset time and the curative effect of the scopoletin derivative for treating venous thromboembolic diseases are equivalent to those of warfarin and the scopoletin derivative is smaller in dosage and easy to control. The scopoletin derivative has novel medical use of preventing and treating venous thromboembolic diseases and meanwhile provides a novel treatment candidate medicine for patients with venous thromboembolic diseases. The invention further discloses the preparation method of the scopoletin derivative and the application of the scopoletin derivative in preparing anticoagulation medicines.

The invention discloses an anticoagulant dense net stent and a preparation method thereof. The stent comprises a dense net stent substrate and an organic small molecule coating bonded to the surface of the dense net stent substrate, and the thickness of the organic small molecule coating is 5-500 nm. When the stent is prepared, the dense-net stent substrate is cleaned, then the dense-net stent substraste is treated with a treating fluid, a titanium dioxide base layer is formed on the surface of the dense-net stent substrate, then the dense-net stent substrate is irradiated with ultraviolet rays, and finally the dense-net stent substrate subjected to ultraviolet irradiation is immersed in an organic small molecule acid solution, so that the stent is obtained after reacting for a certain time. The titanium dioxide-citric acid coating is constructed according to the anti-coagulation requirement of the dense net stent, and the coating can enable the dense net stent to be continuously anti-coagulated in the in-vivo service period, so that the postoperative anti-coagulation treatment dosage of a patient is reduced, and the economic pressure and psychological burden of the patient are reduced.

The invention discloses modified polycarbonate with high anticoagulant activity. Modified polycarbonate is a linear macromolecular polymer, wherein a side chain of the polymer contains functionalizeddouble bonds and hydrophilic phosphorylcholine groups. Modified polycarbonate comprises copolymers A, B and C. The preparation process of modified polycarbonate comprises the following steps: copolymerizing TMC (trimethylene carbonate) and a trimethylene derivative firstly, and then grafting the side chain of the copolymer with MPC (2-methacryloyloxyethyl phosphorylcholine) through a chick reaction of dithiol and the double bonds to obtain the target product modified polycarbonate with high anticoagulant activity. According to modified polycarbonate with high anticoagulant activity, performance of polycarbonate can be changed by adjusting monomer types and proportion and quantity of the phosphorylcholine groups on the side chain, and the anticoagulant capability of polycarbonate as a biodegradable medical polymer material can be improved; reaction sites can be provided by the double bonds on the side chain for follow-up grafting with biomacromolecules or other functional molecules, theresearch potential is high, and the derivative performance is wide.

A novel animal blood anticoagulant consisting of long-chain inorganic phosphates and organic phosphates. Wherein: the weight proportion of the long-chain inorganic phosphate and the organic phosphate is: the long-chain inorganic phosphate is 25-75 parts, and the organic phosphate is 25-75 parts. The method of using the above-mentioned novel animal blood anticoagulant is: dissolve the anticoagulant and water in a ratio of 1:10 (w / w) during use, and evenly sprinkle the anticoagulant solution in the blood tank before slaughtering, and then slaughter After the start, the anticoagulant solution is evenly sprayed on the surface of the original blood during the slaughtering process of the livestock and poultry, and the addition ratio of the anticoagulant solution to the original blood is 1:15-1:20 (v / v). Compared with traditional anticoagulants, the anticoagulant has stronger anticoagulant effect, can effectively inhibit hemolysis, reduces the amount of anticoagulant used, and significantly improves the anticoagulant effect of animal blood, which is beneficial to related Enterprise mass production.

The invention relates to a composite pig blood anticoagulant and a use method thereof. The composite pig blood anticoagulant comprises sodium citrate, ethylene diamine tetraacetic acid, sodium acetate and sodium chloride at the weight ratio of 6:4:1:3. Before being used, the composite pig blood anticoagulant needs to be dissolved into water, and each 56g of the pig blood anticoagulant needs to be dissolved into 1L of water, and correspondingly the mixture is added into 12kg of pig whole blood. The composite pig blood anticoagulant provided by the invention can ensure that pig blood does not be subjected to obvious clotting phenomenon within four days at normal temperature. The composite pig blood anticoagulant is simple in formula and convenient in operation, is economical and applicable, and can be used for effectively preventing the pig blood from clotting with reduced environmental pollution.

The invention relates to a tissue engineering nanofiber intravascular stent and a preparation method thereof. The stent consists of PLCL and a degradable polymer material, and has a nanofiber structure microcosmically, and the aperture is 5-10 microns. Preparation: dissolving the PLCL and a positively charged polymer in two different solvents to obtain homogeneous solutions, after dissolving completely, mixing two solution systems evenly, and performing electrostatic spinning by using a roller as a receiving device to obtain a nanofiber stent; and performing self-assembly modification by using a negatively charged degradable polymer as a surface modifier, washing by using deionized water, and drying to obtain a porous fiber stent. According to the tissue engineering nanofiber intravascular stent, the material is improved to improve the anticoagulant performance of the intravascular stent through performing self-assembly modification on a surface of the stent.

The invention discloses a hirudin anticoagulation tube sealing device for a venous retention needle, which comprises a sleeve, a transparent tee joint connected with the rear end of the sleeve, and a transfusion connector connected with a transfusion tube or a blood collecting tube; a connecting part connected with a tube sealing injector is arranged on the middle section of an extension tube; the tube sealing injector comprises a liquid tube in which a tube cavity is formed, a needle part connected with the front end of a sealed tube, and a shell which is sleeved outside the liquid tube and of which the rear end is sealed; a raised clamping wire is formed on the outer surrounding wall of the rear end of the liquid tube; a clamping groove is formed on the inner surrounding wall of the front end of the shell, and clamping steps at equal distance intervals are formed on the inner surrounding wall of the shell; and a sealing plug connected with the rear wall of the shell is arranged in the liquid tube. The hirudin anticoagulation tube sealing device for the venous retention needle can ensure the same amount of tube sealing liquid can be pushed in at each time and the tube sealing liquid can fully fill the tube cavity of the retention needle. The tube sealing liquid in the tube sealing injector is dilute solution of hirudin which has high anticoagulation effect and does not influence the test of the indexes of the serum in blood.