Inner and outer wall anti-infection and anti-coagulation indwelling needle hose and preparation method thereof

An anti-infection and anti-coagulation technology, applied in anti-coagulation treatment, needles, catheters, etc., can solve the complex process of compounding heparin and quaternary ammonium salts, the unstable anti-coagulation performance of indwelling needles, and the inability to meet high-performance medical devices. and other problems, to achieve the effects of long-lasting anti-infection and anti-coagulation performance, long-term stable anti-coagulation, and easy monitoring of grafting rate.

Inactive Publication Date: 2020-04-03
HENAN TUOREN BEST MEDICAL DEVICE CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Chinese patent Zl03116747.0 discloses a coating solution and a coating method for improving the anticoagulant performance on the surface of a biomedical device, which mainly utilizes a compound of heparin and a quaternary ammonium salt to prepare a coating solution; Chinese patent CN101966350A discloses a coating solution for The anticoagulant treatment method of medical polymer materials uses simple technical means to treat the heparin quaternary ammonium salt complex to achieve the purpose of anticoagulation; however, due to the limited molecular weight of the heparin and quaternary ammonium salt complex, it is easy to dissolve in the coating, At the same time, the compounding process of heparin and quaternary ammonium salts is complicated, and the heparin sodium is easily destroyed during the compounding process, which leads to the extremely unstable anticoagulant performance of the indwelling needle prepared by the above method, which is increasingly unable to meet the requirements of high-performance medical devices. need

Method used

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  • Inner and outer wall anti-infection and anti-coagulation indwelling needle hose and preparation method thereof
  • Inner and outer wall anti-infection and anti-coagulation indwelling needle hose and preparation method thereof
  • Inner and outer wall anti-infection and anti-coagulation indwelling needle hose and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] 1. Preparation of polyurethane membrane grafted with heparin sodium:

[0043] (a) Polyurethane membrane preparation

[0044] Dissolve polyether polyurethane pellets in tetrahydrofuran to obtain a polyurethane solution with a mass fraction of 5%, then pour the solution into glassware and dry it in an oven at 40°C to obtain a polyurethane film with a thickness of 0.05-0.1mm;

[0045] (b) Polyurethane membrane activation

[0046] Take 5g of the polyurethane film prepared above, add 100ml of KOH solution with a mass concentration of 10% and stir for 10h for hydrolysis. After the hydrolysis is completed, the polyurethane film is ultrasonically cleaned for 1h, and then 100ml of acetic acid solution is added to acidify for 10h under the condition of pH 4.0. After the acidification is completed, the polyurethane membrane is subjected to a second ultrasonic cleaning for 1 hour, and then the acidified polyurethane membrane that has been cleaned by the second ultrasonic cleaning ...

Embodiment 2

[0056] 1. Preparation of polyurethane membrane grafted with heparin sodium:

[0057] (a) Polyurethane membrane preparation

[0058] Dissolve polyether polyurethane pellets in tetrahydrofuran to obtain a polyurethane solution with a mass fraction of 5%, then pour the solution into glassware and dry it in an oven at 40°C to obtain a polyurethane film with a thickness of 0.05-0.1mm;

[0059] (b) Polyurethane membrane activation

[0060] Take 5g of the polyurethane film prepared above, add 100ml of KOH solution with a mass concentration of 10% and stir for 10h for hydrolysis. After the hydrolysis is completed, the polyurethane film is ultrasonically cleaned for 1h, and then 100ml of acetic acid solution is added to acidify for 10h under the condition of pH 4.0. After the acidification is completed, the polyurethane membrane is subjected to a second ultrasonic cleaning for 1 hour, and then the acidified polyurethane membrane that has been cleaned by the second ultrasonic cleaning ...

Embodiment 3

[0070] 1. Preparation of polyurethane membrane grafted with heparin sodium:

[0071] (a) Polyurethane membrane preparation

[0072] Dissolve polyether polyurethane pellets in tetrahydrofuran to obtain a polyurethane solution with a mass fraction of 5%, then pour the solution into glassware and dry it in an oven at 40°C to obtain a polyurethane film with a thickness of 0.05-0.1mm;

[0073] (b) Polyurethane membrane activation

[0074] Take 5g of the polyurethane film prepared above, add 100ml of KOH solution with a mass concentration of 10% and stir for 10h for hydrolysis. After the hydrolysis is completed, the polyurethane film is ultrasonically cleaned for 1h, and then 100ml of acetic acid solution is added to acidify for 10h under the condition of pH 4.0. After the acidification is completed, the polyurethane membrane is subjected to a second ultrasonic cleaning for 1 hour, and then the acidified polyurethane membrane that has been cleaned by the second ultrasonic cleaning ...

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Abstract

The invention belongs to the technical field of medical materials, and particularly relates to an inner and outer wall anti-infection and anti-coagulation indwelling needle hose and a preparation method thereof. According to the method, heparin sodium and polyurethane are grafted, then the grafted polyurethane is prepared into a coating liquid, an antibacterial agent is added into the coating liquid by a physical blending manner, and the surface of an indwelling needle hose is coated with the coating liquid by a dip-coating or spraying manner. The indwelling needle hose obtained by the methodhas good and long-lasting anti-infection and anti-coagulation performance, and can meet clinical application and realize wide application, and the preparation method of the indwelling needle hose is simple in process, obvious in effects, and easy to mass production.

Description

technical field [0001] The invention belongs to the technical field of medical materials, and in particular relates to an anti-infection and anti-coagulation indwelling needle hose with inner and outer walls and a preparation method thereof. Background technique [0002] The indwelling needle has the advantages of multiple administrations, regular administration, large infusion volume, and long infusion time. Therefore, the use of intravenous indwelling for infusion has gradually replaced the traditional frequent puncture infusion. It can not only stay in the vein for a long time It not only reduces the workload of medical staff, but also reduces the pain caused by frequent puncture of patients. [0003] However, looking at the current existing indwelling needles, there are still some problems while providing convenience, such as frequent blockages in the use process, skin allergies, phlebitis, etc.; and most of them are due to the indwelling needle hose Contact with blood ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/158A61L29/08A61L29/16A61L33/10
CPCA61L29/085A61L29/16A61L33/0011A61L33/0076A61L33/08A61L2300/404A61L2300/406A61L2300/606A61M5/158A61M2005/1586A61M2205/0205A61M2205/0238C08L75/08C08L5/10C08L71/02C08L39/06
Inventor 张鹏超崔景强刘秋华王国锋刘志远牛利卫李发坤华静宇夏凯丽
Owner HENAN TUOREN BEST MEDICAL DEVICE CO LTD
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