Modified polyvinylidene fluoride hollow fiber membrane for hematodialysis

A technology of polyvinylidene fluoride and hemodialysis, applied in dialysis systems, semi-permeable membrane separation, membranes, etc., can solve the problems of poor effect, compatibility and anticoagulation, and achieve the best hemocompatibility Effects of stability, low platelet adhesion and hemolysis rate, and good biocompatibility

Inactive Publication Date: 2017-01-11
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Aiming at the problem that the existing PVDF hollow fiber membrane is incompatible with blood and has poor anticoagulant effect, the present invention provides a modified polyvinylidene fluoride hollow fiber membrane for hemodialysis and its preparation Method, the preparation method of the membrane is simple, and the reusability is high. The obtained hollow fiber membrane has the characteristics of high strength and high flux, and has a good removal effect on toxic substances of medium and low molecular weight in blood, and can be used in the field of hemodialysis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Example 1: A modified polyvinylidene fluoride hollow fiber membrane and its preparation method

[0038] (1) Preparation of polyvinylidene fluoride grafted polyacryloylmorpholine and acrylic acid copolymer:

[0039] Add PVDF powder with a final concentration of 100g / L to 2.5mol / L potassium hydroxide solution, and add absolute ethanol to the above alkali solution at a rate of 10mL / L, and stir in a constant temperature water bath at 100°C for 5 minutes. . The resulting product was suction filtered, and the PVDF powdery solid product obtained after washing with pure water was put into an oven at 60° C. for drying.

[0040] Add 16g of the above alkali-treated PVDF powder into a three-necked flask containing 120g DMF to prepare a homogeneous solution, then add 0.2g of AIBN, and then add ACMO monomer according to the molar ratio of ACMO:AA:PVDF of 1:1:2 React with AA monomer under the protection of nitrogen atmosphere at 50°C for 24 hours. The solution after reaction is prec...

Embodiment 2

[0048] Example 2: A modified polyvinylidene fluoride hollow fiber membrane and its preparation method

[0049] (1) Preparation of polyvinylidene fluoride grafted polyacryloylmorpholine and acrylic acid copolymer:

[0050] Add PVDF powder with a final concentration of 180g / L to 10mol / L sodium hydroxide solution, and add absolute ethanol to the above alkali solution at a rate of 30mL / L, and stir and react in a constant temperature water bath at 50°C for 20 minutes. The resulting product was suction filtered, and the PVDF powdery solid product obtained after washing with pure water was put into an oven at 60° C. for drying.

[0051] Add 16g of the above alkali-treated PVDF powder into a three-necked flask containing 80g DMSO to prepare a homogeneous solution, then add 1.6g of AIBN, and then add ACMO monomer according to the molar ratio of ACMO:AA:PVDF of 1:1:4 React with AA monomer under the protection of nitrogen atmosphere at 70°C for 12 hours. The solution after reaction is p...

Embodiment 3

[0059] Example 3: A modified polyvinylidene fluoride hollow fiber membrane and its preparation method

[0060] (1) Preparation of polyvinylidene fluoride grafted polyacryloylmorpholine and acrylic acid copolymer:

[0061] Add PVDF powder with a final concentration of 180g / L to 5mol / L sodium hydroxide solution, and add absolute ethanol to the above alkali solution at a rate of 10mL / L, and stir and react in a constant temperature water bath at 60°C for 10 minutes. The resulting product was suction filtered, and the PVDF powdery solid product obtained after washing with pure water was put into an oven at 60° C. for drying.

[0062] Add 16g of the above alkali-treated PVDF powder into a three-necked flask containing 240g of DMAC to prepare a homogeneous solution, then add 0.8g of EDC, and then add ACMO monomer at a molar ratio of ACMO:AA:PVDF of 1:1:2 React with AA monomer under the protection of nitrogen atmosphere at 70°C for 12 hours. The solution after reaction is precipitate...

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Abstract

The invention belongs to the technical field of membranes, and in particular relates to a modified polyvinylidene fluoride (PVDF) hollow fiber membrane for hematodialysisa, and a preparation method thereof. A PVDF body is modified by using acryloyl morpholine with rejecting performance on protein adsorption and cell adhesion and acrylic acid with high hydrophilic performance to prepare a hollow fiber membrane; the surface of the membrane is subjected to surface modification by L-arginine with an anticoagulation effect; and the anti-pollution performance, the blood compatibility and the anticoagulation performance of the membrane are finally improved, and a modified hollow fiber hemodialysis membrane with high biocompatibility and anticoagulation performance is obtained. The process provided by the invention is simple and can be applied to the field of hemodialysis.

Description

[0001] Technical field: [0002] The invention belongs to the technical field of membranes, and in particular relates to a modified polyvinylidene fluoride hollow fiber membrane used for hemodialysis and a preparation method thereof. [0003] Background technique: [0004] At present, the hollow fiber membrane material used in hemodialysis is regarded as a foreign body in the body. When it comes into contact with blood, it will inevitably cause a series of defense reactions in the body. Among them, platelet adhesion, activation of the coagulation system, and generation of coagulation and thrombus are the most important. severe reaction. Polyvinylidene fluoride (PVDF) is a polymer material with excellent performance. Its outstanding chemical stability, radiation resistance and heat resistance make it widely used in the field of membrane separation. The PVDF membrane material has a smooth surface, low surface energy, and the material itself is non-toxic. The flux of the prepared...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D69/02B01D71/34B01D67/00A61M1/18
CPCA61M1/16B01D67/0006B01D69/02B01D69/08B01D71/34B01D2323/38
Inventor 陈莉安子韩赵义平
Owner TIANJIN POLYTECHNIC UNIV
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