Hollow fiber ultrafiltration composite membrane, preparation method and application thereof
A technology of ultrafiltration composite membrane and hollow fiber, which is applied in the direction of chemical instruments and methods, membrane technology, semipermeable membrane separation, etc., can solve the problems of increasing activation degree and affecting the biocompatibility of polysulfone membrane materials, and achieve reduction Stimulation, improved blood compatibility, low complement activating factor effects
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[0017] The hollow fiber ultrafiltration composite membrane of the present invention is composed of components having the following weight percentages: 15-25% membrane material, 5-15% porogen, 55-75% organic solvent and 5-10 % Lithium chloride, the membrane material is a mixture of polysulfone, polyethersulfone, polyacrylonitrile, polymethyl methacrylate or cellulose triacetate and 1-5% chitosan. The viscosity average molecular weight of the chitosan of the present invention is between 300,000 and 1,000,000. The viscosity average molecular weight of the chitosan is preferably controlled between 500,000 and 800,000. The chitosan N-deacetylation degree is between 60% and 100%. The organic solvent of the present invention It is one of N-methyl-2-pyrrolidone, dimethylacetamide or dimethyl sulfoxide, and the porogen is one of polyvinylpyrrolidone, polyethylene glycol and polyvinyl alcohol or a mixture of any two of them , The above-mentioned raw materials are all commercially availab...
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