228results about How to "Reduce coagulation" patented technology

A system for diagnosis or treatment of tissue in a body is provided. The system includes an ablation catheter having a deformable, elongate shaft having proximal and distal ends. The catheter further includes an ablation delivery member disposed proximate the distal end of the shaft and configured to deliver ablation energy to ablate the tissue. In one embodiment, the ablation delivery member comprises an ablation electrode and may also be configured to generate a signal indicative of electrical activity in the tissue. The catheter further includes one or more sensing electrodes disposed proximate the ablation delivery member. The sensing electrodes are configured to generate signals indicative of electrical activity in the tissue. The system further includes an electronic control unit configured to control delivery of ablation energy from the ablation delivery member responsive to one or more of the generated signals indicative of electrical activity in the tissue.

A blood pump has an impeller rotatably disposed and magnetically suspended within a cavity of a stator by a plurality of magnetic bearings (passive permanent and active electromagnetic) having impeller magnets on the impeller and stator magnets or coils/poles on the stator. A motor includes impeller magnets on the impeller and coils/poles associated with the stator. A single, annular blood flow path extends axially through the cavity between the impeller and the stator, and between the impeller magnets on the impeller and the stator magnets or the coils/poles on the stator.

A removable filter for capturing thrombi in a body vessel. The filter has anti-thrombogenic, echogenic, and radiopaque features. The features of the filter provide for enhanced identifying and reduced endotheliosis in a body vessel of a patient. Generally, the anti-thrombogenic feature is preferably a fibrinolytic coating disposed on the filter to decrease the accumulation of fibrin thereon. The echogenic feature preferably is comprised of marks formed on the filter that give rise to reflections of ultrasound waves during ultrasonography. The radiopaque feature is preferably a polymeric coating, ceramic coating, or noble metal coating applied on the filter for enhanced fluoroscopy.

The invention discloses a method for transforming fatty acid ethyl ester into glyceride, which comprises the following steps of: mixing the fatty acid ethyl ester and glycerol in a material tank; making the material pass through a glycerol separator by using a pump to separate free glycerin; then putting the material in a reactor in which immobilized lipase is filled; and making the material passthrough a packed tower to remove ethanol; making the material finally flow back to the material tank for performing 6 to 300h circular reaction; then carrying out molecular distillation on the reaction product to remove the unconverted reactant so as to obtain glyceride products. The method can improve the stability and bioavailability of the products, and has high application value for transforming functional fatty acids such as ethyl ester fish oil, algae oil, conjugated linoleic acid, arachidonic acid and the like into glyceride products.

The invention concerns a composite support comprising a base support for the treatment of a biological fluid, in which: “the base support is essentially-constituted by a first polymer carrying anionic or anionizable groups;” at least a part of the surface of the base support is coated with a second polymer ionically bonded to the first polymer, the second polymer carrying the cationic or cationizable groups which are capable of forming an ionic bond with the anionic or anionizable groups of the first polymer; in which the second polymer is in the colloidal form and in mixture with a polyacid during application to the support, allowing the composite membrane to adsorb at least one entity containing anionic or anionizable groups by bonding with cationic or cationizable groups of the second polymer.

Disclosed is a catheter having a flexible tube and a sharpened needle secured to the catheter at its distal end. The catheter does not require a separate sharpened instrument to enable insertion into an anatomical passageway. The sharpened needle of the catheter remains disposed within an anatomical passageway during treatment. Also disclosed is a catheter assembly comprising the catheter and a safety inserter. The safety inserter has a blunt end and facilitates the insertion of the catheter by providing a mechanism to urge the sharpened needle of the catheter into an anatomical passageway. Also disclosed is an improved needle tip which minimizes trauma to an anatomical passageway. Also disclosed are methods of using and forming the catheter, catheter assembly and needle tip.

The invention relates to a graphene high temperature resistant corrosion-resistant coating for a metallic material and a preparation method of the graphene high temperature resistant corrosion-resistant coating. The graphene high temperature resistant corrosion-resistant coating consists of the following components in parts by weight: 6-12 parts of graphene oxide, 20-45 parts of a phenolic resin,2-6 parts of polyvinyl butyral, 1-4 parts of rare earth chloride, 12-30 parts of graphene quantum dots, 2-5 parts of a heat conduction metallic powder, 3-6 parts of carbon nanotubes, 12-30 parts of asolvent, 2-6 parts of an antioxidant, 5-9 parts of a curing agent and 12-18 parts of a defoaming agent, wherein the graphene quantum dots is 2-4nm in size; the solid content of the phenolic resin is 45-55%. According to the graphene high temperature resistant corrosion-resistant coating provided by the invention, by the virtue of the good dispersibility of the graphene quantum dots in solvents andrelatively good non-covalent functions of the graphene quantum dots with graphene sheets, two-dimensional sheet structures of the graphene can be overlapped layer by layer in the coating, a compact physical insulating layer can be formed, and the corrosion resistance of the coating can be improved.

A method of precipitating a poly(arylene ether) includes preparing a poly(arylene ether) solution comprising a poly(arylene ether) and a solvent, combining the poly (arylene ether) solution with an antisolvent to form a poly(arylene ether) dispersion comprising a poly(arylene ether) solid, separating the poly(arylene ether) solid from the poly(arylene ether) dispersion to form an isolated poly(arylene ether) solid, determining a particle size distribution of the poly(arylene ether) solid prior to separating the poly(arylene ether) solid from the poly(arylene ether) dispersion, and adjusting a precipitation parameter in response to the particle size distribution. Although the measured particle size distribution is very different from the particle size distribution of the solid poly(arylene ether) ultimately isolated, it is useful for controlling the process. The method may be automated to rapidly adjust precipitation conditions in response to the particle size distribution measurements. An apparatus for carrying out the method is also described.

The invention discloses a bioprosthetic valve with anticoagulation and anti-calcification functions and a preparation method thereof. The method comprises the following steps: carrying out cross-linking treatment on a biological valve by adopting glutaraldehyde, and carrying out modification treatment by adopting hydrophilic molecules or hydrophobic molecules after cross-linking; or performing modification treatment on the biological valve by hydrophilic molecules or hydrophobic molecules, and then carrying out crosslinking treatment by glutaraldehyde; or performing at least one time of modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules, then performing cross-linking treatment by glutaraldehyde, and finally performing at least one timeof modification treatment on the biological valve by adopting hydrophilic molecules or hydrophobic molecules. The biological valve prepared by the preparation method disclosed by the invention not only has good mechanical properties, but also has excellent anticoagulation and anti-calcification effects.

A method of making a blood pump comprises selecting a desired flow pattern in a pumping chamber defined by an extensible bladder wherein the flow pattern is based generally on blood flow in a natural heart, using an initial computer model of the desired flow pattern to determine the material composition and dynamic operation conditions of each portion of the bladder, designing a bladder and pump operating system, computer modeling the actual design, testing and refining the design, and constructing a prototype based thereon. The desired flow pattern includes guiding and directing the flow of blood through the pumping chamber by reason of the action of an expansile bladder on the blood flow. A continuous circular or spiral fluid path is obtained that more effectively washes all areas of the bladder including the inlet and discharge ports with blood to reduce thrombosis.

Described herein are engineered microbe-targeting or microbe-binding molecules, kits comprising the same and uses thereof. The microbe-targeting or microbe-binding molecules can comprise a microbe surface-binding domain linked to a portion of an Fc region. Further, the microbe-targeting molecules can be conjugated to substrate (e.g., a magnetic particle) to form a microbe-targeting substrate. Such microbe-targeting molecules and/or substrates and the kits comprising the same can be used in various applications, such as diagnosis and/or treatment of an infection caused by microbes. Moreover, the microbe-targeting molecules and/or substrates can be easily regenerated after use.

Provided herein are improved compositions comprising lactoferrin and methods for modulating T cell subtypes and their activities in a subject, to improve the balance between anti-inflammatory (Th2) cytokine producing cells and pro-inflammatory (Th1) or Th17 cells, and skew naïve T cells toward a pro-regulatory phenotype, for the treatment and/or amelioration of neurodegen erative or autoimmune diseases and disorders (e.g., inflammatory bowel disease (IBD), amyotrophic lateral sclerosis (ALS), Alzheimers disease, cognitive decline in the elderly resulting from chronic inflammation, and/or rheumatoid arthritis (RA)).

A spray dispenser is configured to generate a swirled output spray pattern 152 with improved rotating or angular velocity ω and smaller sprayed droplet size. Cup-shaped nozzle member 60 has a cylindrical side wall 62 surrounding a central longitudinal axis 64 and has a circular closed end wall 68 with at least one exit aperture 74 passing through the end wall. At least one enhanced swirl inducing mist generating structure is formed in an inner surface 70 of the end wall, and including a pair of opposed inwardly tapered offset power nozzle channels 80, 82 terminating in an interaction chamber 84 surrounding the exit aperture 74. The power nozzle channels generate opposing offset flows which are aimed to very efficiently generate a vortex of fluid which projects distally from the exit aperture as a swirled spray of small droplets 152 having a rapid angular velocity.

The invention provides a method for preparing mesophase carbon microspheres with an emulsification-hydrogenation-thermal polymerization ternary coupled system and belongs to the technical field of preparation of mesophase carbon microspheres. The method comprises steps as follows: 1) an emulsification-hydrogenation-thermal polymerization ternary coupled solvent system is prepared from a hydrogen supply solvent, a modification catalyst and an emulsification solvent; 2) medium and low temperature coal tar asphalt with the fraction larger than 300 DEG C is added to the emulsification-hydrogenation-thermal polymerization ternary coupled solvent system, and mesophase asphalt is prepared; 3) the mesophase asphalt is subjected to extraction with an organic solvent, dried, pre-oxidized in the airatmosphere, carbonized in an N2 atmosphere and graphitized, and mesophase carbon microspheres are obtained. The preparation method of the mesophase carbon microspheres is a brand-new one-pot emulsification system, a good production environment is provided for growth of the mesophase carbon microspheres, and good sphericity degree, smooth surfaces, uniform size distribution and high graphitizationdegree of the prepared mesophase carbon microspheres are guaranteed.

The invention provides an antibacterial and anticoagulant coating. The antibacterial and anticoagulant coating comprises an organosilicon quaternary ammonium salt heparin compound; the organosilicon quaternary ammonium salt heparin compound is obtained after heparin sodium and organosilicon quaternary ammonium salt react; and the organosilicon quaternary ammonium salt includes a structure shown asa formula (I) (please see the specifications for the formula (I)). Siloxane groups of the organosilicon quaternary ammonium salt in the coating can be in chemical bond connection with heparin sodiummolecules and the surface of a hydroxylated matrix material correspondingly, heparin and the organosilicon quaternary ammonium salt in the coating are mutually crosslinked to form a three-dimensionalnetwork structure, the stability of the coating is improved, meanwhile, the coating and a coated base body are subjected to cross-linking point type chemical bond cross-linking, the stability of the coating and the coated base body is greatly improved, thus dissociation and falling of the coating in the intervening, using and indwelling processes of a medical catheter are avoided, and the anticoagulant and antibacterial effects are more durable. In addition, the coating can be formed only by adopting a heating curing mode, the process is simpler, operation is easy, and feasibility is high.

The invention discloses a preparation method of a wear-resisting ceramic tile capable of releasing a negative ion. A finished product of the ceramic tile is obtained by ball-milling a powder material,pulping, spraying a powder, forming, biscuiting, glazing, glaze-firing and edging; a used glaze comprises a negative ion powder; the powder material comprises potassium feldspar, albite, nepheline, kaolin, washing mud, barium carbonate, calcined talcum, nano-zinc oxide, methylcellulose, sodium tripolyphosphate, a preservative. The preparation method adopts the low-temperature biscuiting and high-temperature glaze-firing process; the ceramic tile produces a large quantity of negative ions, the glaze is flat and smooth, the resistance to thermal shock and the stain resistance are good, and thepreparation method has excellent performances of wear resistance and acid corrosion resistance, and has excellent economic and social benefits.

There are provided a release agent capable of attaining a toner excellent in an anti-offset property and an anti-filming property, without detaching from a kneaded mass even in a case of granulating by heating a dispersion medium containing the kneaded mass, as well as a toner using the release agent and a manufacturing method thereof. A release agent containing a compatible site having compatibility with the binder resin and a releasing site chemically bonded with the compatible site and having the releasing ability is used as the release agent when preparing a kneaded mass by melt-kneading at least a binder resin, a colorant, and a release agent, whereby detachment of the release agent from the kneaded mass can be prevented in producing particles of kneaded mass as the toner particles by mixing the kneaded mass to an aqueous medium prepared and heating and stirring them.