Preparation method and application of carbonized resin grafted with arginine

By synthesizing and carbing the resin in the blood perfusion adsorption material and grafting arginine on its surface, the problem of insufficient blood compatibility of the resin is solved, significantly improving the biocompatibility and adsorption performance, especially in removing creatinine and Uric acid shows higher efficiency.

CN119075941APending Publication Date: 2024-12-06HEBEI LIJIANG BIOTECHNOLOGY CO LTD
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Patent Information

Application Number
CN202411350503.1
Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
Filing Date
2024-09-26
Publication Date
2024-12-06

AI Technical Summary

Technical Problem

The resin of existing blood perfusion adsorbent materials is insufficient in blood compatibility when in contact with blood, which can easily cause coagulation and hemolysis, and cannot effectively remove toxic substances such as creatinine and uric acid in the blood.

Method used

Diethylene benzene and triallyl isocyanurate as composite crosslinking agents to synthesize polystyrene macroporous resins, and carbonized resins are formed through carbonization treatment to increase their strength and pore structure uniformity, and then the resin surface is Polyhydroxyethyl methacrylate envelope treatment was performed, and finally arginine was grafted on the surface of the resin to improve biocompatibility.

Benefits of technology

It significantly improves the biocompatibility of the resin, reduces the occurrence of coagulation and hemolytic side reactions, and increases the adsorption rate and adsorption amount to water-soluble toxins such as creatinine and uric acid.

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Abstract

The invention discloses a preparation method and application of carbonized resin grafted with arginine, and belongs to the technical field of adsorption resin. The method comprises the following steps: (1) preparing a water phase; (2) preparing an oil phase; (3) synthesizing resin white balls; (4) carbonizing the resin; (5) coating with resin; and (6) grafting arginine. The arginine-grafted carbonized resin disclosed by the invention has good biocompatibility and the performance of adsorbing creatinine and uric acid.
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Citation Information

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