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Biological polysaccharide derivative self-assembled and photochemical cross-linking modified polyurethane material and preparation method thereof

A technology of polyurethane materials and biological polysaccharides, applied in medical science, coatings, prostheses, etc., can solve the problems of the stability of the surface modification layer, the time-consuming chemical cross-linking reaction, and unfavorable biological activity, etc., to improve blood compatibility Non-toxic, good biodegradability, simple process effect

Inactive Publication Date: 2011-11-16
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the layer-by-layer self-assembly technology utilizes the electrostatic force between polyelectrolytes, so when the layer-by-layer self-assembled surface-modified biomedical materials are implanted in the body, the stability of the surface modification layer is often affected by the complex body fluids in the body. environmental impact
Some researchers used chemical methods to cross-link the layer-by-layer self-assembled multilayer film to improve the stability and hardness of the surface self-assembled multilayer film, although the stability of the self-assembled multilayer film after crosslinking has certain The degree of improvement, but the chemical cross-linking reaction takes a long time, and a film with a thickness of 1 μm needs to be cross-linked for several hours [Langmuir, 2006, 22: 1193-1200]
In addition, the use of chemical cross-linking reagents tends to adversely affect the biological activity of modified components such as biomacromolecules in the surface modification layer

Method used

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  • Biological polysaccharide derivative self-assembled and photochemical cross-linking modified polyurethane material and preparation method thereof
  • Biological polysaccharide derivative self-assembled and photochemical cross-linking modified polyurethane material and preparation method thereof
  • Biological polysaccharide derivative self-assembled and photochemical cross-linking modified polyurethane material and preparation method thereof

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Embodiment 1

[0037] A preparation method of a polyurethane material modified by self-assembly of biological polysaccharide derivatives and photochemical cross-linking, comprising the following specific steps:

[0038] 1) Preparation of lentinan derivative - lentinan sulfate:

[0039] Add 0.6 g of lentinan into a reaction vessel containing 50 mL of dimethyl sulfoxide, stir at 20 ° C for 12 hours, and then slowly dropwise add 9 mL of pyridine at a rate of 2 mL / min, continue stirring for 30 minutes, and then react The container was placed in an ice bath, and 3.7 mL of chlorosulfonic acid was slowly added dropwise with a constant pressure funnel at a rate of 0.5 mL / min under stirring. At room temperature, the pH was adjusted to neutrality with a 5wt% NaOH solution, and then the obtained reaction solution was injected into a regenerated cellulose dialysis bag, dialyzed in a NaOH solution with a pH of 10 for 12 hours, and then dialyzed with tap water for 4 days. Deionized water was dialyzed for...

Embodiment 2

[0062] A preparation method of a polyurethane material modified by self-assembly of biological polysaccharide derivatives and photochemical cross-linking, comprising the following specific steps:

[0063] 1) Preparation of lentinan derivative - lentinan sulfate:

[0064] 1.2 g of lentinan was added to a reaction vessel containing 100 mL of dimethyl sulfoxide, stirred at 20°C for 12 hours, and then slowly added dropwise 18 mL of pyridine at a rate of 4 mL / min, continued stirring for 30 minutes, and then the reaction was carried out. The container was placed in an ice bath, and 7.4 mL of chlorosulfonic acid was slowly added dropwise with a constant pressure funnel at a speed of 1 mL / min under stirring. , adjust the pH to neutrality with a 5wt% NaOH solution, and then inject the obtained reaction solution into a regenerated cellulose dialysis bag, dialyze it in a NaOH solution with a pH of 10 for 12 hours, and then dialyze it with tap water for 4 days. Ionized water was dialyzed...

Embodiment 3

[0082]A preparation method of a polyurethane material modified by self-assembly of biological polysaccharide derivatives and photochemical cross-linking, comprising the following specific steps:

[0083] 1) Preparation of lentinan derivative - lentinan sulfate:

[0084] Add 0.6 g of lentinan to a reaction vessel containing 50 mL of dimethyl sulfoxide, stir at 30 ° C for 18 hours, and then slowly dropwise add 9 mL of pyridine at a rate of 4 mL / min, continue stirring for 40 minutes, and then react The container was placed in an ice bath, and 3.7 mL of chlorosulfonic acid was slowly added dropwise with a constant pressure funnel at a rate of 1.0 mL / min under stirring. At room temperature, the pH was adjusted to neutrality with a 10wt% NaOH solution, and then the obtained reaction solution was injected into a regenerated cellulose dialysis bag, dialyzed in a NaOH solution with a pH of 10 for 18 hours, and then with tap water for 6 days. Deionized water was dialyzed for 5 days, th...

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Abstract

The invention relates to a preparation method of a biological polysaccharide derivative self-assembled and photochemical cross-linking modified polyurethane material. The biological polysaccharide derivative self-assembled and photochemical cross-linking modified polyurethane material is characterized by being composed of a substrate and modified layers, wherein the substrate is made of the polyurethane material, the modified layers are obtained by self-assembling the biological polysaccharide derivatives layer by layer on the surface of the substrate, and then modifying the surface by photochemical cross-linking reaction, and the modified layers contain two biological polysaccharide derivatives, namely a lentinan derivative and a chitosan derivative self-assembled layer by layer on the surface of the substrate and photochemically cross-linked. The surface of the polyurethane material has favorable hydrophilicity and favorable antibacterial activity on inhibiting escherichia coli, the blood compatibility of the surface of the polyurethane material is also improved, and the preparation method of the polyurethane material is more simple and easy to control, and has quick reaction, mild preparation conditions and lower cost.

Description

technical field [0001] The invention belongs to the technical fields of biomedical materials, polymer chemistry, photochemical reaction and molecular self-assembly, in particular to a preparation method of a polyurethane material modified by self-assembly of biological polysaccharide derivatives and photochemical cross-linking. Background technique [0002] Due to its excellent physical and mechanical properties and good biocompatibility, polyurethane materials have a huge role in the manufacture of various devices implanted in the human body, such as artificial heart valves, artificial dialysis membranes, artificial blood vessels and other biomedical polymer materials. application prospects. Due to its strong resistance to biological aging, stable physical and chemical properties, and easy processing and molding, medical polymer materials have become the most widely used and used variety of biomedical materials, and the demand has grown rapidly in recent years. However, wh...

Claims

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Application Information

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IPC IPC(8): C08J7/12C08L75/04C08B37/00C08B37/08C08J5/18C08J3/28C08J3/24A61L27/18A61L27/34
Inventor 王艺峰姚祥雨陈艳军熊燕飞吴仲岿
Owner WUHAN UNIV OF TECH
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