Anticoagulant dense net stent and preparation method thereof

An anti-coagulation and dense mesh technology, applied in the field of anti-coagulation dense mesh stent and its preparation, can solve the problems of thrombus restenosis, vascular intima damage, occlusion, etc., and achieve easy control, inhibition of adhesion and activation , good anticoagulant effect

Active Publication Date: 2021-08-27
成都百瑞恒通医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Aiming at the above-mentioned prior art, the present invention provides an anticoagulant dense-mesh stent and a preparation method thereof, so as to solve the problem that the extrusion of the existing dense-mesh stent to the vessel wall after implantation easily leads to damage to the intima of the blood vessel, thereby inducing thrombus cause restenosis or even occlusion

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  • Anticoagulant dense net stent and preparation method thereof
  • Anticoagulant dense net stent and preparation method thereof
  • Anticoagulant dense net stent and preparation method thereof

Examples

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Effect test

Embodiment 1

[0033] An anticoagulant dense-mesh stent comprises a nickel-titanium alloy dense-mesh stent base and a citric acid coating bonded to the surface of the nickel-titanium alloy dense-mesh stent base, and the thickness of the citric acid coating is about 300nm.

[0034] The dense-mesh scaffold for promoting endothelialization in this example was prepared through the following steps:

[0035] S1: Place the base of the dense-mesh stent in deionized water, and ultrasonically clean it three times, each time for 5 minutes; then place it in absolute ethanol, and ultrasonically clean it three times, each time for 5 minutes; then place it in acetone, and ultrasonically clean it three times, each time for 5 minutes ; Dry in a vacuum oven at last;

[0036] S2: Submerge the nickel-titanium alloy dense-mesh stent substrate treated by S1 in the treatment solution at a temperature of 50°C, and adjust the pH of the treatment solution to 3.88 with hydrofluoric acid, and take out the dense-mesh st...

Embodiment 2

[0040] An anticoagulant dense-mesh stent comprises a nickel-titanium alloy dense-mesh stent base and an acetylsalicylic acid coating bonded to the surface of the nickel-titanium alloy dense-mesh stent base, and the thickness of the acetylsalicylic acid coating is about 500nm.

[0041] The dense-mesh scaffold for promoting endothelialization in this example was prepared through the following steps:

[0042] S1: Place the base of the dense-mesh stent in deionized water, and ultrasonically clean it three times, each time for 5 minutes; then place it in absolute ethanol, and ultrasonically clean it three times, each time for 5 minutes; then place it in acetone, and ultrasonically clean it three times, each time for 5 minutes ; Dry in a vacuum oven at last;

[0043] S2: Submerge the nickel-titanium alloy dense-mesh stent substrate treated by S1 in the treatment solution at a temperature of 45°C, and adjust the pH of the treatment solution to 3.5 with hydrofluoric acid, and take out...

Embodiment 3

[0047] An anticoagulant dense-mesh support includes a nickel-titanium alloy dense-mesh support base and a tannic acid coating bonded to the surface of the nickel-titanium alloy dense-mesh support base. The thickness of the tannic acid coating is about 100nm.

[0048] The dense-mesh scaffold for promoting endothelialization in this example was prepared through the following steps:

[0049] S1: Place the base of the dense-mesh stent in deionized water, and ultrasonically clean it three times, each time for 5 minutes; then place it in absolute ethanol, and ultrasonically clean it three times, each time for 5 minutes; then place it in acetone, and ultrasonically clean it three times, each time for 5 minutes ; Dry in a vacuum oven at last;

[0050]S2: Immerse the nickel-titanium alloy dense-mesh stent substrate treated by S1 in the treatment solution at a temperature of 55°C, adjust the pH of the treatment solution to 4.0 with hydrofluoric acid, and take out the dense-mesh stent su...

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Abstract

The invention discloses an anticoagulant dense net stent and a preparation method thereof. The stent comprises a dense net stent substrate and an organic small molecule coating bonded to the surface of the dense net stent substrate, and the thickness of the organic small molecule coating is 5-500 nm. When the stent is prepared, the dense-net stent substrate is cleaned, then the dense-net stent substraste is treated with a treating fluid, a titanium dioxide base layer is formed on the surface of the dense-net stent substrate, then the dense-net stent substrate is irradiated with ultraviolet rays, and finally the dense-net stent substrate subjected to ultraviolet irradiation is immersed in an organic small molecule acid solution, so that the stent is obtained after reacting for a certain time. The titanium dioxide-citric acid coating is constructed according to the anti-coagulation requirement of the dense net stent, and the coating can enable the dense net stent to be continuously anti-coagulated in the in-vivo service period, so that the postoperative anti-coagulation treatment dosage of a patient is reduced, and the economic pressure and psychological burden of the patient are reduced.

Description

technical field [0001] The invention belongs to the technical field of medical device implants, and in particular relates to an anticoagulant dense mesh support and a preparation method thereof. Background technique [0002] An aneurysm, a swelling that results from a lesion or injury to the wall of an artery, is a common vascular disorder. If not treated in time, the aneurysm may rupture at any time, threatening the life and health of the patient. At present, there are three main treatment methods for aneurysms: traditional surgical clipping, coil embolization, and implantation of dense mesh stents or covered stents in the lesion. Surgical operations are difficult, traumatic and complicated, and are generally not chosen by patients and doctors. Coil embolization has high risk and poor effect in the treatment of large aneurysms, wide-mouth aneurysms, pseudoaneurysms, and recurrent aneurysms. The implantation of dense-mesh stents can guide the blood to flow along the norma...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/08A61L31/16A61L31/14A61L31/02A61L33/00A61L33/04A61F2/90
CPCA61L31/08A61L31/16A61L31/14A61L31/022A61L33/0041A61L33/04A61F2/90A61L2300/42A61L2300/606A61L2300/21A61L2300/23A61L2400/12
Inventor 徐兰馨
Owner 成都百瑞恒通医疗科技有限公司
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