Blend polyvinylidene fluoride hollow fiber film and making method thereof

A polyvinylidene fluoride, fiber membrane technology, applied in chemical instruments and methods, membrane technology, semi-permeable membrane separation, etc., can solve the problems of poor effect, incompatibility and anticoagulation, etc. Anti-pollution, easy to realize industrialization, good biocompatibility

Active Publication Date: 2016-04-27
TIANJIN POLYTECHNIC UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] Aiming at the problem that the existing PVDF hollow fiber membrane is incompatible with blood and has poor anticoagulant effect, the present invention provides a blended polyvinylidene fluoride hollow fiber membrane for hemodialysis and its preparation The method, the membrane preparation method is simple, suitable for industrial production, the obtained hollow fiber membrane has the characteristics of high strength and high flux, and has a good removal effect on toxic substances of medium and low molecular weight in blood, and can be used in the field of hemodialysis

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] (1) Preparation of polyvinylidene fluoride grafted polyacryloylmorpholine and argatroban copolymer:

[0027] Add PVDF powder with a ratio of 100g / L to 2.5mol / L sodium hydroxide solution, and add 10ml / L absolute ethanol to the above alkali solution, and stir and react in a constant temperature water bath at 60°C for 10 minutes. The resulting product was suction filtered, and the PVDF powdery solid product obtained after washing was placed in an oven at 60° C. for drying.

[0028]Add 16g of alkali-treated PVDF powder into a three-necked flask containing 120g of DMF to prepare a homogeneous solution, then add 0.2g of AIBN, then add ACMO monomer and AA monomer with a molar ratio of 1:1:2 to PVDF, Under the protection of a nitrogen atmosphere, react at 70°C for 12 hours. The solution after the reaction is precipitated in excess methanol and filtered by suction. Vinyl fluoride grafted polyacryloylmorpholine and acrylic acid copolymer; Then, the multipolymer of 5g gained and ...

Embodiment 2

[0035] (1) Preparation of polyvinylidene fluoride grafted polyacryloylmorpholine and argatroban copolymer:

[0036] Add PVDF powder with a ratio of 180g / L to 10mol / L sodium hydroxide solution, and add 30ml / L absolute ethanol to the above alkali solution, stir and react in a constant temperature water bath at 60°C for 10 minutes. The resulting product was suction filtered, and the PVDF powdery solid product obtained after washing was placed in an oven at 60° C. for drying.

[0037] Add 16g of alkali-treated PVDF powder into a three-necked flask containing 80g of DMSO to prepare a homogeneous solution, then add 1.6g of AIBN, and then add ACMO monomer and AA monomer with a molar ratio of 1:1:4 to PVDF, Under the protection of a nitrogen atmosphere, react at 70°C for 12 hours. The solution after the reaction is precipitated in excess methanol and filtered by suction. Vinyl fluoride grafted polyacryloyl morpholine and acrylic acid copolymer; then, 5g of the resulting copolymer and...

Embodiment 3

[0044] (1) Preparation of polyvinylidene fluoride grafted polyacryloylmorpholine and argatroban copolymer:

[0045] Add PVDF powder with a ratio of 180g / L to 5mol / L sodium hydroxide solution, and add 10ml / L absolute ethanol to the above alkali solution, stir and react in a constant temperature water bath at 60°C for 10 minutes. The resulting product was suction filtered, and the PVDF powdery solid product obtained after washing was placed in an oven at 60° C. for drying.

[0046] Add 16g of alkali-treated PVDF powder into a three-necked flask containing 240g of DMAC to prepare a homogeneous solution, then add 0.8g of AIBN, then add ACMO monomer and AA monomer with a molar ratio of 1:1:2 to PVDF, Under the protection of a nitrogen atmosphere, react at 70°C for 12 hours. The solution after the reaction is precipitated in excess methanol and filtered by suction. Vinyl fluoride grafted polyacryloylmorpholine and acrylic acid copolymer; Then, the multipolymer of 5g gained and 1g a...

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Abstract

The invention belongs to the field of hollow fiber films, and especially relates to a blend polyvinylidene fluoride hollow fiber film used for hemodialysis, and a making method thereof. The method concretely comprises the following steps: blending dried polyvinylidene fluoride, polyvinylidene fluoride grafted polypropylene morpholide and argatroban copolymer, a pore forming agent and a cosolvent to prepare a film casting liquid; carrying out air bath on nascent hollow fibers formed after extruding the film casting liquid through a spinning head, allowing the obtained hollow fibers to enter a coagulation bath, coagulating and regenerating the hollow fibers, and reeling the hollow fibers to obtain a hollow fiber film; and immersing and cleaning the obtained hollow fiber film in pure water, taking out the cleaned hollow fiber film, and immersing the obtained hollow fiber film in a solution containing a pore keeping agent to obtain the finished blend modified polyvinylidene fluoride hollow fiber film. Blending is carried out to realize the hydrophilic modification purpose in order to finally improve the pollution resistance, the blood compatibility and the anticoagulant performance of the film. The hollow fiber film obtained in the invention has the advantages of high strength, high flux, good removal effect of toxic substances with a low molecular weight in blood, and wide application prospect.

Description

Technical field: [0001] The invention belongs to the field of blended polyvinylidene fluoride hollow fiber membranes, in particular to the preparation of blended polyvinylidene fluoride hollow fiber membranes for hemodialysis. Background technique: [0002] In recent years, with the increase in the number of patients with end-stage renal disease, blood purification technology has become the main means of renal treatment and one of the most widely used methods. With the popularization and development of blood purification technology, the survival period of uremia patients has been significantly prolonged and the quality of life has been significantly improved, but many long-term complications have also appeared, such as renal bone disease, dialysis-related amyloidosis, cardiovascular disease etc. At present, the hollow fiber membrane material used in hemodialysis is regarded as a foreign body in the body. When it comes into contact with blood, it will inevitably cause a seri...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D69/08B01D71/78B01D71/34B01D67/00B01D61/24
CPCB01D61/243B01D69/08B01D71/34B01D71/78
Inventor 陈莉安子韩赵义平冯倩倩薛高建
Owner TIANJIN POLYTECHNIC UNIV
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