Anticoagulation modification method for hemodialyzer and application thereof

A technology of hemodialysis and modification, applied in dialysis systems, blood circulation treatment, suction equipment, etc., can solve problems such as few reports, difficult removal of organic solvents, and hidden dangers of organic solvents for patients, and achieve simple process steps and post-processing The effect of simple processing and easy industrial production promotion

Active Publication Date: 2019-04-26
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, how to achieve stable loading of heparinoids on the inner surface of hemodialysis membranes, especially for anticoagulant modification of encapsulated hemodialyzers, is rarely reported.
Furthermore, in the existing reports of other modification technology systems based on organic solvents, the organic solvents are very difficult to remove in the subsequent cleaning process, and the residue of organic solvents poses a very large safety hazard to patients during the dialysis process.

Method used

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  • Anticoagulation modification method for hemodialyzer and application thereof
  • Anticoagulation modification method for hemodialyzer and application thereof
  • Anticoagulation modification method for hemodialyzer and application thereof

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preparation example Construction

[0037] Wherein, as a more preferred embodiment of the present invention, the synthesis method of the active heparin aqueous solution comprises the following steps:

[0038] (1) Add a certain amount of alkene acid monomers, sodium sulfonate monomers, and crosslinking agent monomers to 100 parts by mass of deionized water, and then stir for not less than 30 minutes in a nitrogen or argon atmosphere to remove the reaction solution. of oxygen;

[0039] (2) Add a certain amount of initiator, keep stirring in a nitrogen or argon atmosphere, and raise the temperature to 50-100° C., and react for 4-24 hours to obtain an aqueous solution of active heparin.

[0040] Further, in step (1), the alkenoic monomer includes but not limited to a mixture of one or more of acrylic acid, methacrylic acid, phenylacrylic acid, sorbic acid and the like.

[0041] Further, the sodium sulfonate monomer includes but is not limited to a mixture of one or more of sodium p-styrene sulfonate, sodium propyle...

Embodiment 1

[0064] Step (1) Add 200g of deionized water into a three-necked flask, then add 6g of acrylic acid, 8g of sodium p-styrenesulfonate and 10g of N-methylolacrylamide, and then stir for 40min under a nitrogen atmosphere at 250 rpm , to get rid of the oxygen in the reaction solution;

[0065] Step (2) Add 0.4 g of azobisisobutylamidine hydrochloride, keep stirring in a nitrogen atmosphere, and raise the temperature to 80° C., and react for 10 hours to obtain an aqueous solution of active heparin;

[0066] Step (3) inject the hemodialyzer product (encapsulation polysulfone membrane, i.e. the product in Comparative Example 1) bought in the market for 5 minutes, and then inject the active heparin aqueous solution synthesized in step (2) into the hemodialyzer , stay for 1.5h to make it completely wet the inner surface of the hemodialyzer membrane;

[0067] Step (4) Drain the active heparin-like aqueous solution from the hemodialyzer, then inject acidic deionized water with a pH value...

Embodiment 2

[0072] Step (1) Add 200g of deionized water to a three-necked flask, then add 2g of methacrylic acid, 2g of sodium propylene sulfonate and 2g of N-hydroxyethylacrylamide, and then stir at 200 rpm in an argon atmosphere 30min, to get rid of the argon in the reaction solution;

[0073] Step (2) Add 0.07 g of azobisisobutylimidazoline hydrochloride, keep stirring in an argon atmosphere, and raise the temperature to 100° C., and react for 4 hours to obtain an aqueous solution of active heparin;

[0074] Step (3) First inject the hemodialyzer product (encapsulated polyethersulfone membrane) purchased in the market into deionized rinse for 5 minutes, then inject the active heparin aqueous solution synthesized in step (2) into the dialyzer, and stay for 0.5h to make it completely Wetting the inner surface of the hemodialyzer membrane filament;

[0075] Step (4) Drain the active heparin-like aqueous solution from the hemodialyzer, then inject acidic deionized water with a pH value of...

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Abstract

The invention discloses an anticoagulation modification method for a hemodialyzer and an application thereof. The anticoagulation modification method for the hemodialyzer comprises the following steps: triggering polymerization cross-linking reaction of a uniform mixed reaction system of olefine acid monomer, sodium sulfonate monomer, cross-linking agent monomer, initiator and water under a protective atmosphere, thereby acquiring an active heparinoid aqueous solution; keeping the membrane silk inner surface of hemodialyzer in touch with the active heparinoid aqueous solution, and then separating; heating the hemodialyzer under an acidic condition and performing auto-agglutination cross-linking, thereby acquiring the hemodialyzer with high anticoagulation property. The hemodialyzer prepared according to the invention has excellent blood compatibility and high anticoagulation property; the anticoagulation modification technology is based on a water-base system in the whole process; during the whole modifying process, only the required heparinoid substances and water are introduced; the posttreatment, such as subsequent cleaning of membrane silk, is simple; the processing steps are simple, easy for operation and realization and easy for industrial production and popularization.

Description

technical field [0001] The invention belongs to the field of blood purification, and in particular relates to an anticoagulant modification method of a hemodialyzer and its application in blood purification. Background technique [0002] When acute or chronic renal insufficiency develops to a severe stage, due to the accumulation of metabolites and the disturbance of water, electrolyte, and acid-base balance, endocrine dysfunction will cause a series of autotoxic symptoms in the body, which is called uremia. Nitrogen-containing metabolites and other toxic substances cannot be excreted and accumulate in the body due to uremia, causing lesions in multiple organs and systems. For patients with renal failure, the source of kidney is a difficult problem in kidney transplantation, and it takes a lot of trouble to find a suitable kidney source. At this time, hemodialysis technology becomes the key to maintaining the life of patients with kidney disease. Hemodialysis is one of the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/36A61M1/16
CPCA61M1/16A61M1/3673
Inventor 刘富林海波韩秋柳杨王辉
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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