Anticoagulant modification method and application of a kind of hemodialyzer

A technology of hemodialysis and modification, applied in dialysis systems, blood circulation treatment, suction equipment, etc., can solve problems such as few reports, hidden dangers of organic solvent patient safety, difficult removal of organic solvents, etc., and achieve simple and easy process steps The effect of industrial production promotion and simple post-processing
CN109675134BActive Publication Date: 2021-06-08NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
Publication Date
2021-06-08

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Abstract

The invention discloses an anticoagulant modification method of a hemodialyzer and an application thereof. The anticoagulant modification method of the hemodialyzer comprises: in a protective atmosphere, polymerizing a uniformly mixed reaction system comprising an alkenoic acid monomer, a sodium sulfonate monomer, a crosslinking agent monomer, an initiator and water Cross-linking reaction to obtain an active heparin-like aqueous solution; contacting the inner surface of the membrane filament of the hemodialyzer with the active heparin-like aqueous solution, followed by separation; Obtain a hemodialyzer with high anticoagulant performance. The hemodialyzer prepared by the present invention has excellent hemocompatibility and high anticoagulant performance, and the anticoagulant modification technology is based on a water-based system throughout, and only necessary heparin-like substances and Water, subsequent cleaning of membrane filaments and other post-treatments are very simple; at the same time, the process steps are simple, easy to operate and realize, and easy to promote industrial production.
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Description

technical field

[0001] The invention belongs to the field of blood purification, and in particular relates to an anticoagulant modification method of a hemodialyzer and its application in blood purification. Background technique

[0002] When acute or chronic renal insufficiency develops to a severe stage, due to the accumulation of metabolites and the disturbance of water, electrolyte, and acid-base balance, endocrine dysfunction will cause a series of autotoxic symptoms in the body, which is called uremia. Nitrogen-containing metabolites and other toxic substances cannot be excreted and accumulate in the body due to uremia, causing lesions in multiple organs and systems. For patients with renal failure, the source of kidney is a difficult problem in kidney transplantation, and it takes a lot of trouble to find a suitable kidney source. At this time, hemodialysis technology becomes the key to maintaining the life of patients with kidney disease. Hemodialysis is one of the...

Claims

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