Anti-coagulation anti-bacterial biomedical material and preparation method thereof

Abstract

The invention relates to an anti-coagulation anti-bacterial biomedical material and a preparation method thereof in particular. The anti-coagulation anti-bacterial material is a composite material prepared by mixing a heparinized anti-coagulation material which is obtained by performing heparinization on an amidogen-containing natural biological material by a chemical covalent grafting method and an anti-bacterial material which takes chitosan as a substrate. The difunctional anti-coagulation anti-bacterial material of the invention has not only high blood compatibility, but also very good anti-staphylococcus aureus function. The novel material has double functions of anti-coagulation and antibacterium for the first time, and has a broad application prospect in clinical vascular repair.

Description

technical field

[0001] The invention belongs to the field of biomedical materials, and in particular relates to an anticoagulant and antibacterial biomedical material and a preparation method thereof. Background technique

[0002] With the development of population aging process, the number of patients with cardiovascular diseases in our country is increasing year by year, so the demand for artificial blood vessel materials and anticoagulant medical materials is increasing day by day. Whether it is used as a vascular replacement material or a stent material inside a blood vessel, its blood compatibility is a prerequisite for determining whether it has clinical application value. Therefore, improving and improving the blood compatibility of materials is one of the important research directions in the field of vascular repair materials. At present, there are many methods for preparing anticoagulant materials, such as heparin immobilization, increasing the water content of mat...

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