Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof

A polystyrene microsphere, high-resistance technology, used in the preparation of microspheres, microcapsule preparations, chemical instruments and methods, etc., can solve problems such as poor blood coagulation, achieve excellent blood compatibility, strong anticoagulation performance, Easy to operate and achieve effects

Active Publication Date: 2019-05-10
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, all kinds of polystyrene microsphere adsorbents currently in clinical use on the market or newly developed by researchers all have a common deficiency. They are prone to poor coagulation during use, which leads to anemia

Method used

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  • Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof
  • Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof
  • Highly anti-coagulant polystyrene microsphere and preparation and application methods thereof

Examples

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Example Embodiment

[0030] Another aspect of the embodiments of the present invention also provides a method for preparing highly anticoagulated polystyrene microspheres, which includes:

[0031] In a protective atmosphere, a uniformly mixed reaction system containing acrylic acid monomers, sodium sulfonate monomers, crosslinking agent monomers, initiators and water is polymerized and crosslinked at 50-100°C for 4-24 hours to obtain Active heparin aqueous solution;

[0032] The polystyrene microspheres are brought into contact with the active heparin aqueous solution, and then the obtained polystyrene microspheres are placed in acidic conditions and heated at 45-80°C for 6-24 hours to obtain high anticoagulation through self-polymerization and crosslinking Type polystyrene microspheres.

[0033] In some preferred embodiments, the preparation method specifically includes: adding olefinic acid monomers, sodium sulfonate monomers, and crosslinking agent monomers to deionized water, and then stirring in a ...

Example Embodiment

[0035] Among them, as a more preferred embodiment of the present invention, the preparation method includes the following steps:

[0036] S1: Add a certain amount of olefinic acid monomers, sodium sulfonate monomers, and crosslinking agent monomers to 100 parts by mass of deionized water, and then stir under nitrogen or argon atmosphere for no less than 30 minutes to eliminate the reaction liquid oxygen;

[0037] S2: Add a quantitative initiator, keep stirring under nitrogen or argon atmosphere, and raise the temperature to 50-100°C, and react for 4-24 hours to obtain an active heparin aqueous solution;

[0038] S3: After the obtained active heparin aqueous solution is cooled to room temperature, add quantitative polystyrene microspheres to the solution and soak for 0.15-2h;

[0039] S4: Transfer the polystyrene microspheres to an acidic aqueous solution with a pH of 0-4, heat at 45-80°C for 6-24 hours, and then clean with deionization and dry to obtain the high anti-coagulation poly ...

Example Embodiment

[0060] Example 1

[0061] Step (1) Add 100g of deionized water into a three-necked flask, then add 3g of acrylic acid, 4g of sodium p-styrene sulfonate and 5g of N-methylolacrylamide, and then stir for 40min under a nitrogen atmosphere at 250 rpm To eliminate oxygen in the reaction liquid;

[0062] Step (2) Add 0.2g of azobisisobutamidine hydrochloride, keep stirring under nitrogen atmosphere, and raise the temperature to 80°C, and react for 10 hours to obtain an active heparinoid aqueous solution;

[0063] Step (3) Weigh 20 g of polystyrene microspheres (commercially available product as described in Comparative Example 1), and first ultrasonically clean with 20% ethanol / deionized solution for 20 minutes. Then, after the heparin-like aqueous solution obtained in step (2) is cooled to room temperature, the washed polystyrene microspheres are added to the solution and soaked for 1 hour;

[0064] Step (4) Transfer the polystyrene microspheres to an acidic aqueous solution with a pH val...

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Abstract

The invention discloses a highly anti-coagulant polystyrene microsphere and preparation and application methods thereof. The highly anti-coagulant polystyrene microsphere comprises a polystyrene microsphere body and an anti-coagulant modification layer formed on the surface of the polystyrene microsphere body, wherein the anti-coagulant modification layer comprises a heparinoid functional layer, and the heparinoid function layer comprises an active heparinoid polymer prepared by polymerizing and crosslinking olefin acid monomers, sodium sulfonate monomers and crosslinking agent monomers. The preparation method of the highly anti-coagulant polystyrene microsphere comprises subjecting the olefin acid monomers, the sodium sulfonate monomers, the crosslinking agent monomers and initiators to polymerization and crosslinking reaction to obtain an active heparinoid aqueous solution, subjecting the polystyrene microsphere body to contact with the active heparinoid aqueous solution and then auto-polymerization and crosslinking under acid conditions to obtain the highly anti-coagulant polystyrene microsphere. The prepared highly anti-coagulant polystyrene microsphere is high in blood compatibility, and meanwhile, the preparation method of the highly anti-coagulant polystyrene microsphere is simple in technical process, easy to operate and implement and applicable to industrial productionand popularization.

Description

technical field [0001] The invention belongs to the field of blood purification, and in particular relates to an anticoagulation modification method of a blood toxin adsorbent, in particular to a high anticoagulation polystyrene microsphere, a preparation method thereof, and an application thereof in blood purification. Background technique [0002] Blood purification is currently the core treatment method for patients with kidney disease (especially uremia) to maintain life, and it is also one of the important treatment methods in the fields of poisoning first aid, liver disease and critical illness. At present, the means of blood purification are mainly membrane separation and adsorption separation. Among them, membrane separation can efficiently remove small-molecule toxins in blood, but its ability to remove middle-molecule microglobulins (such as β-microglobulin), pathogenic factors, and interleukins in blood is very limited. Adsorption separation technology must be us...

Claims

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Application Information

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IPC IPC(8): C08F220/58C08F212/14C08F220/06C08F228/02C08J7/12B01J13/14A61M1/16A61M1/36C08L33/24C08L5/08B01J20/26B01J20/28B01J20/30
Inventor 林海波刘富韩秋柳杨
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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